[1]陆颖.辐射诱发的旁效应研究[J].国际放射医学核医学杂志,2001,25(5):225-228.
 LU Ying.Study on bystander effects induced by radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(5):225-228.
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辐射诱发的旁效应研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第5期
页码:
225-228
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Study on bystander effects induced by radiation
作者:
陆颖
100850 北京, 军事医学科学院放射医学研究所
Author(s):
LU Ying
Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China
关键词:
辐射旁效应细胞外因子缝隙连接
Keywords:
radiationbystander effectextracellular factorsgap junction
分类号:
Q274
摘要:
辐射能使受照细胞产生基因突变、基因表达水平改变、细胞生长改变等多种生物学效应,但研究发现,类似的反应在与受照细胞共同培养的未受照细胞中也能发生,即产生了旁效应。目前对于旁效应发生机制的了解还很少,可能与细胞间通讯及细胞外的一些因子有关。
Abstract:
Radiation can cause a lot of biological effects in irradiated cells, such as mutations,changes of gene expression, cell growth and so on. But these effects can also be observed in non-irradiated cells. This phenomenon is termed as bystander effect. Up to now, the mechanisms of bystander effects have been known very little. It is believed that extracellular factors or intercellular communications play a very important role in the process.

参考文献/References:

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[4] Mothersill C, Seymour C. Mediun from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells[J]. Int J Radiat Res, 1997, 71(4):421-427.
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[7] Mothereill C, Stamato TD, Perez ML. Involvement of energy metabolism in the production of bystander effects’by radiation[J]. Br J Cancer, 2000, 82(10):1740-1746.
[8] Lehnert BE, Goodwin EH. Extracellular factor(s) following exposure to α particles can cause sister chromatid exchanges in normal human cells[J]. Cancer Res, 1997, 57(11):2164-2171.
[9] Narayanan PK, Goodwin EH, Lehnert BE. α particles initiate biological production of superoxide anions and hydrogen peroxide in human cells[J]. Cancer Res, 1997, 57(18):3963-3971.
[10] Kroemer G. The proto-oncogene bcl-2 and its role in regulating apoptosis[J]. Nat Med, 1997, 3(6):614-620.
[11] Mothersill C. Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes:evidence for release during irradiation of a signal controlling survival into the medium[J]. Radiat Res, 1998, 149(3):256-262.
[12] Azzam ED, Toledo SMD, Gooding T, et al. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles[J]. Radiat Res, 1998, 150:497-504.
[13] Grosovsky A. Radiation-induced mutations in unirradiated DNA[J]. Proc Natl Acad Sci USA, 1999, 96:5346-5347.

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备注/Memo

备注/Memo:
收稿日期:2000/3/21。
作者简介:陆颖(1975-),女,黑龙江佳木斯人,军事医学科学院放射医学研究所硕士研究生,主要从事放射生物学研究。
更新日期/Last Update: 1900-01-01