[1]郭喆,张锦明.阿尔茨海默病的放射性分子显像探针研究进展[J].国际放射医学核医学杂志,2006,30(4):199-202.
 GUO Zhe,ZHANG Jin-ming.Study on radioactive labeling of molecular probes for Alzheimer’s disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(4):199-202.
点击复制

阿尔茨海默病的放射性分子显像探针研究进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第4期
页码:
199-202
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Study on radioactive labeling of molecular probes for Alzheimer’s disease
作者:
郭喆 张锦明
100853 北京, 解放军总医院核医学科
Author(s):
GUO Zhe ZHANG Jin-ming
Department of Nuclear Medicine, The PLA General Hospital, Beijing 100853, China
关键词:
阿尔茨海默病老年斑β-淀粉样蛋白体层摄影术发射型计算机
Keywords:
Alzheimer’s diseaseSenile plaquesβ-amyloid proteinTomo emission computed
分类号:
R817.4
摘要:
阿尔茨海默病(AD)是引起痴呆的最常见类型之一,其主要病理改变包括由β-淀粉样蛋白构成的老年斑、神经原纤维缠结。在体观察AD脑内的β-淀粉样蛋白沉积,可为AD的诊断、疗效观察和治疗药物的研究提供很大帮助。目前已合成数种标记β-淀粉样蛋白的放射性探针并开始用于PET对AD患者脑内老年斑的在体显像研究,并显示出潜在的临床应用价值。AD的放射性分子显像探针仍需进一步研究,使其不仅适用于PET,而且还可以满足SPECT的显像要求。
Abstract:
Alzheimer’s disease (AD) is the most common form of dementia, the pathological features of AD include neuritic plaques composed of beta-amyloid protein, neurofibrillary tangles. Direct imaging of amyloid load in patients with AD in vivo would be useful for the early diagnosis of AD and the development and assessment of new treatment strategies. Different strategies are being used to develop compounds suitable for in vivo imaging of amyloid deposits in human brains. Two compounds, 18F-FDDNP and 11C-PIB, both show more binding in the brains of patients with AD than in those of healthy people. Additional compounds will probably be developed that are suitable not only for PET but also for single photon emission CT (SPECT).

参考文献/References:

1 盛树力.老年性痴呆:从分子生物学到临床诊治.北京:科学技术出版社,1998.61-73.
2 Jarrett JT,Berger EP,Lansbury PT Jr,et al.The carboxy terminus of the β-amyloid protein is critical for the seeding of amyloid formation:implications for the pathogenesis of Alzheimer’s disease.Biochemistry,1993,32(18):4693-4697.
3 Wisiniewski TM,Wadghiri YZ.Detection of Alzheimer’s amyloid by magnetic resonance imaging.Proceedings of the Society for Neuroscience,31st Annual Meeting,2001.
4 Friedland RP,Kalaria R,Berridge M,et al.Neuroimaging of vessel amyloid in Alzheimer’s disease.Ann NY Acad Sci,1997,826:242-247.
5 Zhuang ZP,Kung MP,Hou C,et al.Radioiodinated styrylbenzenes and thio flavins as probes for amyloid aggregates.J Med Chem,2001,44(12):1905-1914.
6 Mathis CA,Holt DP.In vivo evalution and imaging of a lipohilic derivative of Congo red for amyloid assessment.J Nucl Med,2001,42:252.
7 Klunk WE,Bacskai BJ,Mathis CA,et al.Imaging amyloid-beta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04,a systemically administered Congo red derivative.J Neuropathol Exp Neurol,2002,61(9):797-805.
8 Klunk WE,Wang Y,Huang GF,et al.Uncharged thioflavin-t derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.Life Sci,2001,69(13):1471-1484.
9 Kung MP,Hou C,Zhuang ZP,et al.IMPY:an improved thioflavin-T derivative for in vivo labeling of β-amyloid plaques.Brain Res.2002,956(2):202-210.
10 Zhuang ZP,Kung MP,Wilson A,et al.Structure-activity relationship of imidazo[1,2-a] pyridines as ligands for detecting β-amyloid plaques in the brain.J Med Chem,2003,46(2):237-243.
11 Agdeppa ED,Kepe V,Liu J,et al.Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethyl-idene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer’sdisease.J Neurosci,2001,21(24):RC189.
12 Agdeppa ED,Kepe V,Liu J,et al.2-Dialky lamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs):novel diagnostic and therapeutic tools in Alzheimer’s disease.Mol Imaging Biol,2003,5(6):404-417.
13 Shoghi-Jadid K,Small GW,Agdeppa ED,et al.Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease.Am J Geriatr Psychiatry,2002,10(1):24-35.
14 Jagust W.The proteomics of positron emission tomography.Ann Neurol,2004,55(3):303-305.
15 Klunk WE,Engler H,Nordberg A,et al.Imaging brain amyloid in Alzheimer’s disease with pittsburgh compound-B.Ann Neurol,2004,55(3):306-319.
16 Schmitt FA,Davis DG,Wekstein DR,et al."Preclinical" AD revisited: neuropathology of cognitively normal older adults.Neurology,2000,55(3):370-376.

相似文献/References:

[1]胡伟,赵军.小胶质细胞在AD炎性机制中的作用及其常见PET显像剂的应用进展[J].国际放射医学核医学杂志,2016,40(1):44.[doi:10.3760/cma.j.issn.1673-4114.2016.01.009]
 Hu Wei,Zhao Jun.Microglia’s Alzheimer disease inflammatory mechanisms and progress of its common application in PET imaging agents[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):44.[doi:10.3760/cma.j.issn.1673-4114.2016.01.009]
[2]段小艺,李淼,王黎,等.阿尔茨海默病PET正电子药物应用与研究进展[J].国际放射医学核医学杂志,2014,38(5):318.[doi:10.3760/cma.j.issn.1673-4114.2014.05.010]
 Duan Xiao-yi,Li Miao,Wang Li,et al.Application and research progress of PET positron tracers associated with Alzheimer disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(4):318.[doi:10.3760/cma.j.issn.1673-4114.2014.05.010]
[3]王新艳,管一晖.阿尔茨海默病的影像学诊断进展[J].国际放射医学核医学杂志,2013,37(1):52.[doi:10.3760/cma.j.issn.1673-4114.2013.01.014]
 WANG Xin-yan,GUAN Yi-hui.The advancement in Alzheimer disease of imaging diagnosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(4):52.[doi:10.3760/cma.j.issn.1673-4114.2013.01.014]
[4]孔艳艳,管一晖,吴平.PET分子探针在阿尔茨海默病早期诊断中的研究进展[J].国际放射医学核医学杂志,2012,36(5):257.[doi:10.3760/cnla.j.issn.1673-4114.2012.05.001]
 KONG Yan-yan,GUAN Yi-hui,WU Ping.Novel PET molecular probes for early diagnosis of Alzheimer’s disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(4):257.[doi:10.3760/cnla.j.issn.1673-4114.2012.05.001]
[5]王颖,蔡莉,李彦生,等.11C-PIB PET在不同时期阿尔茨海默病中的研究进展[J].国际放射医学核医学杂志,2013,37(6):378.[doi:10.3760/cma.j.issn.1673-4114.2013.06.013]
 WANG Ying,CAI Li,LI Yan-sheng,et al.Application of 11C-PIB PET in different period of the Alzheimer disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(4):378.[doi:10.3760/cma.j.issn.1673-4114.2013.06.013]
[6]张冰,徐俊,徐运,等.fMRI在阿尔茨海默病、额颞叶痴呆及路易体痴呆中的研究进展[J].国际放射医学核医学杂志,2010,34(5):303.[doi:10.3760/cma.j.issn.1673-4114.2010.05.015]
 ZHANG Bing,XU Jun,XU Yun,et al.The study of fMRI in Alzheimer’s disease, frontotemporal dementia and Lewy bodies dementia[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(4):303.[doi:10.3760/cma.j.issn.1673-4114.2010.05.015]
[7]陈贵兵,吴华,彭添兴.正电子显像剂11C-匹兹堡化合物B的化学合成及其临床应用[J].国际放射医学核医学杂志,2008,32(3):158.
 CHEN Gui-bing,WU Hua,PENG Tian-xing.Chemical synthesis and clinical application of a new positron imaging agent 11C-Pittsburgh compound-B[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(4):158.
[8]袁瑛,顾兆祥.放射性核素显像在轻度认知功能障碍中的应用价值[J].国际放射医学核医学杂志,2008,32(4):209.
 YUAN Ying,GU Zhao-xiang.Applications of radionuclide imaging in mild cognitive impairment[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(4):209.
[9]蔡汉成,尹端沚,张岚,等.早期诊断阿尔茨海默病的PET分子探针[J].国际放射医学核医学杂志,2006,30(4):202.
 CAI Han-cheng,YIN Duan-zhi,ZHANG Lan,et al.PET molecular probes for early detection of Alzheimer’s disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(4):202.
[10]李祖贵.轻度认知障碍的功能性神经影像学研究进展[J].国际放射医学核医学杂志,2006,30(2):76.
 LI Zu-gui.The progress of functional neuroimaging in the study of mild cognitive impairment[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(4):76.

备注/Memo

备注/Memo:
收稿日期:2005-10-14。
通讯作者:张锦明,E-mail:zhangjm301@yahoo.com.cn
更新日期/Last Update: 1900-01-01