[1]郑磊,李前伟.18F-氟脱氧葡萄糖PET在原发陛肝细胞癌中的应用[J].国际放射医学核医学杂志,2008,32(1):23-26.
 ZHENG Lei,LI Qian-wei.Application of positron emission tomography with 18F-fluorodeoxyglucose in hepatocellular carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(1):23-26.
点击复制

18F-氟脱氧葡萄糖PET在原发陛肝细胞癌中的应用(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第1期
页码:
23-26
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Application of positron emission tomography with 18F-fluorodeoxyglucose in hepatocellular carcinoma
作者:
郑磊 李前伟
400038 重庆, 第三军医大学附属西南医院核医学科
Author(s):
ZHENG Lei LI Qian-wei
Department of Nuclear Medicine, Southwest Hospital of Third Military Medical University, Chongqing 400038, China
关键词:
肝细胞体层摄影术发射型计算机氟脱氧葡萄糖F18
Keywords:
CarcinomahepatocellularTomographyemission-computedFluorodeoxyglucose F18
分类号:
R817.4
摘要:
肝细胞癌(HCC)的早期诊断是获得临床治愈的关键,准确分期是制定合理治疗方案的基础。尽管18F-氟脱氧葡萄糖(18F-FDG)PET诊断HCC的总体敏感性不高,但其阳性显像与肿瘤分化程度、肝内外转移、门静脉癌栓及血清甲胎蛋白水平等许多因素相关。因此,18F-FDG PET在中、低分化的HCC诊断、分期与再分期、监测治疗反应、评价疗效、判断预后以及鉴别肝脏良性疾病等方面具有独特的价值。
Abstract:
Early diagnosis of hepatocellular carcinoma (HCC)is the key point for clinic healing, and accurate staging is the foundation of rational therapy. Positron emission tomography with 18F-fluorodeoxyglucose(18F-FDG) PET isn’t sufficiently sensitive on detecting HCC, hut the positive imaging is related on many factors such as malignant degree, intra/extrahepatic metastases, tumor thromhus in a portal vein, the level of alpha-fetoprotein in blood serum and so on. Thus, 18F-FDG PET has a special value on moderately or poorly differentiated HCC for differential diagnosing, staging and restaging, monitoring responses to treatments, evaluating therapeutic effects, and predicting the prognosis.

参考文献/References:

[1] Lee JD, Yang WI, Park YN, et al. Different glucose uptake and glycolytic mechanisms between hepatocellular carcinoma and intrahepatic mass-forming cholangiocarcinoma with increased 18F-FDG uptake[J]. J Nucl Med, 2005, 46(10):1753-1759.
[2] Yu Kuang, Schomisch SJ, Chandramouli V, et al. Hexokinase and glu-cose-6-phosphatase activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma[J]. Comp Biochem Physiol, C Toxicol Pharmacol, 2006, 143(2):225-231.
[3] Torizuka T, Tamaki N, Inokuma T, et al. In vivo assessment of glucose metabolism in hepatocellular carcinoma with FDG-PET[J]. J Nucl Med, 1995, 36(10):1811-1817.
[4] 李正平,周杰,张峻,等.18F-FDG PET在原发性肝癌中的诊断作用[J].肝胆外科杂志,2005,13(5):351-354.
[5] Seo S, Hatano E, Higashi T, et al. Fluorine-18 fluorodeoxyglucose positron emission tomography predicts tumor differentiation, Pglycoprotein expression, and outcome after resection in hepatocellular carcinoma[J]. Clin Cancer Res, 2007, 13(2Pt 1):427-433.
[6] Yang SH, Suh KS, Lee HW, et al. The role of 18F-FDG-PET imaging for the selection of liver transplavtation candidates from among hepatocellular carcinoma patients[J]. Transplantation, 2006, 82(1 Suppl 2):350.
[7] Iwata Y, Shiomi S, Sasaki N, et al. Clinical usefulness of positron emissiontomography with fluorine-18-fluorodeoxyglucose in the diagnosis of livertumors[J]. Ann Nucl Med, 2000, 14(2):121-126.
[8] Jeng LB, Changlai SP, Shen YY, et al. Limited value of 18F-2-deoxyglucose positron emission tomography to detect hepatocellular carcinoma in hepatitis B virus carriers[J]. Hepatogastroenterology, 2003, 50(54):2154-2156.
[9] Kurtaran A, Becherer A, Pfeffel F, et al. 18F-fluorodeoxyglucose (FDG)-PET features of focal nodular hyperplasia(FNH) of the liver[J]. Liver, 2000, 20(6):487-490.
[10] Sugiyama M, Sakahara H, Torizuka T, et al. 18F-FDG PET in the detection of extrahepatic metastases from hepatocellular carcinoma[J]. J Gastroenterol, 2004, 39(10):961-968.
[11] Kuker RA, Mesoloras G, Gulec SA. Optimization of FDG-PET/CT imaging protocol for evaluation of patients with primary and metastatic liver disease[J]. Int Semin Surg Oncol, 2007, 4:17.
[12] Wudel LJ, Delbeke D, Morris D, et al. The role of[18F] fluorodeoxyglucose positron emission tomography imaging in the evaluation of hepatocellular carcinoma[J]. Am Surg, 2003, 69(2):117-124.
[13] Lai P, Bomanji JB, Mahmood S, et al. Detection of tumour thrombus by 18F-FDG-PET/CT imaging[J]. Eur J Cancer Prey, 2007, 16(1):90-94.
[14] Ludwig V, Hopper OW, Martin WH, et al. 18F-Fluorodeoxyglucose positron emission tomography surveillance of hepatic metastases from prostate cancer following radiofrequency ablation; a case report[J]. Am Surg, 2003, 69(7):593-598.
[15] 赵明,吴沛宏,曾益新,等.18FDG-PET/CT对评价TACE联合RFA治疗原发性肝癌的效果的价值[J].癌症,2005,24(9):1118-1123.
[16] 谭志斌,赵明,吴沛宏,等.18F-FDG PET/CT在原发性肝癌介入治疗中的价值[J].介入放射学杂志,2005,14(6):588-591.
[17] Blokhuis TJ,Van Der Schoof MC,Van Den Tol MP, et al. Results of radio frequency ablation of primary and secondary liver tumors:Long-term follow-up with computed tomography and positron emission tomography-18F-deoxyfluoroglucose scanning. Scand J Gastroenterol Suppl, 2004, (241):93-97.
[18] 商健彪,李彦豪,刘方颖,等.18F-FDG PET显像在肝细胞癌介入治疗后残留病灶检出中的应用[J].中华核医学杂志,2004,24(6):325-327.
[19] Szyszko T, AF Nahhas A, Canelo R, et al. Assessment of response to treatment of unresectable liver tumours with 90Y microspheres:Value of FDG PET versus computed tomography[J]. Nucl Med Commun, 2007, 28(1):15-20.
[20] Wang XL, Li H, Wang QS, et al. Clinical value of pre-and postoperative 18F-FDG PET/CT in patients undergoing liver transplantatiOn for hepatocellular carcinoma[J]. J South Med Univ, 2006, 26(8):1087-1091.
[21] 蒋宁一,张弘,王捷,等.25例肝癌术后患者18F-FDG SPECT/CT同机融合显像分析[J].生物医学工程与临床,2004,8(2):100-102.
[22] Kong YH, Han CJ, Lee SD, et al. Positron emission tomography with fluorine-18-fluorodeoxyglucose is useful for predicting the prognosis of patients with hepatocellular carcinoma[J]. Korean J Hepatol, 2004, 10(4):279-287.

相似文献/References:

[1]李景涛,邓垒,张文珏,等.广泛期小细胞肺癌胸部IMRT后发生放射性肺炎的危险因素分析[J].国际放射医学核医学杂志,2016,40(2):100.[doi:10.3760/cma.j.issn.1673-4114.2016.02.003]
 Li Jingtao,Deng Lei,Zhang Wenjue,et al.Risk factor analysis for predicting radiation pneumonitis in extensive stage small cell lung cancer patients receiving IMRT thoracic radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):100.[doi:10.3760/cma.j.issn.1673-4114.2016.02.003]
[2]张毓艺,姚稚明.18F-FDG PET/CT对非小细胞肺癌淋巴结分期诊断价值的研究进展[J].国际放射医学核医学杂志,2016,40(6):447.[doi:10.3760/cma.j.issn.1673-4114.2016.06.009]
 Zhang Yuyi,Yao Zhiming.The progress of 18F-FDG PET/CT in the diagnosis of N-staging of non-small cell lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):447.[doi:10.3760/cma.j.issn.1673-4114.2016.06.009]
[3]李欢欢,李素平,游金辉.小细胞肺癌伴副肿瘤综合征患者骨显像示肌肉摄取一例[J].国际放射医学核医学杂志,2014,38(2):140.[doi:10.3760/cma.j.issn.1673-4114.2014.02.016]
[4]戈畅,梁硕.化疗联合DC-CIK生物治疗非小细胞肺癌的临床价值及CT灌注成像的疗效评价[J].国际放射医学核医学杂志,2014,38(6):377.[doi:10.3760/cma.j.issn.1673-4114.2014.06.007]
 Ge Chang,Liang Shuo.The clinical value and CT perfusion evaluation in chemotherapy combined with DC-CIK biological treatment of non-small cell lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(1):377.[doi:10.3760/cma.j.issn.1673-4114.2014.06.007]
[5]黄少祥,樊体强.塞来昔布对非小细胞肺癌移植瘤的辐射增敏实验研究[J].国际放射医学核医学杂志,2013,37(3):150.[doi:10.3760/cma.j.issn.1673-4114.2013.03.006]
 HUANG Shao-xiang,FAN Ti-qiang.Radiosensitization on non-small cell lung cancer induced by celecoxib[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(1):150.[doi:10.3760/cma.j.issn.1673-4114.2013.03.006]
[6]龙再颖,汤春静,于立明,等.甲状腺乳头状癌术后刺激状态Tg与颈部淋巴结转移关系的研究[J].国际放射医学核医学杂志,2013,37(1):27.[doi:10.3760/cma.j.issn.1673-4114.2013.01.008]
 LONG Zai-ying,TANG Chun-jing,YU Li-ming,et al.The correlation between the stimulated thyroglobulin level after surgery in papillary thyroid carcinoma and cervical lymph node metastasis[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(1):27.[doi:10.3760/cma.j.issn.1673-4114.2013.01.008]
[7]于丽娟,李迎辞,王文志,等.PET-CT及PET-CT结合Lung VCAR软件对非小细胞肺癌肺门区淋巴结的诊断分析[J].国际放射医学核医学杂志,2012,36(6):323.[doi:10.3760/cma.j.issn.1673-4114.2012.06.002]
 YU Li-juan,LI Ying-ci,WANG Wen-zhi,et al.Value of PET-CT and PET-CT combined with Lung VCAR software in the diagnosis of hilar area lymph nodes of non-small cell lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(1):323.[doi:10.3760/cma.j.issn.1673-4114.2012.06.002]
[8]刘莉,杨景魁.125I粒子植入治疗非小细胞肺癌的护理及辐射防护[J].国际放射医学核医学杂志,2012,36(3):172.[doi:10.3760/cma.j.issn.1673-4114.2012.03.013]
 LIU Li,YANG Jing-kui.Radiation protective nursing intervene of 125I seed implantation in non-small cell lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(1):172.[doi:10.3760/cma.j.issn.1673-4114.2012.03.013]
[9]朱晓琳,李强.肝腺瘤的影像诊断现状及进展[J].国际放射医学核医学杂志,2011,35(2):124.[doi:10.3760/cma.j.issn.1673-4114.2011.02.014]
 ZHU Xiao-lin,LI Qiang.Status and advances in imaging diagnsis of hepatic adenoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(1):124.[doi:10.3760/cma.j.issn.1673-4114.2011.02.014]
[10]梁吉祥,柴树德,郑广钧,等.CT引导下植入125I粒子治疗非小细胞肺癌切除术后局部复发的疗效[J].国际放射医学核医学杂志,2011,35(3):181.[doi:10.3760/cma.j.issn.1673-4114.2011.03.012]
 LIANG Ji-xiang,CHAI Shu-de,ZHENG Guang-jun,et al.CT-guided percutaneous interstitial implantation of 125I for recurrent patients of postoperative non-small cell lung carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(1):181.[doi:10.3760/cma.j.issn.1673-4114.2011.03.012]
[11]万绪明,许祖闪,侯红军.磁共振表观弥散系数变化率对肝细胞肝癌患者单次TACE术后疗效评价的应用价值[J].国际放射医学核医学杂志,2015,39(2):129.[doi:10.3760/cma.j.issn.1673-4114.2015.02.006]
 Wan Xuming,Xu Zushan,Hou Hongjun.Applieation value of the change ratio of apparent diffusion coefficient in the therapeutic evaluation of hepatocellular carcinoma treated by single transcatheter arterial chemoembolization[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):129.[doi:10.3760/cma.j.issn.1673-4114.2015.02.006]
[12]王振光,王洋洋.PET/CT显像在肝细胞肝癌诊断中的研究进展[J].国际放射医学核医学杂志,2015,39(2):175.[doi:10.3760/cma.j.issn.1673-4114.2015.02.016]
 Wang Zhenguang,Wang Yangyang.The development of PET/CT imaging in the diagnosis of hepatocellular carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):175.[doi:10.3760/cma.j.issn.1673-4114.2015.02.016]
[13]张一秋,石洪成.肝细胞癌肿瘤新生血管影像学评价的研究进展[J].国际放射医学核医学杂志,2013,37(1):60.[doi:10.3760/cma.j.issn.1673-4114.2013.01.015]
 ZHANG Yi-qiu,SHI Hong-cheng.Advances in assessment of imaging examination for tumor neoangiogenesis induced by hepatocellular carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(1):60.[doi:10.3760/cma.j.issn.1673-4114.2013.01.015]
[14]李红兵,陈勇,曾建国,等.肝动脉化疗性栓塞结合Ⅱ期手术切除治疗巨块型外生型肝癌[J].国际放射医学核医学杂志,2010,34(1):49.[doi:10.3760/cma.j.issn.1673-4114.2010.01.013]
 LI Hong-bing,CHEN Yong,ZENG Jian-guo,et al.Treatment of massive extrahepatic growing hepatocellular carcinoma with TACE in combination with secondary resection[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(1):49.[doi:10.3760/cma.j.issn.1673-4114.2010.01.013]
[15]周云,刘璐,宋进华.经肝动脉灌注90Y微球治疗肝癌的研究进展[J].国际放射医学核医学杂志,2006,30(6):321.
 ZHOU Yun,LIU Lu,SONG Jin-hua.Clinical researched progress of intra-arterial radioembolization with 90Y-glass microspheres for treatment of hepatocellular carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(1):321.
[16]麻广宇,刘家金,徐白萱,等.11C-乙酸盐PET/CT显像在中、高分化肝细胞肝癌复发与转移监测中的应用研究[J].国际放射医学核医学杂志,2018,(4):312.[doi:10.3760/cma.j.issn.1673-4114.2018.04.004]
 Ma Guangyu,Liu Jiajin,Xu Baixuan,et al.Application of 11C-acetate PET/CT imaging in the detection of recurrence and metastasis of hepatocellular carcinoma with intermediate and high differentiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(1):312.[doi:10.3760/cma.j.issn.1673-4114.2018.04.004]
[17]赵竞,张占文,马慧,等.PET/CT显像剂18F-氟丙酸在肝癌中的生物学评估[J].国际放射医学核医学杂志,2018,(5):414.[doi:10.3760/cma.j.issn.1673-4114.2018.05.005]
 Zhao Jing,Zhang Zhanwen,Ma Hui,et al.Biological evaluation of PET/CT imaging agent 18F-fluoropropionic acid in hepatocellular carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(1):414.[doi:10.3760/cma.j.issn.1673-4114.2018.05.005]
[18]陈佩和,徐文贵,李小凤,等.肝细胞肝癌的葡萄糖代谢机制及在PET显像中的应用价值[J].国际放射医学核医学杂志,2018,(6):547.[doi:10.3760/cma.j.issn.1673-4114.2018.06.013]
 Chen Peihe,Xu Wengui,Li Xiaofeng,et al.Glycometabolism mechanism in hepatocellular carcinoma and its application in PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(1):547.[doi:10.3760/cma.j.issn.1673-4114.2018.06.013]

备注/Memo

备注/Memo:
收稿日期:2007-06-15。
通讯作者:李前伟,E-mail:liqw@mail.tmmu.com.cn
更新日期/Last Update: 1900-01-01