[1]陈建伟.电离辐射对血管内皮细胞影响的研究[J].国际放射医学核医学杂志,2001,25(1):33-37.
 CHEN Jian-wei.The study of the effect of ionizing radiation on vascular endothelial cells[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(1):33-37.
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电离辐射对血管内皮细胞影响的研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第1期
页码:
33-37
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
The study of the effect of ionizing radiation on vascular endothelial cells
作者:
陈建伟
200001 上海, 上海第二医科大学附属仁济医院核医学科
Author(s):
CHEN Jian-wei
Renji hospital, Shanghai second medical university, Shanghai 200001, China
关键词:
电离辐射内皮细胞再狭窄
Keywords:
ionizing radiationendothelial cellsrestenosis
分类号:
Q274
摘要:
利用放射性核素血管内照射治疗血管再狭窄逐渐受重视,但其作用机制未完全清楚。血管再狭窄是动脉损伤后的愈合反应,内皮细胞参与愈合过程。血管内皮损伤作为血管再狭窄的始动因素,内皮细胞的增殖与凋亡影响和干预再狭窄的过程。电离辐射影响血管内皮细胞的存活、凋亡、增殖、表型、功能等。通过电离辐射对血管内皮细胞影响的研究将有助于再狭窄的防治。
Abstract:
The treatment of vessel restenosis by endovascular radiation is being taken into account. However, the mechanism for prevention of restenosis is not clear. Restenosis is a complex process that comprises endothelial cells and others. It appears, fundamentally, to be a wound-healing process. The injury of vascular endothelium is initial influence on the development ofrestenosis. The proliferation and apoptosis of endothelial cells will effect and intervene in the course of restenosis. Ionizing radiation will influence survival, apoptosis, proliferation, phenotype and function for endothelial cells. It will contribute the prevention of restenosis by means of the study of the effect of ionizing radiation on vascular endothelial cells.

参考文献/References:

[1] Fischell TA,Kharma BK,Fischell DR,et al.Low-dose,β-particle emission from ‘stent’ wire results incomplete localized inhibition of smooth muscle cell proliferation[J].Circulation,1994,90:2956-2963.
[2] Vodovotz Y,Wakesman R,Kim W H,et al.Effects of intracoronary radiation on thrombosis after balloon overstretch injury in the porcine model[J].Circula-tion,1999,100:2527-2533.
[3] Warden AJ,Mbchb IP,Sabate M,et al.β-particle emis-sion radioactive stent implantation[J].Circulation,1999,100:1684-1689.
[4] King SB,Williums DO,Chougule P,et al.Endovascular β-radiotion to reduce restenosis after coronary balloon angioplasty[J].Circulation,1998,97:2025-2030.
[5] Waksman R,Robinson KA,Crocker IR,et al.En-dovascular low-dose irradiation inhibits neointima for-mation after coronary artery balloon injury in swine[J].Circulation,1995,91,1533-1539.
[6] Costa M,Sabate M,van Der-Giessen W J,et al.Latte coronary occlusion after intracoronary brachytherapy[J].Circulation,1999,100:789-792.
[7] Schulz C,Niederer C,Andres C,et al.Endovascular ir-radiation from beta-particle-emitting gold stents re-sults in increased neointima formation in a porcine restenosis model[J].Circulation,2000,101(16):1970-1975.
[8] Verin,Poppwski Y,Urban P,et al.Intra-arteral beta ir-radiation prevents neointimal hyperplasia in a hyperc-holesterolemic rabbit restenosis model[J].Circulation,1995,92:2284-2290.
[9] Rose RW,O’ Hara M,Williamson SK,et al.The role of laminin-1 in the modulation of radiation damage in endothelial cells and differentiation[J].Radiat Res,1999,152:14-28.
[10] Meerlin D,Tardif JC,Crocker IR,et al.Effects of in-tracoronary β-radiation therapy after coronary angio-plasty[J].Circulation,1999,99:1660-1665.
[11] O’Connor MM,Mayberg M R.Effects of radiation on cerebral vasculature:a review[J].Neurosurgery,2000,46:138-151
[12] Grafe M,Steinheider G,Desaga U,et al.Characteriza-tion of two distinct mechanisms for induction of apop-tosis in human vascular endothelial cells[J].Clin Chem Lab Med,1999,37(5):505-510.
[13] Fareh J,Martel R,Kermani P,et al.Cellular effects of β-particle delivery on vascular smooth muscle cells and endothelial cells[J].Circulation,1999,99:1477-1484.
[14] Albiero R,Adamian M,Kobayashi N,et al.Short-and intermediate-term result of (32) P radioactive beta-emitting stent implantation in patients with coronary artery disease:The Milan dose-response study[J].Circulation,2000,101(1):18-26.
[15] Plasswilm L,Hoper J,Cordes N,et al.Investigation of microvessel density after irradiation[J].Radiat Res,1999,151(4):454-460.
[16] Hallahan DE,Virudachalam S.Accumulation of P-se-lectin in the lumen of irradiated blood vessels[J].Radi-at Res,1999,152(1):6-13.
[17] Gaugler M H,Squiban C,Van A,et al.Late and persis-tent up-regulation of intercellular adhesion molecule-1(ICAM-1) expression by ionizing radiation in human endothelial cells in vitro[J].Int J Radiat Biol,1997,72(2):201-209.
[18] Jahroudi N,Ardekani AM,Greenberger JS.Ionizing irradiation increases transcription of the von Wille-brand factor gene in endothelial cells[J].Blood,1996,88(10):3801-3814.
[19] Katoh O,Tauchi H,Kawaishi K,et al.Expression of the vascular endothelial growth factor (V EGF) receptor gene,KDR,in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing ra-diation[J].Cancer Res,1995,55:5687-5692.
[20] Gorski DH,Beckett M A,Jaskoowiak N T,et al.Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ioniz-ing radiation[J].Cancer Res,1999,59(14):3374.
[21] Morishita R,Aoki M,Nakarnura S,et al.Potential role of a novel vascular modulator,hepatocyte growth factor (HGF),incardiovascular disease:characteriza-tion and regulation of local HGF system[J].J Ather Thrombo,1997,4(1):12-19.
[22] Langey RE,Bump EA,Quartuccio SG,et al.Radia-tion-induced apoptosis in microvascular endothelial[J].Br J Cancer,1997,75(5):666-672.
[23] Petrova TV,Makinen T,Alitalo K.Signaling via vas-cular endothelial growth factor receptors[J].Exp Cell Res,1999,253:117-130.
[24] Sabate M,Kay IP,van-Der-Giessen W J,et al.Perserved endotheliumdependent vasodilation in coro-nary segments previously treated with balloon angio-plasty and intracoronary irradiation[J].Circulation,1999,100(15):1623-1629.
[25] Gorski DH,Beckett M A,Jaskowiak N T.Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation[J].Cancer Res,1999,59(14):3374-3378.
[26] Bauters C,Six I,Meurice T,et al.Growth factors and endothelilal dysfunction[J].Drugs,1999,59:11-15.

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备注/Memo

备注/Memo:
收稿日期:2000/11/6。
作者简介:陈建伟(1970-),男,江苏武进人,上海第二医科大学附属仁济医院核医学科医师,硕士研究生,主要从事放射性核素抑制血管再狭窄的研究。
更新日期/Last Update: 1900-01-01