[1]陈跃.前哨淋巴结显像研究[J].国际放射医学核医学杂志,2002,26(4):165-168.
 CHEN Yue.Detection of sentinel nodes by lymphoscintigraphy[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(4):165-168.
点击复制

前哨淋巴结显像研究(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第4期
页码:
165-168
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Detection of sentinel nodes by lymphoscintigraphy
作者:
陈跃
646000 泸州, 泸州医学院附属医院核医学科
Author(s):
CHEN Yue
Department of Nuclear Medicine, Luzhou Medical College Hospital, Sichuan Luzhou 646000, China
关键词:
前哨淋巴结放射性核素显像黑色素瘤乳腺癌
Keywords:
sentinel lymph nodeslymphoscintigraphymelanomabreast cancer
分类号:
R817.4
摘要:
前哨淋巴结系指原发肿瘤淋巴引流的第一级淋巴结,淋巴显像可准确定位前哨淋巴结及其数目,检出率达80%~100%。常用的前哨淋巴结显像剂有99Tcm-硫胶体、99Tcm-人血清白蛋白、99Tcm-右旋糖酐等。该法简便安全、实用性强,已先后应用于黑色素瘤、乳腺癌、妇科肿瘤等疾病的术前常规定位诊断,取得了很好的结果。
Abstract:
Sentinel lymph nodes (SLN)are regional lymph nodes first involved in metastatasis if lymphatic spread occurs.The SLN of solid tumor can be accurately identified by preoperative lymphoscintigraphy.Biopsy of the SLN is a highly precise,minimally invasive method of staging patients.The procedure may lead to a more justifiable approach to adjuvant therapy strategies with low complication.The SLN was identified in 80%~100% patients by lymphoscintigraphy. 99Tcm-sulfur colloid,99Tcm-colloidal albumin and 99Tcm-dextran has been the radiotracer for SLN mapping.Lymphoscintigraphy is a simple procedure that is well tolerated by patients.Until now,lymphoscintigraphy has been shown to effective for preop-erative lymphatic mapping and SLN localization in melanoma,breast cancer,and in other malignancies such as vulvar cancer.

参考文献/References:

[1] Uren RF, Howman-Giles R, Thompson JF. Interval nodes:the forgotten sentinel nodes in patients with melanoma[J]. Arch Surg, 2000, 135(10):1168-1172.
[2] Morita ET, Chang J, Leong SP. Principles and controversies in lymphoscintigraphy with emphasis on breast cancer[J]. Surg Clin North Am, 2000, 80(6):1721-1739.
[3] Krynyckyi BR, Miner M, Ragonese JM. Technical aspects of performing lymphoscintigraphy:optimization of methods used to obtain images[J]. Clin Nucl Med, 2000, 25(12):978-985.
[4] Bedrosian I, Scheff AM, Mick R, et al.99Tcm-human serum albumin:an effective radiotracer for identifying sentinel lymph nodes in melanoma[J]. J Nucl Med, 1999, 40(7):1143-1148.
[5] Valdes-Olmos RA, Jansen L, Hoefnagel CA, et al. Evaluation of mammary lymphoscintigraphy by a single intratumoral injection for sentinel node identification[J]. J Nucl Med, 2000, 41(9):1500-1506.
[6] Tonakie A, Sondak V, Yahanda A, et al. Reproducibility of lymphoscintigraphic drainage patterns in sequential human serum albumin and sulfur colloid studies:implications for sentinel node identification in melanoma[J]. Surgery, 1999, 126(5):955-962.
[7] Boxen I, MeCready D, Ballinger JR. Sentinel node detection and definition may depend on the imaging agent and timing[J]. Clin Nucl Med, 1999, 24(6):390-394.
[8] Liu TJ, Wang SJ, Tsai SC. Lymphoscintigraphy using larger colloid particles may enhance visualization of the sentinel node in breast cancer:a case report[J]. Clin Nucl Med, 2000, 25(3):191-192.
[9] Haigh PI, Hansen NM, Giuliano AE, et al. Factors affecting sentinel node localization during preoperative breast lymphoscintigraphy[J]. J Nucl Med, 2000, 41(10):1682-1688.
[10] Pijpers R, Meijer S, Hoekstra OS, et al. Impact of lymphoscintigraphy on sentinel node identification with technetium-99m-colloidal albumin in breast cancer[J]. J Nucl Med, 1997, 38:366.
[11] Veronesi U, Paganelli G, Galimberti V, et al. Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes[J]. Lancet, 1997, 348:1864-1867.
[12] Offodile R, Hoh C, Barsky SH, et al. Minimally invasive breast carcinoma steging using lymphatic mapping with radiolabeled dextran[J]. Cancer, 1998, 82(9):1704-1708.
[13] Tartaglione G, Potenza C, Caggiati A, et al. Optimization of lymphoscintigraphy in sentinel node biopsy in the staging of malignant melanoma[J]. Radiol Med, 2000, 100(5):367-371.
[14] Paganelli G, De Cicco C, Chinol M. Sentinel node localization by lymphoscintigraphy:a reliable technique with widespread applications[J]. Recent Results Cancer Res, 2000, 157(1):121-129.
[15] Gennari R, Bartolomei M, Testori A. Sentinel node localization in primary melanoma:preoperative dynamic lymphoscintigraphy, intraoperative gamma probe, and vital dye guidance[J]. Surgery, 2000, 127(1):19-25.
[16] Kogut KA, Fleming M, Pappo AS, et al. Sentinel lymph node biopsy for melanoma in young children[J]. J Pediatr Surg, 2000, 35(6):965-966.
[17] Stachowiak AM, Delpassand ES, Levenback C. Lymphoscintigraphy and intraoperative sentinel sentinel node biopsy in cervical cancer[J]. Clin Nucl Med, 2001, 26(3):279.
[18] Verheijen RH, Pijpers R, van Diest PJ, et al. Sentinel node detection in cervical cancer[J]. Obstet Gynecol, 2000, 96(1):135-138.
[19] De Cicco C, Cremonesi M, Luini A, et al. Lymphoscintigraphy and radioguided biopsy of the sentinel axillary node in breast cancer[J]. J Nucl Med, 1998, 39(12):2080-2084.
[20] Sideri M, De Cicco C, Maggioni A, et al. Detection of sentinel nodes by lymphoscintigraphy and gamma probe guided surgery in vulvar neoplasia[J]. Tumori, 2000, 86(4):359-363.
[21] Krag D, Weaver D, Ashikaga T, et al. The sentinel node in breast cancer:a multicenter validation study[J]. New Engl J Med, 1998, 339(14):941-946.

相似文献/References:

[1]邢宇,赵新明.放射性核素标记HER2亲和体分子探针精准诊疗的研究进展[J].国际放射医学核医学杂志,2016,40(2):139.[doi:10.3760/cma.j.issn.1673-4114.2016.02.011]
 Xing Yu,Zhao Xinming.Advances in radionuclide-labeled HER2 affibody molecular probes for precise diagnosis and treatment[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):139.[doi:10.3760/cma.j.issn.1673-4114.2016.02.011]
[2]陈顺军,程兵.肿瘤细胞凋亡核素显像分子探针研究进展[J].国际放射医学核医学杂志,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
 Chen Shunjun,Cheng Bing.Progress in molecular probes of radionuclide tumor apoptosis imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
[3]孙芳芳,张欣.uPAR放射性核素靶向显像研究进展[J].国际放射医学核医学杂志,2016,40(3):230.[doi:10.3760/cma.j.issn.1673-4114.2016.03.013]
 Sun Fangfang,Zhang Xin.Research progress of uPAR-targeted nuclear imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):230.[doi:10.3760/cma.j.issn.1673-4114.2016.03.013]
[4]安淑娴,宋少莉,黄钢.放射性核素标记的凋亡显像剂的研究进展[J].国际放射医学核医学杂志,2015,39(6):470.[doi:10.3760/cma.j.issn.1673-4114.2015.06.008]
 An Shuxian,Song Shaoli,Huang Gang.Recent advances in apoptosis imaging using radionuclide-labeled tracers[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):470.[doi:10.3760/cma.j.issn.1673-4114.2015.06.008]
[5]黄建敏,解朋,刘晓梅,等.以整合素αvβ3为靶点的肿瘤分子显像及靶向治疗[J].国际放射医学核医学杂志,2015,39(3):256.[doi:10.3760/cma.j.issn.1673-4114.2015.03.015]
 Huang Jianmin,Xie Peng,Liu Xiaomei,et al.Integrins αvβ3 in molecular imaging and targeted therapy of neoplasms[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):256.[doi:10.3760/cma.j.issn.1673-4114.2015.03.015]
[6]郭宵峰,刘建中,孙琦婷.肺通气/灌注平面显像与肺灌注SPECT/CT对肺栓塞诊断价值的对比性研究[J].国际放射医学核医学杂志,2015,39(4):277.[doi:10.3760/cma.j.issn.1673-4114.2015.04.001]
 Guo Xiaofeng,Liu Jianzhong,Sun Qiting.Comparative study of pulmonary ventilation/perfusion planar imaging and pulmonary perfusion SPECT combined with low-dose CT in the diagnosis of pulmonary embolism[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):277.[doi:10.3760/cma.j.issn.1673-4114.2015.04.001]
[7]马春旭,袁卫红.甲状腺结节影像学诊断研究进展[J].国际放射医学核医学杂志,2014,38(1):48.[doi:10.3760/cma.j.issn 1673-4114.2014.01.010]
 Ma Chunxu,Yuan Weihong.Advanced research on imaging diagnosis of thyroid nodule[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(4):48.[doi:10.3760/cma.j.issn 1673-4114.2014.01.010]
[8]吕靖,张一帆.核素分子显像监测胚胎干细胞及诱导性多潜能干细胞移植的研究进展[J].国际放射医学核医学杂志,2014,38(2):106.[doi:10.3760/cma.j.issn.1673-4114.2014.02.009]
 Lyu Jing,Zhang Yifan.Advances in radionuclide imaging of monitoring embryonic stem cells and induced pluripotent stem cells transplantation[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(4):106.[doi:10.3760/cma.j.issn.1673-4114.2014.02.009]
[9]高平,王茜,赵赟赟,等.99Tcm-MDP SPECT/CT显像用于骨肉瘤肺转移的诊断[J].国际放射医学核医学杂志,2014,38(3):148.[doi:10.3760/cma.j.issn.1673-4114.2014.03.002]
 Gao Ping,Wang Qian,Zhao Yunyun,et al.99Tcm-MDP SPECT/CT used in diagnosis of pulmonary metastasis from osteosarcoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(4):148.[doi:10.3760/cma.j.issn.1673-4114.2014.03.002]
[10]郝玉美,贺欣,宋娜玲.靶向肿瘤新生血管整合素αvβ3受体显像研究现状及进展[J].国际放射医学核医学杂志,2014,38(3):179.[doi:10.3760/cma.j.issn.1673-4114.2014.03.010]
 Hao Yumei,He Xin,Song Naling.Progress on tumor angiogenesis imaging targeting integrin αvβ3 receptor[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(4):179.[doi:10.3760/cma.j.issn.1673-4114.2014.03.010]
[11]马乐,张万春,李晓敏.乳腺癌前哨淋巴结核素显像新进展[J].国际放射医学核医学杂志,2016,40(2):145.[doi:10.3760/cma.j.issn.1673-4114.2016.02.012]
 Ma Le,Zhang Wanchun,Li Xiaomin.Evolution of radionuclide imaging of sentinel node lymphscintigraphy in breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):145.[doi:10.3760/cma.j.issn.1673-4114.2016.02.012]
[12]刘志军.头颈部肿瘤前哨淋巴结放射性核素探测研究进展[J].国际放射医学核医学杂志,2006,30(2):91.
 LIU Zhi-jun.Detection of sentinel lymph nodes in head and neck carcinoma by lymphoscintigraphy and gamma probe[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(4):91.
[13]陈璟,吴华.乳腺癌前哨淋巴结探查的研究进展[J].国际放射医学核医学杂志,2002,26(5):222.
 CHEN Jing,WU Hua.Sentinel lymph node detection in breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(4):222.

备注/Memo

备注/Memo:
收稿日期:2001-04-09。
作者简介:陈跃(1968-),男,四川富顺人,副教授,硕士,主要从事肿瘤核医学研究。
更新日期/Last Update: 1900-01-01