[1]段小艺,李淼,王黎,等.阿尔茨海默病PET正电子药物应用与研究进展[J].国际放射医学核医学杂志,2014,38(5):318-322.[doi:10.3760/cma.j.issn.1673-4114.2014.05.010]
 Duan Xiao-yi,Li Miao,Wang Li,et al.Application and research progress of PET positron tracers associated with Alzheimer disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(5):318-322.[doi:10.3760/cma.j.issn.1673-4114.2014.05.010]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第5期
页码:
318-322
栏目:
出版日期:
2014-09-25

文章信息/Info

Title:
Application and research progress of PET positron tracers associated with Alzheimer disease
作者:
段小艺1 李淼1 王黎1 李宏利2 赵周社2 郭佑民1
1. 西安交通大学第一附属医院PET/CT室, 710061;
2. GE医疗系统集团, 中国, 北京, 100176
Author(s):
Duan Xiao-yi1 Li Miao1 Wang Li1 Li Hong-li2 Zhao Zhou-she2 Guo You-min1
Department of PET/CT, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
关键词:
阿尔茨海默病正电子发射断层显像术正电子药物
Keywords:
Alzheimer diseasePositron-emission tomographyRadiotracer
DOI:
10.3760/cma.j.issn.1673-4114.2014.05.010
摘要:
阿尔茨海默病(AD)严重危害人们的身心健康。伴随PET分子成像的发展,出现了一系列针对AD的正电子药物,其中匹兹堡化合物B(PIB)及其衍生物类PET正电子药物研究最为成熟,部分已获准应用于临床,在AD诊断与治疗方面显示出重要价值。随着人们对AD发生机制研究的不断深入,近年又相继出现了包括蛋白类、受体类以及肽类在内的更多种类AD相关PET正电子药物。该文就此类正电子药物的应用与研究进展做一综述。
Abstract:
Alzheimer disease (AD)harms human being’s health seriously. With the development progress of PET molecular imaging, a series of PET positron tracers associated with AD appeard. Among them, pittsburgh compound-B (PIB)and PIB derivatives are studied more deeply and part of them have been used in clinic which are showing great value in diagnosis and therapy of AD. Recently, with the deeper research of AD mechanism, more kinds of PET tracers related to AD are developed, including protein, receptor and peptide radiotracers. This article reviews the current application and research progress of those PET positron tracers which associated with AD.

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备注/Memo

备注/Memo:
收稿日期:2014-02-18。
通讯作者:段小艺(Email:duanxy@mail.xjtu.edu.cn)
更新日期/Last Update: 1900-01-01