[1]王峰,王自正.细胞凋亡显像的研究现状及发展前景[J].国际放射医学核医学杂志,2007,31(1):1-5.
　WANG Feng,WANG Zi-zheng.Apoptosis imaging: current state of the art and future perspective[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(1):1-5.
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细胞凋亡显像的研究现状及发展前景(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第1期
页码:
1-5
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Apoptosis imaging: current state of the art and future perspective
作者:
王峰;  王自正
210006 南京, 南京医科大学附属南京第一医院核医学科
Author(s):
WANG Feng;  WANG Zi-zheng
Department of Nuclear Medcine, Nanjing First Hospital affiliated, Nanjing Medical University, Nanjing 210006, China
关键词:
细胞凋亡; 钙磷脂结合蛋白V; 放射性核素显像; 磁共振成像; 荧光; 超声检查
Keywords:
Apoptosis; Radionuclide imaging; Annexin V; Magnetic resonance imaging; Flurescence; Ultrasonography
分类号:
R817.4
摘要:
对不同放射性核素、不同螯合剂和配体合成凋亡显像剂annexinV的标记、合成、各自的生物学特性作了全面的评价,并对实验结果和临床应用作了总结和分析,体外试验及体内显像表明,放射性核素标记annexinV及其衍生物能较灵敏地探测凋亡事件,细胞凋亡在心肌梗死、动脉粥样硬化及肿瘤形成等病理过程中发挥重要作用。凋亡显像能较好地评价心肌缺血再灌注损伤诱发的心肌凋亡,可早期评价和预测肿瘤放疗、化疗疗效,有助于指导建立个体化治疗方案。同时,对磁共振、超声、近红外线显像探测细胞凋亡作了分析,比较了不同影像学检查在探测细胞凋亡的优势和不足。
Abstract:
This review provides a critical and thorough overview of the radionpharmaceutical development and in vivo evaluation of all apoptosis-detecting radioligands that emerged so far, along with these possible applications in nuclear medcine. Radiolabelled annexin bears the promise of becoming a clinically applied radio-pharmaceutical with potential applications in cardiology and oncology. Visualization of cell death is important in pathologies such as myocardial infarction, atherosclerosis, and cancer. Furthermore, radiolabelled annexin may be developed as a tool for monitoring cell death-induceing or cell death-preventing therapies. Some futue perspective are presented with the aim of promoting the development of potential new strategies in pursuit of the idealcell death-detecting radioligand.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2006-04-29。
通讯作者:王峰,E-mail:fengwangch@hotmail.com
更新日期/Last Update: 1900-01-01