[1]姚立新,付占昭,顾涛,等.99Tcm-甲氧基异丁基异腈SPECT评价非小细胞肺癌化疗疗效[J].国际放射医学核医学杂志,2009,33(5):272-274.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.005]
　YAO Li-xin,FU Zhan-zhao,GU Tao,et al.99Tcm-methoxyisobutylisonitrile SPECT imaging evaluate chemotherapy of non-small cell lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(5):272-274.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.005]
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99Tcm-甲氧基异丁基异腈SPECT评价非小细胞肺癌化疗疗效(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第5期
页码:
272-274
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
99Tcm-methoxyisobutylisonitrile SPECT imaging evaluate chemotherapy of non-small cell lung cancer
作者:
姚立新1;  付占昭2;  顾涛2;  郭雷鸣1;  华海侠2;  张庆怀2
1. 秦皇岛市第一医院核医学科, 秦皇岛 066000;
2. 秦皇岛市第一医院肿瘤科, 秦皇岛 066000
Author(s):
YAO Li-xin1;  FU Zhan-zhao2;  GU Tao2;  GUO Lei-ming1;  HUA Hai-xia2;  ZHANG Qing-huai2
1. Department of Nuclear Medicine, The First Hospital of Qinhuangdoo, Qinhuangdao 066000, China;
2. Department of Ontology, The First Hospital of Qinhuangdoo, Qinhuangdao 066000, China
关键词:
癌; 非小细胞肺; 99m锝-甲氧基异丁基异腈; 体层摄影术; 发射型计算机; 单光子; 药物疗法
Keywords:
Carcinoma; non-small cell lung; Technetium Tc99m sestamibi; Tomography; emission-computed; single-photon; Drug therapy
DOI:
10.3760/cnla.j.issn.1673-4114.2009.05.005
摘要:
目的 探讨99Tcm-氧基异丁基异腈(99Tcm-MIBI)SPECT评估非小细胞肺癌(NSCLC)化疗疗效的价值。方法 71例NSCLC患者根据胸部CT分为化疗有效组(完全缓解+部分缓解)和无效组(病情稳定+疾病进展),于化疗前行99Tcm-MIBI SPECT,静脉注射99Tcm-MIBI 740 MBq后10~30 min及2~3 h分别行早期及延迟显像,在99Tcm-MIBI显像图上用感兴趣区(ROI)的方法勾画出病灶,然后选取镜像ROI于健侧肺的相应部位,由此分别获得早期相肿瘤,正常肺组织摄取比值(ER)和延迟相肿瘤/正常肺摄取比值(DR),并计算滞留指数(RI)。采用t检验及秩和检验分析化疗有效组与化疗无效组ER、DR和RI之间的差别。结果 99Tcm-MIBI显像结果中,化疗有效组的ER、DR分别为2.39±0.21、2.50±0.19,均显著高于化疗无效组的1.89±0.19、2.05±0.21,统计学差异有意义(t=8.311、8.480,P<0.05)。化疗有效组的RI中位值为6.63%,高于化疗无效组的5.13%,统计学差异有意义(Z=2.416,P<0.05)。结论 99Tcm-MIBI显像在评估NSCLC化疗疗效方面具有重要的临床价值。
Abstract:
Objective To discuss 99Tcm-methoxyisobutylisonitrile(99Tcm-MIBI)imaging evaluation of the value of chemotherapy in patients with non-small cell lung cancer(NSCLC).Methods Seventy-one patients with NSCLC were studied with 99Tcm-MIBI SPECT before chemotherapy.The patients were classified by a follow-up CT as good responders(complete or partial remission)and poor respenders(stable disease or progressive disease).Following injection vein administration of 740MBq 99Tcm-MIBI,SPECT imaging at 10-30 min(early)and 2-3 h(delayed)were performed.Regions of interests were placed over the tumors and contralateral normal tissue on one transverse section.The 99Tcm-MIBI uptake ratio of the lesion to that in the contralateral normal lung was obtained from early images(ER)as well as delayed images(DR).The retention index(RI)was measured as:RI=(DR-ER)/ER×100%. 99Tcm-MIBI tumor uptake parameters were compared with the chemotherapeutic response.Results 99Tcm-MIBI uptake was significantly higher in responders than in non-responders:2.39±0.21 vs 1.89±0.19 and 2.50±0.19 vs 2.05±0.21 for ER and DR,respectively(t=8.311,8.480,P<0.05).The median of RI in good response group was significantly higher than that in poor response group(6.63% vs 5.13%,Z=2.416,P<0.05).Conclusion ER,DR and RI of 99Tcm-MIBI SPECT may benefit to evaluating chemotherapy response NSCLC.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2009-04-25。
通讯作者:姚立新(E-mail:yaolixin158@sina.com)
更新日期/Last Update: 1900-01-01