[1]蔡汉成,尹端沚,张岚,等.早期诊断阿尔茨海默病的PET分子探针[J].国际放射医学核医学杂志,2006,30(4):202-205.
 CAI Han-cheng,YIN Duan-zhi,ZHANG Lan,et al.PET molecular probes for early detection of Alzheimer’s disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(4):202-205.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第4期
页码:
202-205
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
PET molecular probes for early detection of Alzheimer’s disease
作者:
蔡汉成 尹端沚 张岚 李谷才 郑明强 汪勇先
201800 上海, 中国科学院上海应用物理研究所放射性药物研究中心
Author(s):
CAI Han-cheng YIN Duan-zhi ZHANG Lan LI Gu-cai ZHENG Ming-qiang WANG Yong-xian
Research Center of Radiopharmaceuticals Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Shanghai 201800, China
关键词:
阿尔茨海默病体层摄影术发射型计算机分子探针淀粉样β蛋白受体胆碱能
Keywords:
lzheimer’s diseaseTomography emission-computedMolecular probeAamyloid β-proteinRecepter cholinergic
分类号:
R817.4
摘要:
阿尔茨海默病(AD)是一种退行性神经功能障碍性疾病,其典型病理学特征是β-淀粉样蛋白斑块、神经纤维缠结和基底前脑乙酰胆碱能损害。PET分子探针,特别是靶向β-淀粉样蛋白斑块、乙酰胆碱酯酶或受体显像的分子探针是最可靠的AD早期检测手段之一。
Abstract:
Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder. The characteristic pathological lesions are deposits of β-amyloid plaques and neurofibrillary tangles after postmortem examination, and degeneration of cholinergic neurons of the basal forebrain. The positron emission tomography (PET) molecular probes targeting at β-amyloid plaques or acetylchergic is one of the most reliable tools for AD early detection.

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备注/Memo

备注/Memo:
收稿日期:2006-02-25。
基金项目:中国科学院知识创新工程重大项目(KJCXI-SW-08):上海市自然科学基金项目(02ZB14061)
通讯作者:蔡汉成,E-mail:chcbati@yahoo.com.cn
更新日期/Last Update: 1900-01-01