[1]陈宁琳,鲍逸民,杨永青.血浆ATⅡ、NPY、IGF-1和hs-CRP水平测定在评估冠心病患者严重程度中的应用价值[J].国际放射医学核医学杂志,2014,38(3):167-170.[doi:10.3760/cma.j.issn.1673-4114.2014.03.007]
　Chen Ninglin,Bao Yimin,Yang Yongqing.The application value of plsama ATⅡ, NPY, IGF-1 and hs-CRP levels in evaluation of coronary heart disease severity[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):167-170.[doi:10.3760/cma.j.issn.1673-4114.2014.03.007]
点击复制

血浆ATⅡ、NPY、IGF-1和hs-CRP水平测定在评估冠心病患者严重程度中的应用价值(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第3期
页码:
167-170
栏目:
出版日期:
2014-05-25

文章信息/Info

Title:
The application value of plsama ATⅡ, NPY, IGF-1 and hs-CRP levels in evaluation of coronary heart disease severity
作者:
陈宁琳1;  鲍逸民1;  杨永青2
1. 215002 苏州, 南京医科大学附属苏州市立医院急诊科;
2. 215002 苏州, 南京医科大学附属苏州市立医院核医学科
Author(s):
Chen Ninglin1;  Bao Yimin1;  Yang Yongqing2
Department of Emergency, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou 215002, China
关键词:
冠心病; 血管紧张素Ⅱ; 神经肽Y; 胰岛素样生长因子-Ⅰ; 高敏C-反应蛋白; 放射免疫测定; 免疫酶技术
Keywords:
Coronary heart disease; AngiotensinⅡ; Neuropepti-de Y; Insulin-like growth factor Ⅰ; High sensitive C-reaction protein; Radioimmunoassay; Immunoenzyme techniques
DOI:
10.3760/cma.j.issn.1673-4114.2014.03.007
摘要:
目的 探讨血浆血管紧张素Ⅱ(ATⅡ)、神经肽Y (NPY)、胰岛素样生长因子1(IGF-1)和高敏C反应蛋白(hs-CRP)水平测定在评估冠心病患者严重程度中的应用价值。方法 采用放射免疫分析、酶免疫分析和高敏酶免疫分析法分别测定157例冠心病患者[包括51例稳定型心绞痛(SA)患者、45例不稳定型心绞痛(USA)患者和61例急性心肌梗死(AMI)患者]的血浆ATⅡ、NPY、IGF-1和hs-CRP水平,并与60名正常对照者进行对比分析。结果 157例CHD患者血浆ATⅡ水平与60名正常对照者相比,差异有统计学意义(tSA ATⅡ=2.257,P<0.05;tUSA ATⅡ=3.018,P<0.01;tAMI ATⅡ=4.143,P<0.001);血浆NPY水平较正常对照者增高(tSA NPY=1.413,P>0.05;tUSA NPY=2.148,P<0.05;tAMI NPY=3.068,P<0.01),但SA患者与正常对照者之间的差异无统计学意义;血浆IGF-1水平与正常对照者相比,差异有统计学意义(tSA IGF-1=2.121,P<0.05;tUSA IGF-1=2.937,P<0.01;tAMI IGF-1=4.217,P<0.001);血浆hs-CRP水平与正常对照者相比,差异有统计学意义(tSA hs-CRP=2.095,P<0.05;tUSA hs-CRP=2.867,P<0.01;tAMI hs-CRP=4.349,P<0.001)。血浆ATⅡ、NPY、IGF-1和hs-CRP水平随着SA、USA和AMI患者的严重程度而增高。结论 血浆ATⅡ、NPY、IGF-1和hs-CRP水平是判断冠心病患者严重程度的有价值指标,亦可以用于治疗后的随访。
Abstract:
Objective To explore the application value of angiotensin Ⅱ(ATⅡ),neuropeptide Y (NPY),insulin-like growth factor 1(IGF-1) and high sensitive C-reaction protein (hs-CRP) levels in e-valuation of the severity of coronary heart disease (CHD).Methods The plasma ATⅡ,NPY,IGF-1 and hs-CRP levels in 157 patients with CHD[including 51 cases with stable angina (SA),45 cases with unstable angina (USA) and 61 cases with acute myocardial infraction (AMI)]were measured by radioim-munoassay,enzyme immunoassay and high sensitive enzyme immunoassay and were compared with 60 health controls.Results The plasma ATⅡ level in 157 patients with CHD was significantly higher than those in 60 controls (tSA ATⅡ=2.257,P<0.05;tUSA ATⅡ=3.018,P<0.01;tAMI ATⅡ=4.143,P<0.001).The plasma NPY level in 157 patients with CHD was higher than those in 60 controls (tSA NPY=1.413,P>0.05;tUSA NPY=2.148,P<0.05;tAMI NPY=3.068,P<0.01),but there were no significant difference between SA pa-tients and the 60 conrols.The plasma IGF-1 level in 157 patients with CHD was significantly higher than those in 60 controls (tSA IGF-1=2.121,P<0.05;tUSA IGF-1=2.937,P<0.01;tAMI IGF-1=4.217,P<0.001).The plasma hs-CRP level in 157 patients with CHD was significantly higher than those in 60 controls (tSA hs-CRP=2.095,P<0.05;tUSA hs-CRP=2.867,P<0.01;tAMI hs-CRP=4.349,P<0.001).The four plasma biomarkers were increased with severity of CHD.Conclusion The plasma ATⅡ,NPY,IGF-1 and hs-CRP levels were valuable indexes for judging the severity of patients with CHD,and could be used for follow-up.

参考文献/References:

[1] Bauriedel G,Hutter R,Welsch U,et al.Role of smooth muscle cell death in advanced coronary primary lesions:implications for plaque instobility[J].Cardiovasc Res,1999,41(2):480-488.
[2] 苏应瑞,查金顺,许朝祥,等.阻塞性睡眠呼吸暂停低通气综合症伴冠心病:血清高半胱氨酸和C-反应蛋白水平及临床意义[J].国际放射医学核医学杂志,2011,35(5):275-278.
[3] Wu CK,Tseng CD,Huang YT,et al.AngiotensinⅡ does not influ-ence expression of sureplasmic reticulum Ca2+ ATpase in atrial my-ocytes[J].J Renin Angiotension Aldosterone Syst,2009,10(3):121-126.
[4] Ruster C,Wolf G.Renin-angiotension-aldosterone system and pro-gression of renal disease[J].J Am Soc Nephrol,2006,17(11):2985-2991.
[5] Zukowska Z,Granl DS,Lee FW.Neuropeptide Y:a noval mecha-nism for ischemic angioenesis[J].Trends Cardiovasc Med,2003,13(2):86-92.
[6] Ekstrand AJ,Gao R,Bjorndahl M,et al.Deletion of neuropeptide Y (NPY)2 receptor in mice results in blockage of NPY-induced an-giogenesis and delayed wound healing[J].Proc Natl Acad Sci USA,2003,100(10):6033-6042.
[7] 陆永怡,陈群,杨永青.原发性高血压、AngⅡ分型和IGF-1水平的测定[J].国际放射医学核医学杂志,2010,34(5):294-296.
[8] Monteiro CM,Pinheiro LF,Izar MC,et al.Highly sensitive C-reac-tive protein and male gender are independently related to the severity of coronary disease in patients with metabolic syndrome and a acute coronary event[J].Braz J Med Biol Res,2010,43(3):297-302.
[9] Nishida H,Horio T,Suzuki Y,et al.Interleukin-6 as an indepen-dent predictor of future cardiovascular events in high-risk Japanese patients:comparison with C-reactive protein[J].Cytokine,2011,53(3):342-346.

相似文献/References:

[1]薛倩倩,姚稚明.冠状动脉钙化积分、心肌灌注显像及其联合应用的临床价值[J].国际放射医学核医学杂志,2013,37(5):301.[doi:10.3760/cma.j.issn.1673-4114.2013.05.012]
　XUE Qian-qian,YAO Zhi-ming.The clinic application of coronary artery calcification scores and myocardial perfusion imaging and the combination[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(3):301.[doi:10.3760/cma.j.issn.1673-4114.2013.05.012]
[2]刘清权,查金顺,王耀国,等.甲状腺功能与冠脉病变程度的相关性研究[J].国际放射医学核医学杂志,2013,37(6):340.[doi:10.3760/cma.j.issn.1673-4114.2013.06.004]
　LIU Qing-quan,ZHA Jin-shun,WANG Yao-guo,et al.Correlation between thyroid function and the severity of coronary artery disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(3):340.[doi:10.3760/cma.j.issn.1673-4114.2013.06.004]
[3]陆永怡,陈群,杨永青.原发性高血压PRA、AngⅡ分型和IGF-1水平的测定[J].国际放射医学核医学杂志,2010,34(5):294.[doi:10.3760/cma.j.issn.1673-4114.2010.05.011]
　LU Yong-yi,CHEN Qun,YANG Yong-qing.Application of determination of PRA, Ang Ⅱ and IGF-1 levels in the study of typing of essential hypertension[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(3):294.[doi:10.3760/cma.j.issn.1673-4114.2010.05.011]
[4]苏应瑞,查金顺,许朝祥,等.阻塞性睡眠呼吸暂停低通气综合征伴冠心病:血清高半胱氨酸和C-反应蛋白水平及临床意义[J].国际放射医学核医学杂志,2011,35(5):275.[doi:10.3760/cma.j.issn.1673-4114.2011.05.005]
　SU Ying-rui,ZHA Jin-shun,XU Chao-xiang,et al.Evaluation and clinical significance of serum C-reactive protein and homocysteine level in obstructive sleep apnea/hypopnea syndrome complicated with coronary heart disease patients[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(3):275.[doi:10.3760/cma.j.issn.1673-4114.2011.05.005]
[5]刘义明,揭育丽.充血性心力衰竭患者肾上腺髓质素与内皮素、血管紧张素Ⅱ结果比较[J].国际放射医学核医学杂志,2007,31(2):96.
　LIU Yi-ming,JIE Yu-li.A comparision between adrenomedullin, endothelin and angiotensin Ⅱ in patients with congestive heart failure[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(3):96.
[6]蔡迅,黄成文,黄仲良.连续性血液净化治疗顽固性心力衰竭患者35例结果分析[J].国际放射医学核医学杂志,2006,30(5):293.
　CAI Xun,HUANG Cheng-wen,HUANG Zhong-liang.Analyse in the patients with refractory heart purification treated by continuous blood purification[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(3):293.
[7]杨斌,李殿富.存活心肌判断中存在的问题及其原因[J].国际放射医学核医学杂志,2006,30(1):21.
　YANG Bin,LI Dian-fu.The problems and the causes in viable myocardial detection[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(3):21.
[8]张佳胤.核素心肌显像在冠状动脉旁路移植术中的应用[J].国际放射医学核医学杂志,2005,29(4):152.
　ZHANG Jia-yin.Application of nuclear myocardial imaging in coronary artery bypass graft[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(3):152.
[9]王勤奋.心肌活力测定的研究进展[J].国际放射医学核医学杂志,2005,29(4):155.
　WANG Qin-fen.The progress of research on the assessment of viable myocardium[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(3):155.
[10]李殿富.核素心肌显像在冠心病处理决策中的合理应用及其原理[J].国际放射医学核医学杂志,2004,28(2):56.
　LI Dian-fu.The appropreciate use and the principles of myocardial perfusion imaging in the management of coronary artery disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(3):56.

备注/Memo

备注/Memo:
收稿日期:2013-05-21。
通讯作者:杨永青,Email:yangyongqing2009@163.com
更新日期/Last Update: 1900-01-01