[1]张娟,唐志刚,王学斌.99mTc-葡糖二酸显像剂的研究进展[J].国际放射医学核医学杂志,2006,30(4):196-198.
　ZHANG Juan,TANG Zhi-gang,WANG Xue-bin.The advanced in 99mTc labeled glucaric acid[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(4):196-198.
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99mTc-葡糖二酸显像剂的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第4期
页码:
196-198
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The advanced in 99mTc labeled glucaric acid
作者:
张娟;  唐志刚;  王学斌
100875 北京, 北京师范大学化学学院教育部放射性药物重点实验室
Author(s):
ZHANG Juan;  TANG Zhi-gang;  WANG Xue-bin
Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China
关键词:
葡糖二酸; 锝-99m; 药盒; 心肌梗死; 乳腺肿瘤
Keywords:
Glucaric acid; Technetium-99m; Kit; Myocardiol infarction; Breast neoplasms
分类号:
R817.4
摘要:
葡糖二酸(GLA)是一种六碳二元羧酸盐的葡萄糖类似物,是葡萄糖在生物体内代谢的产物之一,存在于组织和体液中,可被99mTc标记。本文论述了GLA的制备、99mTc-GLA药盒的制备以及99mTc-GLA在心肌梗死显像和肿瘤显像中的研究进展。现有的研究结果表明,99mTc-GLA在诊断心肌梗死和某些肿瘤(如乳腺癌)表现了良好的性质,因此是一种很有应用前景和研究价值的显像剂。
Abstract:
Glucaric acid (GLA) is a six-carbon dicarboxylic acid sugar, one of the natural endogenous end-eatabolite of glueose, whieh is normally present in tissues and body fluids. It ean be labeled with 99mTc. In this review we diseuss the synthesis of GLA and the investigation of 99mTc-GLA inelude the preparation of the kit, myocardiol infarction imaging and some tumor imaging (espeeially in breast tumor imaging). All the researches suggest that 99mTc-GLA is a potential imaging for myocardiol infarction imaging and tumor imaging.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2005-10-18。
通讯作者:王学斌,E-mail:xbwang@bnu.edu.cn
更新日期/Last Update: 1900-01-01