[1]闫玉军,叶翔,宋娜玲,等.DHEA对放、化疗损伤造血功能保护作用的实验研究[J].国际放射医学核医学杂志,2014,38(3):164-166,178.[doi:10.3760/cma.j.issn.1673-4114.2014.03.006]
　Yan Yujun,Ye Xiang,Song Naling,et al.Study on the protective function of DHEA on hematopoietic induced by radiotherapy and chemotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):164-166,178.[doi:10.3760/cma.j.issn.1673-4114.2014.03.006]
点击复制

DHEA对放、化疗损伤造血功能保护作用的实验研究(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第3期
页码:
164-166,178
栏目:
出版日期:
2014-05-25

文章信息/Info

Title:
Study on the protective function of DHEA on hematopoietic induced by radiotherapy and chemotherapy
作者:
闫玉军1;  叶翔2;  宋娜玲1;  王月英1;  李德冠1;  路璐1;  孟爱民1;  吴红英1
1. 300192 天津, 中国医学科学院放射医学研究所, 天津市放射医学与分子核医学重点实验室;
2. 300384 天津, 天津迈达医学科技有限公司
Author(s):
Yan Yujun1;  Ye Xiang2;  Song Naling1;  Wang Yueying1;  Li Deguan1;  Lu Lu1;  Meng Aimin1;  Wu Hongying1
Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China
关键词:
γ射线; 环磷酰胺; 造血功能; 17aα-D-高炔雌二醇-3-乙酯
Keywords:
Gama rays; Cyclophosphamide; Hematopoietic function; Dehydroepiandrosterone
DOI:
10.3760/cma.j.issn.1673-4114.2014.03.006
摘要:
目的 研究17aα-D-高炔雌二醇-3-乙酯(DHEA)对137Cs γ射线和环磷酰胺(CTX)所致小鼠造血及免疫功能损伤的保护作用。方法 分别用8.0 Gy 137Cs γ射线和CTX建立C57BL/6小鼠动物模型,观察DHEA低、中、高3个剂量对两个模型小鼠的造血干细胞脾结节形成细胞(CFU-S)数、外周血WBC、骨髓有核细胞数、脾脏指数的影响。结果 DHEA各组对小鼠137Cs γ射线照射所致的外周血WBC、CFU-S数、骨髓有核细胞数的降低具有保护作用,并增大了脾脏指数。DHEA各组对环磷酰胺引起的小鼠WBC、CFU-S数、骨髓有核细胞数降低有抑制作用。结论 DHEA能减轻辐射和环磷酰胺对小鼠造血系统的损伤。
Abstract:
Objective To observe the protective function of dehydroepiandrosterone (DHEA) on hematopoietic in C57BL/6 mouse induced by radiotherapy and chemotherapy.Methods Constructing the animal models with hematopoietic injury by 8.0 Gy 137Cs γ ray and cyclophosphamide respectively.Observe the changes of colony-forming unit-spleen (CFU-S),populations of peripheral WBC and bone marrow nu-cleated cells and index of spleen in all DHEA treated groups.Results DHEA can reduce injury of 137Cs γ ray and cyclophosphamide induced hematopoietic function injury of C57BL/6 mouse.Compared with the blank control group,the DHEA group can significantly increase the number of peripheral blood leukocyte,bone marrow nucleated cells and CFU-S,and there is statistically difference between DHEA treated group and the blank control group.Index of spleen in the high dose group is higher than that in the blank control group.Conclusion DHEA have protection function on hematopoietic in C57BL/6 mouse induced by ra-diotherapy and chemotherapy.

参考文献/References:

[1] 王月英,王汝勤,赵忠萍.E838对小鼠辐射防护作用的观察[J].中华放射医学与防护杂志,2005,24(1):39-40.
[2] 中华人民共和国卫生部药政局.新药(西药)临床前研究指导原则汇编[M].北京:人民卫生出版社,1993:103.
[3] 李佳,王月英,邢志伟,等.角质细胞生长因子对受照小鼠的遗传保护作用[J].国际放射医学核医学杂志,2013,37(4):196-198,220.
[4] 徐冰心,肖成荣,郑思新,等.辐射防护剂研究进展[J].中华放射医学与防护杂志,2002,22(11):64-67.
[5] Henderson MA,Valluri S,Garrett J,et al.Effects of estrogen and gender on cataractogenesis induced by high-LET radiation[J].Ra-diat Res,2010,173(2):191-196.
[6] 李墨林,李传刚,舒晓宏,等.化疗治愈荷瘤小鼠模型的建立及氟尿嘧啶抑瘤作用的免疫机制[J].细胞与分子免疫学杂志,2007,23(11):1010-1013.
[7] 宋国丽,季百苗,张小云.旋转恒定磁场对化疗损伤小鼠造血功能保护作用的研究[J].中国康复理论与实践,2006,12(3):213-216.

相似文献/References:

[1]董娟聪,刘红艳,党旭红,等.12c重离子与γ射线对人外周血淋巴细胞peng-ebv增殖、细胞周期及凋亡影响的比较[J].国际放射医学核医学杂志,2015,39(5):385.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 007]
　dong juancong,liu hongyan,dang xuhong,et al.effects of 12c heavy ion and γ ray irradiation in cell growth, cell cycle and apoptosis of human peripheral blood lymphocytes[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):385.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 007]
[2]路璐,李德冠,张俊伶,等.RNA干扰沉默p16基因对小鼠胚胎成纤维细胞衰老的影响[J].国际放射医学核医学杂志,2014,38(5):281.[doi:10.3760/cma.j.issn.1673-4114.2014.05.001]
　Lu Lu,Li De-guan,Zhang Jun-ling,et al.Application of RNA interference vector targeting mouse p16 gene in γ-irradiation-induced mouse embryonic fibroblast[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):281.[doi:10.3760/cma.j.issn.1673-4114.2014.05.001]
[3]王月英,王小春,吴红英,等.17aα-D-高炔雌二醇-3-乙酯联合γ射线照射对不同品系小鼠的抑瘤作用[J].国际放射医学核医学杂志,2012,36(2):97.[doi:10.3760/cma.j.issn.1673-4114.2012.02.010]
　WANG Yue-ying,WANG Xiao-chun,WU Hong-ying,et al.Inhibitory effects of 17aα-D-homo ethynylestradiol-3-acetate combined with γ-ray irradiation on adenocarcinoma of the lung in different mice strains[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(3):97.[doi:10.3760/cma.j.issn.1673-4114.2012.02.010]
[4]李德冠,王月英,吴红英,等.大剂量γ射线照射对小鼠免疫系统损伤远期影响的研究[J].国际放射医学核医学杂志,2012,36(2):109.[doi:10.3760/cma.j.issn.1673-4114.2012.02.013]
　LI De-guan,WANG Yue-ying,WU Hong-ying,et al.The long-term effects of high γ-ray dose on the mice immune system[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(3):109.[doi:10.3760/cma.j.issn.1673-4114.2012.02.013]
[5]路璐,李德冠,王月英,等.脂多糖对受照小鼠血清IL-10、IL-6和TNF-α水平的影响[J].国际放射医学核医学杂志,2012,36(3):154.[doi:10.3760/cma.j.issn.1673-4114.2012.03.008]
　LU Lu,LI De-guan,WANG Yue-ying,et al.Effects of lipopolysaccharide on IL-10, IL-6 and TNF-α levels in radiation-exposed mice[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(3):154.[doi:10.3760/cma.j.issn.1673-4114.2012.03.008]
[6]夏璐,丘冠英,夏寿萱.辐射诱发突变热点研究进展[J].国际放射医学核医学杂志,1997,21(1):30.
[7]何淑雅,蒋雨薇,王五洲,等.不同剂量137Cs γ射线照射对雌果蝇的辐射损伤和氧化效应[J].国际放射医学核医学杂志,2018,(2):143.[doi:10.3760/cma.j.issn.1673-4114.2018.02.008]
　He Shuya,Jiang Yuwei,Wang Wuzhou,et al.Irradiation damage and oxidative effects of different doses by 137Cs gamma ray on female Drosophila melanogaster[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(3):143.[doi:10.3760/cma.j.issn.1673-4114.2018.02.008]
[8]孙晓辉,孔阳阳,路倩颖,等.肺癌细胞A549和H460对137Cs γ射线辐射敏感性差异的研究[J].国际放射医学核医学杂志,2018,(4):346.[doi:10.3760/cma.j.issn.1673-4114.2018.04.011]
　Sun Xiaohui,Kong Yangyang,Lu Qianying,et al.Difference of radiosensitivity for 137Cs γ-radiation between A549 and H460 lung cancer cell lines[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(3):346.[doi:10.3760/cma.j.issn.1673-4114.2018.04.011]

备注/Memo

备注/Memo:
收稿日期:2014-01-22。
基金项目:国家973重大专项(2011CB964800-G);国家自然科学基金(81072237,81372928);天津市重点基金(11JCZD-JC19100);中国医学科学院放射医学研究所发展基金(SF1104,SF0826,SF1419)
通讯作者:吴红英,Email:why999@irm-cams.ac.cn
更新日期/Last Update: 1900-01-01