[1]刘光伟,龚守良.电离辐射诱导的细胞G2期阻滞[J].国际放射医学核医学杂志,2002,26(4):180-182.
　LIU Guang-wei,GONG Shou-liang.G2 phase arrest of cell cycle induced by ionizing radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(4):180-182.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第4期
页码:
180-182
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
G2 phase arrest of cell cycle induced by ionizing radiation
作者:
刘光伟;  龚守良
130021 吉林长春, 吉林大学卫生部放射生物学重点实验室
Author(s):
LIU Guang-wei;  GONG Shou-liang
MH Radiobiology Research Unit, Jilin University, Jilin Changchun 130021, China
关键词:
G2期阻滞; 电离辐射; 细胞周期调控点
Keywords:
G2 phase arrest; ionizing radiation; cell cycle checkpoint
分类号:
Q253;Q345.2
摘要:
哺乳动物受X射线照射后,可以使细胞周期延迟或阻滞,包括G1期阻滞、S期延迟和G2期阻滞。G1期阻滞仅在野生型p53基因存在时出现,在清除DNA损伤的细胞中具有重要作用;而G2期阻滞更有利于损伤后DNA的修复和细胞存活,并且与p53基因存在状态无关。因此,对电离辐射诱导细胞G2期阻滞机制的探讨成为近年来国内外放射生物学领域的研究热点。
Abstract:
The exposure of mammalian cells to X rays results in the prolongation of the cell cycle,including the delay or the arrest in G1,S and G2 phase.The major function of G1 arrest may be to eliminate the cells containing DNA damage and only occurs in the cells with wild type p53 function whereas G2 arrest following ionizing radiation has been shown to be important in protecting the cells from death and occurs in all cells regardless of p53 status.So the study on G2 phase arrest of the cell cycle induced by ionizing radiation has currently become a focus at radiobiological fields.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2002-05-28。
作者简介:刘光伟(1973-),男,吉林白城人,博士研究生,主要从事电离辐射生物效应的研究;龚守良(1945-),男,吉林长春人,教授,博士生导师,主要从事电离辐射生物效应的研究。
更新日期/Last Update: 1900-01-01