[1]姚立新,李昨非,刘波,等.99Tcm-DTPA核素肾动态显像对糖尿病肾功能的评价[J].国际放射医学核医学杂志,2009,33(6):343-346.[doi:10.3760/cma.j.issn.1673-4114.2009.06.007]
　YAO Li-xin,LI Zuo-fei,LIU Bo,et al.99Tcm-DTPA renal dynamic imaging in judgment of renal functions in patients with diabetes mellitus[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(6):343-346.[doi:10.3760/cma.j.issn.1673-4114.2009.06.007]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第6期
页码:
343-346
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
99Tcm-DTPA renal dynamic imaging in judgment of renal functions in patients with diabetes mellitus
作者:
姚立新1;  李昨非2;  刘波3;  郭雷鸣1
1. 秦皇岛市第一医院核医学科, 秦皇岛 066000;
2. 秦皇岛市第一医院功能科, 秦皇岛 066000;
3. 秦皇岛市第一医院内分泌科, 秦皇岛 066000
Author(s):
YAO Li-xin1;  LI Zuo-fei2;  LIU Bo3;  GUO Lei-ming1
1. Department of Nuclear Medicine, Qinhuangdao 066000, China;
2. Department of Function, Qinhuangdao 066000, China;
3. Department of Incretion, Qmhuangdao the First Hospital, Qinhuangdao 066000, China
关键词:
糖尿病肾病; 放射性核素显像; 99m锝五乙酸盐; 肾小球滤过率
Keywords:
Diabetic nephropathies; Radionuclide imaging; Techenetium Tc 99m pentetate; Glomerular filtration rate
DOI:
10.3760/cma.j.issn.1673-4114.2009.06.007
摘要:
目的 探讨,99Tcm-二亚乙基三胺五乙酸(99Tcm-DTPA)核素肾动态显像诊断糖尿病肾病(DN)的价值。方法 糖尿病(DM)患者90例,依据尿白蛋白排泄率(UAER)分为4组:①DM正常尿白蛋白(DM1)组;②DM微量尿白蛋白(DM2)组;③大量尿白蛋白(DM3)组;④肾功能不全(DM4)组;与正常对照(NC)组40例一起行放射性核素动态显像测定肾小球滤过率(GFR),同时测定尿素氮(BUN)、血清肌酐(SCr)、β2-微球蛋白(β2-MG)。结果 DM1组GFR明显高于NC组(t=12.5,P<0.01),DM2组GFR与NC组相比无差异,但肾功能曲线半排时间(T1/2)延长,20min残流率(C20)增高。DM3、DM4组GFR明显低于对照组,T1/2更加延长,C20更高,随着DN的进展,UAER逐渐上升,GFR依次降低,二者呈显着负相关(r=-0.497,P<0.05)。结论 99Tcm=DTPA肾动态显像可早期诊断DN,并可了解肾功能受损程度,是反映DN损害的敏感指标。
Abstract:
Objective To evaluate 99Tcm-diethylenetriamine-pentaacetic acid(99Tcm-DTPA) renal dynamic imaging in judgment of the renal function inpatients with diabetes mellitus(DM) so as to provide reference for clinical treatment and prognosis predicting. Methods Ninety patients with DM were divided into four groups according to the values of urinary albumin excretion rate(UAER).①Group DM,:UAER<20μg·min-1, 25 cases.②Gruop DM2:UAER 20-200μg·min-1, 24 cases.③Group DM;UAER>200μg·min-1, 23 cases.④a renal function failure group(DM4), 18 cases. Fourty healthy people were chosen as normal control(NC) group.99Tcm-DTPA radionuclide renal dynamic imaging of glcmerular filtration rate(GFR) was performed and the levels of serum creatinine(SCr), blood urea nitrogen(BUN) and blood β2-microglobulin(β2-MG) were measured in the five groups. Results GFR were significantly increased in group DM1 than those in NC(t=12.5, P<0.01).In group DM2 GFR was not different from NC. The half activity time(T1/2) of the renogram was significantly prolonged. The 20 min retention rate(C20) of the renogram increased compared with NC. In group DM3 and DM4, GFR was remarkably decreased. The peak time(TP) of the renogram delayed. T1/2 distinctly prolonged and C20 increased,comparing with NC(r=-0.497,P<0.05). Conclusion Radionuclide renal dynamic imaging is helpful for the evaluation of renal damage in early stage of diabetic nephropathy(DN),judge the injury of the renal function and provide reference for clinical t treatment and follow-up.

参考文献/References:

[1] 张文军.张晓明.肾动态显像对糖尿病肾病患者肾功能的评价.医药论坛杂志,2006,27(20):43-44.
[2] 王晓军,刘文星,徐丽梅,等.2型糖尿病患者肾小球滤过率的改变及影响因素分析.广东医学,2006,27(5):691.
[3] 李建高,徐焱成.核素肾动态显像诊断糖尿病肾病的研究.现代中西民结合杂志,2006,15(6):709.
[4] 张遵城,郑妙瑢,董萍,等.核素肾动态显像对I型糖尿病肾功能研究.中华内分泌代谢杂志,2000,16(6):363.

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备注/Memo

备注/Memo:
收稿日期:2009-05-27。
通讯作者:姚立新(E-mail:yaolixin158@sina.com.cn)
更新日期/Last Update: 1900-01-01