[1]陆永怡,陈群,杨永青.原发性高血压PRA、AngⅡ分型和IGF-1水平的测定[J].国际放射医学核医学杂志,2010,34(5):294-296.[doi:10.3760/cma.j.issn.1673-4114.2010.05.011]
　LU Yong-yi,CHEN Qun,YANG Yong-qing.Application of determination of PRA, Ang Ⅱ and IGF-1 levels in the study of typing of essential hypertension[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(5):294-296.[doi:10.3760/cma.j.issn.1673-4114.2010.05.011]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第5期
页码:
294-296
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Application of determination of PRA, Ang Ⅱ and IGF-1 levels in the study of typing of essential hypertension
作者:
陆永怡1;  陈群1;  杨永青2
1. 215002, 苏州, 南京医科大学附属苏州医院心内科;
2. 215002, 苏州, 南京医科大学附属苏州医院核医学科
Author(s):
LU Yong-yi1;  CHEN Qun1;  YANG Yong-qing2
Department of Cardiovascular, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou 215002, China
关键词:
肾素; 血管紧张素Ⅱ; 胰岛素样生长因子Ⅰ; 高血压; 放射免疫测定; 免疫酶技术
Keywords:
Renin; Angiotensin Ⅱ; Insulin-like growth factor Ⅰ; Hypertension; Radioimmunoassay
DOI:
10.3760/cma.j.issn.1673-4114.2010.05.011
摘要:
目的 研究原发性高血压(EH)血浆肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)分型和胰岛素样生长因子1(IGF-1)水平测定的临床意义。方法 用放射免疫法分析256例EH患者和70名正常对照者PRA和AngⅡ水平,酶免疫法分析IGF-1水平,并进行EH分型和组间对比的研究。结果 正常对照组PRA为(0.432±0.236)μg·L-1·h-1,AngⅡ为(31.7±7.4)μg/L。256例EH患者按PRA水平分型:增高者占18.0%,正常者占71.8%和降低者占10.2%;按AngⅡ水平分型:增高者占12.9%,正常者占76.2%和降低者占10.9%;血浆IGF-1水平随EH患者的血压水平升高而增高。结论 EH按PRA和AngⅡ水平分型以及对EH患者进行IGF-1水平的测定,有助于EH患者的治疗和随访。
Abstract:
Objective To study the clinical application of determination of plasma renin activity (PRA),Angiotensin Ⅱ (Ang Ⅱ) and insulin-like growth factor-1 (IGF-1) levels in typing of essential hypertension(EH).Methods Determined the levels of PRA and Aug Ⅱ in 256 patients with EH and 70 healthy volunteers (as control group) by radioimmunoassay, and measured IGF-1 level by enzyme immunoassay. Research on the typing of EH and the difference between the groups. Results The PRA and Ang Ⅱ in control group was (0.432±0.236) μg·L-1·h-1 and (31.7±7.4) μg/L respectively. In 256 patients with EH,PRA was increased, normal and decreased in 18.0%, 71.8% and 10.2% respectively, while the level of Ang Ⅱ was increased, normal and decreased in 12.9%, 76.2% and 10.9% respectively. The IGF-1 levels in 256 patients with EH were increased following the increase of blood pressure. Conclusion Typing of EH patients with PRA and Ang Ⅱ as well as the determination of IGF-1 were useful in treating and following up the patients with EH.

参考文献/References:

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[3] Leri A, Liu Y, Claudio PP, et al. Insulin-like growth factor-1 induces Mdm2 and down-requlates p53, attenuating the myoeyte rennin-angiotensin system and stretch-mediated apoptosis. Am J Pathol, 1999, 154(2):567-580.
[4] 中国高血压防治指南修订委员会.中国高血压防治指南(2005年修改版).北京:人民卫生出版社,2006.
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[6] 潘丽丽,王瑞英,朱国斌,等.血清胰岛素样生长因子-1与原发性高血压患者左心室肥厚和蛋白尿的关系.中国心血管杂志,2007,12(4):271-273.
[7] Onder G, Liperoti R, Russo A, et al. Use of ACE inhibitors is associated with elevated levels of IGFBP-3 aruong hypertensive older adults:results from the IISIRENTE study. Eur J Clin pharmacol, 2007, 63(4):389-395.

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备注/Memo

备注/Memo:
收稿日期:2010-06-02。
通讯作者:杨永青,E-mail:liyunweng@126.com
更新日期/Last Update: 1900-01-01