[1]谭业颖.18F-氟脱氧胸苷PET的肿瘤分子显像研究进展[J].国际放射医学核医学杂志,2007,31(1):6-8,20.
 TAN Ye-ying.Advances in tumor molecular imaging with 18F-fluorothymidine PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(1):6-8,20.
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18F-氟脱氧胸苷PET的肿瘤分子显像研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第1期
页码:
6-8,20
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Advances in tumor molecular imaging with 18F-fluorothymidine PET
作者:
谭业颖
100853 北京, 解放军总医院核医学科
Author(s):
TAN Ye-ying
Department of Nuclear Medicine, The PLA General Hospital, Beijing 100853, China
关键词:
体层摄影术发射型计算机18F-氟脱氧胸苷细胞增殖氟脱氧葡萄糖F18对比研究
Keywords:
Tomography emvssion computedProliferation18F-fluorothymidine18F-fluorod-eoxyglucoseComparative study
分类号:
R817.4
摘要:
近年来,细胞增殖显像剂18F-氟脱氧胸苷(18F-FLT)受到重视。18F-FLTPET细胞增殖显像为肿瘤的诊断、分期、预后和疗效观察提供了非创伤性的手段,与18F-氟脱氧葡萄糖(18F-FDG)比较表明,18F-FLT与肿瘤细胞增殖的相关性明显高于18F-FDG,但敏感性低,而且不能反映所有类型的肿瘤细胞增殖情况。
Abstract:
In recent years, 18F-fluoro-3’-deoxy-3’-L-fluorothymidine (18F-FLT) has been developed as a proliferation tracer, hnaging and measurement of proliferation with PET could provide us with a non-invasive tool to value tumor cell proliferation rate and to monitor the response to anticancer treatment. In this review, the basis of 18F-FLT as a proliferation tracer is discussed. Furthermore, an overview of the current status of 18F-FLT PET research is given. The results of research show that 18F-FLT PET can correctly reflect cellular proliferation, it also has certain limitations. In comparisonwith 18F-FDG, 18F-FLT uptake is lower in most cases. Furthermore, 18F-FLT uptake does not reflect all kinds of cell proliferation.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2006-07-19。
更新日期/Last Update: 1900-01-01