[1]何淑杰,刘树铮.NF-κB不同二聚体的活化与辐射诱导凋亡的关系[J].国际放射医学核医学杂志,2001,25(2):74-77.
 HE Shu-jie,LIU Shu-zheng.The relation between activation of different dimers of NF-κB and radiation-induced apoptosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(2):74-77.
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NF-κB不同二聚体的活化与辐射诱导凋亡的关系(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第2期
页码:
74-77
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
The relation between activation of different dimers of NF-κB and radiation-induced apoptosis
作者:
何淑杰 刘树铮
130021 长春, 卫生部放射生物学重点实验室
Author(s):
HE Shu-jie LIU Shu-zheng
Radiobiology Research Unit, Ministry of Health, PRC, Changchun 130021, China
关键词:
NF-κB辐射细胞凋亡
Keywords:
NF-κBradiationapoptosis
分类号:
R818.03
摘要:
转录因子κ基因结合核因子(NF-κB)一直被看作是细胞的存活因子,对辐射诱导的细胞凋亡起强烈的抵抗作用。然而,近来的研究逐渐表明,NF-κB不同亚基的组合可能有着不同、甚至完全相反的作用。对这方面课题的深入研究,无疑对理解中、高剂量辐射免疫抑制效应的机制可提供有意义的理论依据,并对临床肿瘤的放疗将提供新的有价值的资料。
Abstract:
NF-κB used to be considered as a surviving factor, conferring vigorous resistance to cells against radiation-induced apoptosis. However, recent research gradually disclosed that combination of different subunits of NF-κB may have different, even opposite effects. Further investigation in more depth would undoubtedly provide theoretical basis for the understanding of the mechanism of the depressive effect of medium to high doses of radiation on immunity and valuable new information for radiotherapy of clinical tumors.

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备注/Memo

备注/Memo:
收稿日期:2000/12/5。
作者简介:何淑杰(1967-),女,吉林农安人,白求恩医科大学放射生物室博士,现在新西兰做博士后研究工作。;刘树铮(1925-),男,湖南长沙人,白求恩医科大学卫生部放射生物重点实验室教授,博士生导师,主要从事低水平辐射生物效应研究。
更新日期/Last Update: 1900-01-01