[1]庄永志,王俊杰.放疗抑制血管成形术后再狭窄的研究进展[J].国际放射医学核医学杂志,2001,25(5):228-232.
　ZHUANG Yong-zhi,WANG Jun-jie.Advances of radiotherapy to prevent restenosis after coronary balloon angioplasty[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(5):228-232.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第5期
页码:
228-232
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Advances of radiotherapy to prevent restenosis after coronary balloon angioplasty
作者:
庄永志;  王俊杰
100083 北京, 北京大学第三医院肿瘤治疗中心
Author(s):
ZHUANG Yong-zhi;  WANG Jun-jie
Department of Oncology the Third Hospital of Beijing University, Beijing 100083, China
关键词:
放疗; 再狭窄; 平滑肌细胞; 经皮穿刺冠状动脉成形术
Keywords:
radiotherapy; restenosis; vascular smooth muscle cells; percutaneous transluminal coronary angioplasty
分类号:
Q274;R817.8
摘要:
放疗预防PTCA后再狭窄的临床应用取得了令人瞩目的疗效。近年来人们在基础和临床方面做了许多深入细致的研究工作。这些工作主要集中在:放疗抑制再狭窄的机制;放疗的时间点、剂量和剂量率;照射方式以及放疗所产生的副作用等。
Abstract:
Radiotherapy is a promising technique to substantianlly reduce the post-PTCA. restenosis Many study work has been done in recent years. These work are mainly focused on the mechanism of inhibiting restenosis by radiation: the time,dose, dose rate, the form and the side effects of radiotherapy.

参考文献/References:

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[2] Mintz GS, Popma JJ, Pichard AD, et al. Anerial remodeling after coronary angioplasty[J]. Circulation, 1996, 94:35-43.
[3] Wilcox JN, Waksman R, King SB, et al. The role of the adventitia in the arterial response to angioplasty[J]. Int J Radiat Oncol Biol Phys, 1996, 36:789-796.
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[5] Verin V, Popowski Y, Bochaton-Piallat ML. Intraarteral beta irradiation induces smooth muscle cell apoptosis and reduces medial cellularity in a hypercholesterolemic rabbit restenosis model[J]. Int J Radiat Oncol Biol Phys, 2000, 46:661-670.
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[7] Powers BE, Thams HD, Gillette EL. Long-term adverse effects of radiation ihhibition of restenosis[J].Int J Radiat Oncol Biol Phys, 1999, 45:753-759.
[8] Laird JR, Carter AJ, Kufs WM, et al. Inhibition of neointimal proliferation with low-dose irradiation from a beta-particle emitting stent[J]. Circulation, 1996, 93:529-536.
[9] Vitali V. Eendoluminal β-radiation therapy for the prevention of coronary restenosis after baloon angioplasty[J]. N Engl J Med, 2001, 344:243-249.
[10] Waksman R, Robinson KA, Crocker IR, et al. Intracoronary low-dose beta-irradiation inhibits neointima formation after coronary artery balloon injury in the swine restenosis model[J]. Circulation, 1995, 92:3025-3031.
[11] Mitchell JB. Radiation biology concepts for the use of radiation to prevent restenosis[A]. Waksman Red.Vascular Brachtherapy[C]. Second Edition, New York:Futura Publishing Co Inc, 1999. 268.
[12] Waksman R, Robinson KA, Crocker IR, et al. Endovascular low-dose irradiation inhibits neointima formation after coronary artery balloon injury in swine[J]. Circulation, 1995, 91(5):1533-1539.
[13] Abbas MA, Afshari NA, Stadius ML, et al. External beam irrdiation inhibits neointimal hyperplasia following balloon angioplasty[J]. Int J Cardiol, 1994, 44:191-202.
[14] Wakesman R. Late thrombosis after radiation[J].Circulation, 1999, 100:780-782.
[15] Costa MA, Sabat M, van-der-Giessen WJ, et al. Late coronary occlusion after intracoronary brachytherapy[J]. Circulation, 1999, 100(8):789-792.
[16] Martin B L. Localized intracoronary γ-radiation therapy to inhibit the recurrence of restenosis after stenting[J]. N Engl J Med, 2001, 344:250-256.
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备注/Memo

备注/Memo:
收稿日期:2001/8/3。
基金项目:国家自然基金资助项目(39900167)
作者简介:庄永志(1972-),男,黑龙江大庆人,大庆油田总医院主治医师,现为北京大学第三医院肿瘤治疗中心硕士研究生,主要从事射线抑制再狭窄的细胞和分子生物学机制研究;王俊杰(1964-),男,内蒙古乌兰浩特人,北京大学第三医院肿瘤治疗中心副主任医师,硕士,主要从事射线抑制再狭窄的细胞和分子生物学机制及肿瘤粒子种植治疗的研究。
更新日期/Last Update: 1900-01-01