[1]陈铨,张永学.分子成像技术的研究进展[J].国际放射医学核医学杂志,2011,35(5):290-295.[doi:10.3760/cma.j.issn.1673-4114.2011.05.010]
 CHEN Quan,ZHANG Yong-xue.Progress on molecular imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(5):290-295.[doi:10.3760/cma.j.issn.1673-4114.2011.05.010]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
35
期数:
2011年第5期
页码:
290-295
栏目:
核医学技术与方法
出版日期:
1900-01-01

文章信息/Info

Title:
Progress on molecular imaging
作者:
陈铨 张永学
华中科技大学同济医学院附属协和医院核医学科, 湖北省分子影像重点实验室, 武汉 430022
Author(s):
CHEN Quan ZHANG Yong-xue
Department of Nuclear Medicine, Union Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Molecular Imaging Key Laboratory of Hubei Province of Wuhan 430022, China
关键词:
分子探针核医学显像磁共振成像超声检查光学成像
Keywords:
Molecular probeNuclear medicine imagingMagnetic resonance imagingUltrasonographyOptical imaging
DOI:
10.3760/cma.j.issn.1673-4114.2011.05.010
摘要:
分子成像是新时代的医学成像,它可以无创性监测活体内的细胞和分子水平的生物学过程,其中包括核医学分子显像、磁共振分子成像、超声分子成像、光学分子成像和X射线分子成像等。目前,由于多学科融合的发展,多模式融合成像技术已成功用于临床,如PET-CT和PET-MRI。随着分子探针的发展和多模式融合成像技术的成熟,越来越多的分子成像技术将会运用于临床诊断和治疗。
Abstract:
Molecular imaging is a new era of medical imaging, which can non-invasively monitor biological processes at the cellular and molecular level in vivo, including molecular imaging of nuclear medicine, magnetic resonance molecular imaging, ultrasound molecular imaging, optical molecular imaging and molecular imaging with X-ray. Recently, with the development of multi-subjects amalgamation, multi-modal molecular imaging technology has been applied in clinical imaging, such as PET-CT and PET-MRI. We believe that with development of molecular probe and multi-modal imaging, more and more molecular imaging techniques will be applied in clinical diagnosis and treatment.

参考文献/References:

[1] Weissleder R.Molecular imaging:exploring the next frontier.Radiology,1999,212(3):609-614.
[2] Weissleder R,Mahmood U.Molecular imaging.Radiology,2001,219(2):316-333.
[3] Blasberg RG,Tjuvajev JG.Molecular-genetic imaging:current and future perspectives.J Clin Invest,2003,111(11):1620-1629.
[4] Khalil MM,Tremoleda JL,Bayomy TB,et al.Molecular SPECT Imaging:An Overview[J/OL].Int J Mol Imaging,2011,2011:796025.[2011-07-24].http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094893/.
[5] Young KJ,Jun OS,Sook RJ,et al.Synthesis of 99mTc(CO)3-deoxyuridine derivatives as potential HSV1-tk gene expression imag-ing agents.Appl Radiat Isot,2008,66(4):489-496.
[6] Chin FT,Namavari M,Levi J,et al.Semiautomated radiosynthesis and biological evaluation of [18F] FEAU:a novel PET imaging agent for HSV1-tk/sr39tk reporter gene expression.Mol Imaging Biol,2008,10(2):82-91.
[7] Cai H,Yin D,Zhang L,et al.Preparation and biological evaluation of 2-amino-6-[18F] fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl) purine(6-[18F]FPCV) as a novel PET probe for imaging HSV1-tk reporter gene expression.Nucl Med Biol,2007,34(6):717-725.
[8] Cho SY,Havasi L,Szajek LP,et al.Evaluation of 76Br-FBAU as a PET reporter probe for HSV1-tk gene expression imaging using mouse models of human glioma.J Nucl Med,2005,46(11):1923-1930.
[9] Alauddin MM,Shahinian A,Gordon EM,et al.Direct comparison of radiolabeled probes FMAU,FHBG,and FHPG as PET imaging agents for HSV1-tk expression in a human breast cancer model.Mol Imaging,2004,3(2):76-84.
[10] Liang Q,Gotts J,Satyamurthy N,et al.Noninvasive,repetitive,quantitative measurement of gene expression from a bicistronic message by positron emission tomography,following gene transfer with adenovirus.Mol Ther,2002,6(1):73-82.
[11] Vadysirisack DD,Shen DH,Jhiang SM.Correlation of Na+/I- symporter expression and activity:implications of Na+/I- symporter as an imaging reporter gene.J Nucl Med,2006,47(1):182-190.
[12] Anton M,Wagner B,Haubner R,et al.Use of the norepinephrine transporter as a reporter gene for non-invasive imaging of genetically modified cells.J Gene Med,2004,6(1):119-126.
[13] Lewis MR.A "new" reporter in the field of imaging reporter genes:correlating gene expression and function of the sodium/iodide symporter.J Nucl Med,2006,47(1):1-3.
[14] Bogdanov A Jr,Petherick P,Marecos E,et al.In vivo localization of diglycylcysteine-bearing synthetic peptides by nuclear imaging of oxotechnetate transchelation.Nucl Med Biol,1997,24(8):739-742.
[15] Northrop JP,Bednarski M,Barbieri SO,et al.Cell surface expression of single chain antibodies with applications to imaging of gene expression in vivo.Eur J Nucl Med Mol Imaging,2003,30(9):1292-1298.
[16] Pfannenberg C,Aschoff P,Dittmann H,et al.PET/CT with 18F-FLT:does it improve the therapeutic management of metastatic germ cell tumors?.J Nucl Med,2010,51(6):845-853.
[17] Smith RA,Guleryuz S,Manning HC.Molecular imaging metrics to evaluate response to preclinical therapeutic regimens.Front Biosci,2011,16:393-410.
[18] Vande VG,Baekelandt V,Dresselaers T,et al.Magnetic resonance imaging and spectroscopy methods for molecular imaging.Q J Nucl Med Mol Imaging,2009,53(6):565-585.
[19] Lecchi M,Ottobrini L,Martelli C,et al.Instrumentation and probes for molecular and cellular imaging.Q J Nucl Med Mol Imaging,2007,51(2):111-126.
[20] Ye F,Wu X,Jeong EK,et al.A peptide targeted contrast agent specific to fibrin-fibronectin complexes for cancer molecular imaging with MRI.Bioconjug Chem,2008,19(12):2300-2303.
[21] Hengerer A,Grimm J.Molecular magnetic resonance imaging [J/OL].Biomed Imaging Interv J,2006,2(2):e8.[2011-07-24].http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097616/.
[22] Liu W,Dahnke H,Rahmer J,et al.Ultrashort T2* relaxometry for quantitation of highly concentrated superparamagnetic iron oxide(SPIO) nanoparticle labeled cells.Magn Reson Med,2009,61(4):761-766.
[23] Daldrup-Link HE,Brasch RC.Macromolecular contrast agents for MR mammography:current status.Eur Radiol,2003,13(2):354-365.
[24] Glunde K,Artemov D,Penet MF,et al.Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer.Chem Rev,2010,110(5):3043-3059.
[25] Kiessling F,Gaetjens J,Palmowski M.Application of molecular ultrasound for imaging integrin expression.Theranostics,2011,1:127-134.
[26] Deshpande N,Needles A,Willmann JK.Molecular ultrasound imaging:current status and future directions.Clin Radiol,2010,65(7):567-581.
[27] Anderson CR,Hu X,Zhang H,et al.Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent.Invest Radiol,2011,46(4):215-224.
[28] Gessner R,Dayton PA.Advances in molecular imaging with ultrasound.Mol Imaging,2010,9(3):117-127.
[29] Voigt JU.Ultrasound molecular imaging.Methods,2009,48(2):92-97.
[30] Ntziachristos V,Bremer C,Weissleder R.Fluorescence imaging with near-infrared light:new technological advances that enable in vivo molecular imaging.Eur Radiol,2003,13(1):195-208.
[31] Hilderbrand SA,Weissleder R.Near-infrared fluorescence:application to in vivo molecular imaging.Curr Opin Chem Biol,2010,14(1):71-79.
[32] Qin C,Zhu S,Tian J.New optical molecular imaging systems.Curr Pharm Biotechnol,2010,11(6):620-627.
[33] Popovtzer R,Agrawal A,Kotov NA,et al.Targeted gold nanoparticles enable molecular CT imaging of cancer.Nano Lett,2008,8(12):4593-4596.
[34] Wyss C,Schaefer SC,Juillerat-Jeanneret L,et al.Molecular imaging by micro-CT:specific E-selectin imaging.Eur Radiol,2009,19(10):2487-2494.
[35] Montet X,Pastor CM,Vallee JP,et al.Improved visualization of vessels and hepatic tumors by micro-computed tomography(CT) using iodinated liposomes.Invest Radiol,2007,42(9):652-658.
[36] Pan D,Roessl E,Schlomka JP,et al.Computed tomography in color:NanoK-enhanced spectral CT molecular imaging.Angew Chem Int Ed Engl,2010,49(50):9635-9639.
[37] Lucignani G.PET-MRI synergy in molecular,functional and anatomical cancer imaging.Eur J Nucl Med Mol Imaging,2008,35(8):1550-1553.
[38] Schiepers C,Dahlbom M.Molecular imaging in oncology:the aceptance of PET/CT and the emergence of MR/PET imaging.Eur Radiol,2011,21(3):548-554.
[39] Sauter AW,Wehrl HF,Kolb A,et al.Combined PET/MRI:one step further in multimodality imaging.Trends Mol Med,2010,16(11):508-515.

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备注/Memo

备注/Memo:
收稿日期:2011-07-26。
通讯作者:张永学(Email:zhyxl229@163.com)
更新日期/Last Update: 1900-01-01