[1]戈畅,梁硕.化疗联合DC-CIK生物治疗非小细胞肺癌的临床价值及CT灌注成像的疗效评价[J].国际放射医学核医学杂志,2014,38(6):377-380,391.[doi:10.3760/cma.j.issn.1673-4114.2014.06.007]
　Ge Chang,Liang Shuo.The clinical value and CT perfusion evaluation in chemotherapy combined with DC-CIK biological treatment of non-small cell lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(6):377-380,391.[doi:10.3760/cma.j.issn.1673-4114.2014.06.007]
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化疗联合DC-CIK生物治疗非小细胞肺癌的临床价值及CT灌注成像的疗效评价(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第6期
页码:
377-380,391
栏目:
出版日期:
2014-11-25

文章信息/Info

Title:
The clinical value and CT perfusion evaluation in chemotherapy combined with DC-CIK biological treatment of non-small cell lung cancer
作者:
戈畅1;  梁硕2
1. 天津市人民医院干部保健科, 300121;
2. 天津市胸科医院影像科, 300222
Author(s):
Ge Chang1;  Liang Shuo2
Department of Cadre Health Care, People’s Hospital of Tianjin, Tianjin 300121, China
关键词:
癌; 非小细胞肺; 生物疗法; 药物疗法; CT灌注成像; 疗效评价
Keywords:
Carcinoma; non-small-cell lung; Biological therapy; Drug therapy; CT perfusion imaging; Evaluation
DOI:
10.3760/cma.j.issn.1673-4114.2014.06.007
摘要:
目的 探讨化疗联合树突状细胞-细胞因子诱导的杀伤细胞(DC-CIK)生物治疗在非小细胞肺癌(NSCLC)中的治疗价值,并且通过多层CT肺灌注成像的方法评价治疗效果的可行性。方法 选取经确诊的NSCLC患者30例(男性15例、女性15例),平均年龄(70.5±2.1)岁,将患者按照随机数字表分成对照组(n=15)和治疗组(n=15).对照组选用奥沙利铂+多烯紫杉醇的化疗方案,治疗组在此基础上增加DC-CIK生物治疗,两组治疗前、后均进行多层螺旋CT肺灌注成像。比较两组的临床治疗有效率(RR)和临床获益率(CBR),比较两组治疗前、后的CT灌注指标,包括血流量(BF)、血容量(BV)、表面通透性(PS)、达峰时间(TP)和平均通过时间(MTT).结果 对照组和治疗组的总RR为70.0%,总CBR为96.7%.其中,对照组的RR为46.7%、CBR为93.3%;治疗组的RR为93.3%、CBR为100%.在RR方面,治疗组与对照组相比差异有统计学意义(χ2=9.210,P<0.05).对照组治疗后的CT灌注指标较治疗前变化不具有统计学意义,治疗组治疗后的CT灌注指标较治疗前差异有统计学意义,表现为BF、BV、PS、TP均减低,MTT延长,治疗组的CT灌注指标与对照组比较差异有统计学意义。结论 联合DC-CIK治疗NSCLC比单纯化疗可以显着提高RR和CBR,并且多层螺旋CT灌注成像可以有效评价治疗效果。
Abstract:
Objective To evaluate the value of chemotherapy combined with dendritic cell-cytokine induced killer (DC-CIK)bio-treatment in the treatmeat of non-small cell lung cancer (NSCLC)and to estimate the therapeutic results by multislice spiral CT lung perfusion.Methods 30 cases of NSCLC patients who aged between 60 to 81 were collected,half male and half female,with an average age of 70.5 ±2.1.The patients were randomly divided into the treatment (n=15)and control groups (n=15).The control group was treated with oxaliplatin+docetaxel chemotherapy,and the treatment group increased DC-CIK biological treatment on this basis.Multislice spiral CT lung perfusion was performed in all of the patients before and after treatment.The clinical response rate (RR)and clinical benefit rate (CBR)were compared between the two groups,and the CT perfusion indices were compared before and after treatment,including blood flow (BF),blood volume (BV),permeability surface (PS),peak time (TP)and mean transit time (MTT).Results The total RR and CBR of the two groups were 70.0% and 96.7%.The RR and CBR in treatment group and control group were 46.7%,93.3% and 93.3%,100% respectively.Their differences had great statistical significance in RR between two groups (χ2=9.210,P<0.05).No significant difference could be observed on the CT perfusion indices before and after treatment in the control group.On the contrary,there were significant changes before and after treatment in the treatment group,which expressed as BF,BV,PS,TP were decreased and MTT was prolonged.There were significant differences between the two groups in CT perfusion indices after treatment.Conclusion Chemotherapy combined with DC-CIK treatment can significantly improve the RR and CBR of non-small cell lung cancer than chemotherapy alone,and multi-slice spiral CT perfusion can effectively evaluate the therapeutic effect.

参考文献/References:

[1] Rosenberg SA,Restifo NP,Yang JC,et al.Adoptive cell transfer:a clinical path to effective cancer immunotherapy[J].Nat Rev Cancer,2008,8(4):299-308.
[2] Sumpter K,Harper-Wynne C,Cunningham D,et al.Report of two protocol planned interim analyses in a randomised multicentre phase Ⅲ study comparing capeeitabine with fluomuracil and oxali-platin with cisplatin in patients with advanced oesophagogastric cancer receiving ECF[J].Br J Cancer,2005,92(11):1976-1983.
[3] Gao DQ,Li CY,Zhao P,et al.The clinical effects of dendritic cell and cytokine-induced killer cell therapy for lung cancer after surgery[J].Cancer Research,2014,74 Suppl 19:S2812.
[4] Zhang JP,Mao GH,Han YP,et al.The clinical effects of DC-CIK cells combined with chemotherapy in the treatment of advanced NSCLC[J].The Chinese German Journal of Clinical Oncology,2012,11(2):67-71.
[5] 王金万,孙燕,刘永煜,等.重组人血管内皮抑素联合NP方案治疗晚期NSCLC随机、双盲、对照、多中心Ⅲ期临床研究[J].中国肺癌杂志,2005,8(4):283-290.
[6] 赵利红,汪海岩,赵晶,等.DC-CIK细胞联合化疗治疗老年晚期非小细胞肺癌临床分析[J].徐州医学院学报,2013,33(12):880-883.
[7] 曾金武,冯茜茜.CIK细胞治疗晚期非小细胞肺癌50例临床观察[J].临床肺科杂志,2014,19(1):118-120.
[8] 张金娥,梁长弘,赵振军,等.CT肺灌注在肺结节诊断中的应用研究[J].中华放射学杂志,2005,39(10):.1041-1045.

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备注/Memo

备注/Memo:
收稿日期:2014-10-29。
通讯作者:梁硕(Email:movingspirit@163.com)
更新日期/Last Update: 1900-01-01