[1]李林,史剑慧.神经酰胺与辐射诱导细胞凋亡[J].国际放射医学核医学杂志,2000,24(2):85-89.
 LI Lin,SHI Jian-hui.Ceramide and apoptosis induced by radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(2):85-89.
点击复制

神经酰胺与辐射诱导细胞凋亡(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
24
期数:
2000年第2期
页码:
85-89
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Ceramide and apoptosis induced by radiation
作者:
李林 史剑慧
200032 上海, 上海医科大学放射医学研究所
Author(s):
LI Lin SHI Jian-hui
Institute of Radiation Medicine, Shanghai Medical University, Shanghai 200032, China
关键词:
神经酰胺细胞凋亡辐射敏感性
Keywords:
ceramidecellular apoptosisradiation sensitivity
分类号:
Q506
摘要:
神经酰胺作为神经鞘脂类的主要成员之一,是一个主要调节细胞活动的第二信使,以转导细胞凋亡等细胞生长抑制活动信号为主。研究表明,神经酰胺通路不同水平的功能性变化直接影响细胞的药敏感性和辐射敏感性,肿瘤细胞神经酰胺缺陷可导致肿瘤细胞对药物和电射的敏感性下降。
Abstract:
Ceramide as an important member of sphingolipid is a second messenger responsible for regulating cellular activities, whose major function is to transmit growth-inhibiting signals including apoptotic.It has been proven by a lot of experimental facts that the changes of the functions at different levels of ceramide signaling pathway directly affect cellular drug sensitivity and radiation sensitivity.In addition, the defective functions of ceramide signaling path in tumor cells may result in the decrease of their drug sensitivity and radiation sensitivity.

参考文献/References:

[1] Spiegel S, Foster D, Kolesnick R. Signal transduction through lipid second messengers[J]. Curr Opin Cell Biol,1996, 8(2):159~167.
[2] Merrill AH Jr, Schmelz EM,Dillehay DL, et al. Sphingolipids- the enigmatic lipid class:biochemistry, physiology, and pathophysilogy[J]. Toxicol Appl Pharmacol,1997, 142(1):208~225.
[3] Tepper AD,Cock JG,de Vries E,et al.CD 95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibition[J]. J Biol Chem,1997, 272(39):24308~24312.
[4] Boland MP, Foster SJ, O’Neill LA. Daunorubicin activates N FkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cell[J]. J Biol Chem,1997, 272(20):12952~12960.
[5] Verheij M,Bose R, Lin XH, et al. Requirement for ceramide-initiated SAPK/JNK signaling in stress-induced apoptosis[J]. Nature, 1996, 380(6569):75~79.
[6] Michael JM, Lavin MF, Watters DJ. Resistance to radiation-induced apoptosis in Burkitt’s lymphoma cell is associated with defective ceramide signaling[J]. Canaer Res,1997, 57(16):3600~3605.
[7] Kimura K,Bowen C,Spiegal S,et al.Tumor necrosis factor-α sensitizes prostate cancer cells to γ-irradiation-induced apoptosis[J]. Canaer Res, 1999, 59:1606~1614.
[8] Vidair CA Chen CH,ing CC,et al.Apoptosis induced by X-irradiation of rec-myc cell is postmitotic not predicted by the time after irradiation or behavior of sister cells[J]. Cancer Res, 1996, 56:4116~4118.
[9] Chmura SJ,Mauceri HJ,Advani S,et al.Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation incrases tumor killing by ionizing radiation[J]. Cancer Res, 1997, 57(19):4340~4347.
[10] Bruno AP,Laurent G,Averbeck D,et al.Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation[J]. Cell Death Differ, 1998, 5(2):172~182.
[11] Chmura SJ, Nodzenski E, Weichselbaum RR, et al. Protrin kinase C inhibition induces apoptosis and ceramide production through activation of a neutral sphingomyelinase[J]. Cancer Res, 1996, 56(12):2711~2714.
[12] Chmura SJ,Nodzenski E,Crane MA,et al.Cross-talk between ceramide and PKC activity in the control of apoptosis in W EHI-231[J]. Adv Exp Med Biol, 1996, 406:39~55.
[13] Haimovtz-Friedman A. Radiation-induced signal transduction and stress response[J]. Radiat Res,1998, 150(5 Suppl):S102~S108.
[14] Nyberg L, Duan RD, Axelson J, et al. Identification of an alkaline sphingomyelnase activity in human bile[J]. Biochim Biophys Acta, 1996, 1300(1):42~48.
[15] Chmura SJ,Nodzenski E,Beckett MA et al.Loss of ceramide production confers resistance to radiaion-induced apoptosis[J]. Cancer Res, 1997, 57(7):1270~1275.
[16] Santana P,Pena LA,Haimovitz-Friedman A,et al.Acid sphingomyelinase-deficient human lympoblasts and mice are defective in radiation-induced apoptosis[J]. 1996, 86(2):189~199.
[17] Burrow M E, Weldon CB, Tangy, et al. Differences in susceptibility to tumor necrosis factr-α-induced apoptosis among MCF-7 breast cancer cell variants[J]. Cancer Res, 1998, 58:4940~4946.
[18] Cai Z, Bettaieb A, Mahdani N ET, et al. Alteration of the sphingomyelin/ceramide pathway is associated with resistance of human breast carcinoma MCF7 cells to tumor necrosis factor-α-mediated cytotoxicity[J]. J Biol Chem, 1997, 272:6918~6926.

相似文献/References:

[1]陈顺军,程兵.肿瘤细胞凋亡核素显像分子探针研究进展[J].国际放射医学核医学杂志,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
 Chen Shunjun,Cheng Bing.Progress in molecular probes of radionuclide tumor apoptosis imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
[2]张俊伶,薛晓蕾,李源,等.富氢水对电离辐射引起胸腺细胞损伤的影响[J].国际放射医学核医学杂志,2015,39(5):358.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 001]
 zhang junling,xue xiaolei,li yuan,et al.effects of hydrogen-rich water on radiation-induced thymus injury[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):358.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 001]
[3]安淑娴,宋少莉,黄钢.放射性核素标记的凋亡显像剂的研究进展[J].国际放射医学核医学杂志,2015,39(6):470.[doi:10.3760/cma.j.issn.1673-4114.2015.06.008]
 An Shuxian,Song Shaoli,Huang Gang.Recent advances in apoptosis imaging using radionuclide-labeled tracers[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):470.[doi:10.3760/cma.j.issn.1673-4114.2015.06.008]
[4]徐畅,王彦,杜利清,等.shRNA干扰沉默Net1基因对电离辐射损伤反应的影响[J].国际放射医学核医学杂志,2013,37(3):135.[doi:10.3760/cma.j.issn.1673-4114.2013.03.002]
 XU Chang,WANG Yan,DU Li-qing,et al.The effects of short hairpin RNA-mediated silencing Net1 on ionizing radiation-induced damage responses[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(2):135.[doi:10.3760/cma.j.issn.1673-4114.2013.03.002]
[5]郭艳婷,张鹏飞,刘强.Smac与肿瘤放射治疗[J].国际放射医学核医学杂志,2013,37(5):309.[doi:10.3760/cma.j.issn.1673-4114.2013.05.014]
 GUO Yan-ting,ZHANG Peng-fei,LIU Qiang.Effects of Smac on tumor radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(2):309.[doi:10.3760/cma.j.issn.1673-4114.2013.05.014]
[6]邓惠兴,马爱群.核医学影像技术在心肌炎诊断中的应用[J].国际放射医学核医学杂志,2009,33(1):39.[doi:10.3760/cma.j.issn.1673-4114.2009.01.039]
 DENG Hui-xing,MA Ai-qun.The application of radionuclide imaging technology in myocarditis[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(2):39.[doi:10.3760/cma.j.issn.1673-4114.2009.01.039]
[7]尹培,边艳珠.体内凋亡细胞显像的研究进展[J].国际放射医学核医学杂志,2009,33(5):279.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.007]
 YIN Pei,BIAN Yan-zhu.Development of apoptosis imaging in vivo[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(2):279.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.007]
[8]张颖,林军.125I粒子治疗对肝癌细胞凋亡及细胞周期的影响[J].国际放射医学核医学杂志,2009,33(4):193.[doi:10.3760/cma.j.issn.1673-4114.2009.04.001]
 ZHANG Ying,LIN Jun.Effects of 125I seed brachytherapy on apoptosis and cell cycle distribution in hepatoma carcinoma cells[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(2):193.[doi:10.3760/cma.j.issn.1673-4114.2009.04.001]
[9]杨岩,王娟,王冠军.低剂量辐射对人骨髓间充质干细胞影响的研究[J].国际放射医学核医学杂志,2008,32(3):183.
 YANG Yan,WANG Juan,WANG Guan-jun.Study on human mesenchymal stem cells from bone marrow pretreated with low dose radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(2):183.
[10]张敬勉,赵新明,王建方,等.99Tc-亚甲基二膦酸盐与153Sm-乙二胺四亚甲基膦酸对骨侵袭和骨质溶解抑制作用的对比研究[J].国际放射医学核医学杂志,2008,32(6):321.
 ZHANG Jing-mian,ZHAO Xin-ming,WANG Jian-fang,et al.The comparative study of inhibitory effects of 99Tc-methylenediphosphonate and 153Sm-ethylene diamine tetramethylene phosphonic acid on bone invasion and osteolysis[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(2):321.

备注/Memo

备注/Memo:
收稿日期:1999-08-10。
作者简介:李林(1974-),女,福建福州人,上海医科大学放射医学研究所第三研究室硕士研究生,主要从事实验血液及实验肿瘤研究;史剑慧(1961-),女,浙江平湖人,上海医科大学放射学研究所第三研究室副研究员,博士研究生,主要从事实验血液及实验肿瘤研究。
更新日期/Last Update: 1900-01-01