[1]习忻,刘韩英,徐先早,等.五鹤续断对辐射损伤小鼠保护作用的研究[J].国际放射医学核医学杂志,2010,34(2):116-119.[doi:10.3760/cma.j.issn.1673-4114.2010.02.016]
 XI Xin,LIU Han-ying,XU Xian-zao,et al.Study on radioprotective effect of Wu-He Dipsacus asper in mice[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(2):116-119.[doi:10.3760/cma.j.issn.1673-4114.2010.02.016]
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五鹤续断对辐射损伤小鼠保护作用的研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第2期
页码:
116-119
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
Study on radioprotective effect of Wu-He Dipsacus asper in mice
作者:
习忻 刘韩英 徐先早 朱继华
湖北省恩施州中心医院核医学科, 445000
Author(s):
XI Xin LIU Han-ying XU Xian-zao ZHU Ji-hua
Department of Nuclear Medicine, Central Hospital of Enshi Autonomous Prefecture of Hubei Province, Enshi 445000, China
关键词:
辐射损伤辐射防护五鹤续断
Keywords:
Radiation injuriesRadiation protectionWu-He Dipsacus asper
DOI:
10.3760/cma.j.issn.1673-4114.2010.02.016
摘要:
目的 研究五鹤续断(WHDA)注射液对辐射损伤小鼠的保护作用。方法 将160只昆明种雌性小鼠分为正常对照组、照射组和低剂量WHDA+照射组、高剂量WHDA+照射组,观察其30 d存活率;测定辐射后6 h、3 d、6 d、9 d小鼠的外周血象;测定辐射后小鼠的胸腺、脾脏和肝脏质量;测定辐射后小鼠外周血和肝脏的超氧化物歧化酶(SOD)、谷胱甘肽(GSH)及丙二酰二醛(MDA)水平。结果 WHDA可提高辐射后小鼠的存活率,对其白细胞及血小板的数量变化有显着影响,但对其胸腺、脾脏、肝脏质量均无明显影响。WHDA还能显着提高辐射后小鼠的SOD活性,增加GSH水平,降低MDA水平。结论 WHDA对辐射损伤小鼠有明显的保护作用。
Abstract:
Objective To study protective effect of Wu-He Dipsacus asper(WHDA) injection on the radiation damaged mice. Methods One hundred and twenty Kunming female mice were divided into normal control group, model control group, Wu-He Dipsacus asper treatment group to observe the 30-day survival rate;measured peripheral blood 6 hours, 3 days, 6 days and 9 days after irradiation, respectively; thymus, spleen and liver weight were detected; superoxide dismutase(SOD), glutathione(GSH), malonyldialdehyde(MDA) in liver and peripheral blood were also detected. Results W H D A can improve the survival rate of mice after radiation, and take a significant influence on white blood cells and platelets, but no obvious effect on the weight of thymus, spleen and liver. In addition, WHDA can improve SOD activity, increased GSH content and decrease M D A content significantly in this study. Conclusion WHDA has obvious protective effect in mice with radiation injury.

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备注/Memo

备注/Memo:
收稿日期:2009-12-09。
通讯作者:习忻(E-mail:xixinzz@l26.com)
更新日期/Last Update: 1900-01-01