[1]胡晓云,胡春洪,方向明,等.脑胶质瘤的11C-甲硫氨酸和11C-胆碱PET和PET-CT[J].国际放射医学核医学杂志,2008,32(1):20-23.
　HU Xiao-yun,HU Chun-hong,FANG Xiang-ming,et al.The application of 11C-methionine and 11C-choline in PET and PET-CT for cerebral gliomas[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(1):20-23.
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脑胶质瘤的11C-甲硫氨酸和11C-胆碱PET和PET-CT(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第1期
页码:
20-23
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The application of 11C-methionine and 11C-choline in PET and PET-CT for cerebral gliomas
作者:
胡晓云;  胡春洪;  方向明;  吴翼伟
215006 苏州, 苏州大学附属第一医院影像中心
Author(s):
HU Xiao-yun;  HU Chun-hong;  FANG Xiang-ming;  WU Yi-wei
Medico]Imaging Center, the First Affiliated Hospitol of Soochow University, Suzhou 215006, China
关键词:
神经胶质瘤; 体层摄影术; 发射型计算机; 体层摄影术; X线计算机; 11C-甲硫氨酸; 11C-胆碱
Keywords:
Gliomas; Tomography; emission-computed; Tomography; X-ray computed; 11C-methionine; 11C-choline
分类号:
R817.4
摘要:
18F-氟脱氧葡萄糖(18F-FDG)在脑肿瘤检查中较常用的诊断用显像剂,但由于其正常的生理分布和自身的缺点影响了其在胶质瘤术前尤其是治疗后的诊断和评估。研究表明,11C标记的甲硫氨酸(11C-MET)和胆碱(11C-胆碱)在脑胶质瘤PET和PET-CT检查中的术前诊断价值、疗效监测以及治疗后肿瘤复发或残存与放射性坏死或治疗后反应的鉴别和评估方面克服了18F-FDG的局限性,是18F-FDG PET和PET-CT的一个重要替代或补充。
Abstract:
18F-fluorodeoxyglucose (18F-FDG) was wildly used radiopharmaceuticals for brain tumors. However, the diagnosis and evaluation of 18F-FDG in cerebral gliomas of pre-and post-therapy were affected due to its normal biodistribution and natural pitfalls. The researches indicates that both 11C-methionine (11C-MET) and 11C-choline overcome the limitations of 18F-FDG, and become an important surrogate or supplement in PET and PET-CT for cerebral gliomas through these aspects of the pretherapeutic diagnostic value, monitoring of therapeutic effects, and the differential diagnosis and assessment between the recurrent or residual tumors and radiation necrosis or post-therapeutic response.

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备注/Memo

备注/Memo:
收稿日期:2007-06-11。
通讯作者:胡晓云,E-mail:drhxy@yahoo.com.cn
更新日期/Last Update: 1900-01-01