[1]彭添兴,吴华.18F-氟脱氧葡萄糖以外新型PET肿瘤显像剂[J].国际放射医学核医学杂志,2007,31(1):9-12.
　PENG Tian-xing,WU Hua.New type PET imaging agent excluding 18F-fluorodeoxyglucose in oncology[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(1):9-12.
点击复制

18F-氟脱氧葡萄糖以外新型PET肿瘤显像剂(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第1期
页码:
9-12
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
New type PET imaging agent excluding 18F-fluorodeoxyglucose in oncology
作者:
彭添兴;  吴华
361003 厦门, 福建医科大学附属厦门第一医院核医学科、闽南PET中心
Author(s):
PENG Tian-xing;  WU Hua
Department of Nuclear Medicine and Minnan PET Center, Xiamen First Hospital of Fujian Medical University, Xiamen 361003, China
关键词:
放射性药物; 肿瘤学; 体层摄影术; 发射型计算机
Keywords:
Radiopharmaceuticals; Oncology; Tomography;  emission computed
分类号:
R817.4
摘要:
18F-氟脱氧葡萄糖PET虽是一种非常敏感的技术,但其特异性不高,有一定的局限性。因此,其他一些用于研究氨基酸摄取、蛋白质合成、DNA合成、细胞增殖、三羧酸循环中其他底物的代谢改变、肿瘤乏氧性、免疫活性和受体的示踪剂有望成为新的肿瘤显像剂。这些药物主要包括,18F、11C等标记的用于PET肿瘤显像的短半衰期放射性药物。
Abstract:
18F-fluorodeoxyglucose PET is a very sensitive technology, yet it still has limitation such as low specificity. In this way, tracers used to study amino acid uptake, protein synthesis, DNA synthesis, cell proliferation, changes of other substrates of tricarboxylic aciol cycle metabolism, tumor hypoxia, immunological activity and receptor are expected to be new tumor imaging agent, The study and possible use of short half-life radiopharmaceuticals(excluding FDG) in oncology with positron emission tomography are reviewed in this article, those that include 18F and 11C labeled compounds.

参考文献/References:

1 Tang G, Wang M, Tang X, et al. Fully automated synthesis module for preparation of S-(2-[18F] fluoroethyl)-L-methionine by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin. Nucl Med Biol, 2003, 30(5):509-512.
2 Tang GH, Tang XL, Wang MF, et al. Automated commercial synthesis system for preparation of O-(2-[18F]fluoroethyl)-L-tyrosine by direct nucleophilic displacement on a resin column. J Labelled Compd Radiopharm, 2003, 46(7):661-668.
3 Tang G, Tang X, Wang M, et al. Fully automated synthesis of O-(3-[18F]fluoropropyl)-L-tyrosine by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin. Appl Radiat Isot, 2003,58(6):685-689.
4 张宏,田梅.PET在骨和软组织肿瘤方面的应用.实用肿瘤杂志,2005,20(2):98-101.
5 朴日阳,崔瑞雪,杜宜奎,等.O-(2-18F-氟代乙基)-L-酪氨酸的合成及初步动物实验.中华核医学杂志,2000,20(6):272-273.
6 吴春英,林祥通,张满达,等.18F标记的正电子放射性药物及其临床应用.中华核医学杂志,2002,22(2):125-128.
7 Hara T. 18F-Fluorocholine:a new oncologic PET tracer. J Nucl Med, 2001, 42(12):1815-1817.
8 吴战宏,王世真,周前,等.18F标记氟乙基胆碱的合成与动物显像.中华核医学杂志,2005,25(3):138-140.
9 Been LB, Suurmeijer AJ, Cobben DC, et al.18F-FLT PET in oncology:current status and opportunities, Eur J Nuel Med Mol Imaging,2004, 31(12):1659-1672.
10 Perault C, Schvartz C, Wampach H, et al. Thoracic and abdominal SPECT-CT image fusion without external markers in endocrine carcinomas. J Nucl Med, 1997, 38(8):1234-1242.
11 Alauddin MM, Shahinan A, Gordon EM, et al. Preclinical evaluation of the penciclovir analog 9-(4-[18F[fluoro-3-hy droxymethylbutyl) guanine for in vivo measurement of suicide gene expression with PET. J Nucl Med, 2001, 42(11):1682-1690.
12 唐刚华,张岚,唐小兰,等.6-氟-L-多巴的不对称合成.中国药科大学学报,2001,32(3):166-171.
13 Aliaga A, Rousseau JA, Ouellette R, et al. Breast cancer models to study the expression of estrogen receptors with small animal PET imaging. Nuel Med Biol, 2004, 31(6):761-770.
14 Mortimer JE, Dehdashti F, Siegel BA, et al. Metabolic flare:indicator of hormone responsiveness in advanced breast cancer. J Clin Oncol, 2001, 19(11):2797-2803.
15 Waterhouse RN, Fawwaz R, Atuahene NF, et al. Micro PET ima-ging and biodistri bution studies of the sigma-1 receptorradiot-racer 18F-FPS in the MMTV transgenic mouse breast cancer model. J Labelled Comp Radiopharm, 2003, 46(1):7.
16 Sorger D, Patta M, Kumard P, et al. 18F-fluoroazomycinarabino-furanoside (18F-FAZA) and 18F-fluoromisonidazole (18F-FMISO):a comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors. Nucl Med Biol, 2003, 30(3):317-326.
17 Zijlstra S, Gunawan J, Burchert W. Synthesis and evaluntion of a 18F labeled recombinant annexin-V derivative, for indentifieation and quantification of apoptotie cells with PET. Appl Radiat Isot,2003, 58(2):201-207.
18 Berride MS, Cassidy EH, Mirald F.[11C]aeetate and [11C]Meth-ionine:Improved synthesis and quality control. Appl Radiat lsot,1995, 46(3):173-175.
19 杨晓诚,胡怀湘,霍力.放射性标记氨基酸的肿瘤基础研究.国外医学·放射医学核医学分册,2003,27(1):25-27.
20 唐刚华.肿瘤氨基酸代谢正电子发射断层显像.第一军医大学学报,2002,22(12增刊):74-77.
21 Zhang H, Tian M, Oriuchi N, et al. 11C-choline PET for the detection of bone and soft tissue tumours in comparison with FDG PET. Nucl Med Commun, 2003, 24(3):273-279.
22 Price P, Harte R, Wells P, et al. The potential of tracer kinetic studies in drug development programs:a new investigation area for cancer research. Drug Inf J, 1997, 31(3):1045-1049.
23 Kaasinen V, Ruottinen HM, Nagren K, et al. Upregulation of putaminal dopamine D2 receptors in early Parkonson’s disease:a comparative PET study with 11C-raclopride and 11C-N-methyl-spierone. J Nucl Med, 2000, 41(1):65-70.
24 周克,杨勤,向燕.正电子放射性药物的现状与进展.西南军医,2005,7(2):47-48.
25 Johnstrom P, Fredriksson A, Thorell JO, et al. Synthesis of [Methoxy-11C] PD 153035, a selective EGF Receptor Tyrosine Kinase Inhibitor. 1998, 41(7):623-629.

相似文献/References:

[1]李海峰,张晓军,张锦明.多巴胺转运蛋白显像剂11C-β-CFT在帕金森病中的应用研究[J].国际放射医学核医学杂志,2016,40(3):218.[doi:10.3760/cma.j.issn.1673-4114.2016.03.011]
　Li Haifeng,Zhang Xiaojun,Zhang Jinming.Review of the use of dopamine transporter imaging agent 11C-β-CFT for diagnosing Parkinson disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):218.[doi:10.3760/cma.j.issn.1673-4114.2016.03.011]
[2]甘红梅,乔晋萍,孔爱英,等.正电子放射性显像剂代谢及其研究方法进展[J].国际放射医学核医学杂志,2010,34(2):65.[doi:10.3760/cma.j.issn.1673-4114.2010.02.001]
　GAN Hong-mei,QIAO Jin-ping,KONG Ai-ying,et al.The progress on researching method and metabolism of positron radiopharmaceutical[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(1):65.[doi:10.3760/cma.j.issn.1673-4114.2010.02.001]
[3]顾涛颖,石洪成.放射性药物治疗肿瘤骨转移性骨痛的作用[J].国际放射医学核医学杂志,2010,34(2):88.[doi:10.3760/cma.j.issn.1673-4114.2010.02.006]
　GU Tao-ying,SHI Hong-cheng.The use of radiopharmaceuticals for metastatic bone pain in cancer patients[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(1):88.[doi:10.3760/cma.j.issn.1673-4114.2010.02.006]
[4]周雪,乔晋萍,孔爱英,等.受体结合实验及其在放射性显像剂研究中的应用进展[J].国际放射医学核医学杂志,2010,34(6):321.[doi:10.3760/cma.j.issn.1673-4114,2010.06.001]
　ZHOU Xue,QIAO Jin-ping,KONG Ai-ying,et al.Progress on the application of ligand receptor binding assays in radiopharmaceuticals[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(1):321.[doi:10.3760/cma.j.issn.1673-4114,2010.06.001]
[5]耿建华,陈英茂.正电子图像的定量分析在临床肿瘤学中的应用[J].国际放射医学核医学杂志,2005,29(1):6.
　GENG Jian-hua,CHEN Ying-mao.Clinical applications of quantitative parameters of positron images in oncology[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(1):6.
[6]范我.用于肿瘤治疗的放射性药物[J].国际放射医学核医学杂志,2004,28(1):21.
　FAN Wo.Radiopharmaceuticals for tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(1):21.
[7]陈璟,吴华.核素炎症显像的研究进展[J].国际放射医学核医学杂志,2003,27(3):107.
　CHEN Jing,WU Hua.The development of radionuclide imaging of infection and inflammation[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(1):107.
[8]杨建权,李晔,张现忠.基于小分子肽的放射性药物[J].国际放射医学核医学杂志,2003,27(4):157.
　YANG Jian-quan,LI Ye,ZHANG Xian-zhnng.Peptide as carrier for diagnosis and treatment[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(1):157.
[9]赵军.PET/CT:当前研究和应用新进展[J].国际放射医学核医学杂志,2003,27(5):193.
　ZHAO Jun.Advances of research and clinical study on PET/CT[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(1):193.
[10]谷晓云.核医学诊断操作中的亚细胞水平吸收剂量及其生物效应[J].国际放射医学核医学杂志,2001,25(4):165.
　GU Xiao-yun.Cellular dosimetry and biological conseuences caused by diagnostic nuclear medicine[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(1):165.

备注/Memo

备注/Memo:
收稿日期:2006-02-02。
通讯作者:吴华,E-mail:wuhuaa@hotmail.com
更新日期/Last Update: 1900-01-01