[1]王浩,施培基,周晓靓,等.RGD肽及其衍生物在肿瘤显像及治疗中的研究进展[J].国际放射医学核医学杂志,2007,31(5):274-277.
 WANG Hao,SHI Pei-ji,ZHOU Xiao-liang,et al.Research development on RGD peptides and its devivates in tumor imaging and therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(5):274-277.
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RGD肽及其衍生物在肿瘤显像及治疗中的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第5期
页码:
274-277
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Research development on RGD peptides and its devivates in tumor imaging and therapy
作者:
王浩 施培基 周晓靓 王荣先
300192 天津, 中国医学科学院放射医学研究所药物研究室
Author(s):
WANG Hao SHI Pei-ji ZHOU Xiao-liang WANG Rong-xian
Department of pharmacy, Institute of Radiation Medicine, Chinese Academy of Medical Sciences. Tianjin 300192, China
关键词:
肽类放射性核素显像药物疗法药物载体精氨酸-甘氨酸-天冬氨酸肽
Keywords:
PeptidesRadionuclide imagingDrug therapyDrug carriersArginine-glycineaspartic acid
分类号:
Q516;R730.5
摘要:
精氨酸-甘氨酸-天冬氨酸(RGD)肽存在于多种生物细胞外基质中,能特异性识别细胞表面整合素并与之结合,从而介导多种重要的生命活动.外源性RGD肽与肿瘤细胞表面整合素结合后,可作为体内RGD肽类物质的竞争性抑制剂,抑制肿瘤细胞与细胞外基质的黏附与迁移、抑制肿瘤血管形成、诱导肿瘤细胞凋亡,且具有靶向性标记肿瘤显像以及作为抗肿瘤药物和基因治疗的靶向性传导系统的作用.
Abstract:
RGD peptides exist in extracelular matrix of many kinds of organisms,and they can specificly recognise and combin with integrin receptors. After combining with integrin receptors, extrinsic RGD peptides can prevent tumor cells them adhering and migrating, suppress agiogenesis and induce trunor cells apoptosis. And the derivates of RGD peptides can be used as specific imaging libelling and targetal drug dilivery system for tumor therapy.

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备注/Memo

备注/Memo:
收稿日期:2007-03-27。
通讯作者:王浩(E-mail:thriller_wh@hotmail.com)
更新日期/Last Update: 1900-01-01