[1]周云,刘璐,宋进华.经肝动脉灌注90Y微球治疗肝癌的研究进展[J].国际放射医学核医学杂志,2006,30(6):321-324.
 ZHOU Yun,LIU Lu,SONG Jin-hua.Clinical researched progress of intra-arterial radioembolization with 90Y-glass microspheres for treatment of hepatocellular carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(6):321-324.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第6期
页码:
321-324
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Clinical researched progress of intra-arterial radioembolization with 90Y-glass microspheres for treatment of hepatocellular carcinoma
作者:
周云1 刘璐1 宋进华2
1. 210009 南京, 东南大学核医学技术研究所;
2. 210006 南京, 南京医科大学附属南京第一医院放射介入科
Author(s):
ZHOU Yun1 LIU Lu1 SONG Jin-hua2
1. Department of Nuclear Medical Technique, Southeast University, Nanjing 210009, China;
2. Department of Interventional Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
关键词:
肝细胞钇放射性同位素放射学介入性栓塞治疗性
Keywords:
Carcinoma hepatocellularYttrinm radioisotopasRadiology interventionalEmbolization therapeutic
分类号:
R817.8
摘要:
近年来,肿瘤核素内照射治疗的研究取得了很大的进展。90Y被视为绿色无公害核素备受关注。90Y玻璃微球通过肝动脉给药,可以发挥栓塞肿瘤供血动脉和内照射治疗肿瘤的双重作用,具有操作简单、适应证广泛、不良反应少及肿瘤响应明显等优点,有效地提高了患者的生存率和中位生存期。随着微球材料技术的进一步发展,90Y微球肝动脉灌注可能成为治疗肝癌患者安全有效、具有广阔临床应用前景的新方法。
Abstract:
In recent years, the research of tumor nuclide internal radiation treatment has been carried out encouraging result. 90Y has been regarded green non-environmental damage nuclide. Intrahepatic arterial injection of 90Y-glass microspheres perform dual function at embolism tumor blood supply artery and the internal radiation treatment tumor. It has many merits include simplified operation, wide-ranging indication, side effect few and the tumor response obvious. And the patient’s survival rate and position lifetime has been effective enhanced. Along with the further development of microspheres material technique, this method will entirely possible to achieve a new effective and safe therapy for the patient and has extensively clinical foreground.

参考文献/References:

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2 Carr BI. Hepatocellular carcinoma:current management and futuret rends. Gastroenterology, 2004, 127(5 Suppl 1):S218-S224.
3 Berdonosov SS, Berdonosova DG, Znamenskaya NV. Sorption of 90Sr and 90Y with the vaterite modification of calcium carbonate.Radiochemistry, 2003, 45(6):613-615.
4 Ho S, Lau WY, Leung TW, et al. Clinical evaluation of the partition model for estimating radiation doses from yttrium-90 microspheres in the treatment of hepatic cancer. Eur J Nucl Med, 1997,24(3):293-298.
5 Wong CY, Salem R, Qing F, et al. Metabolic response after intraarterial 90Y-glass microsphere treatment for colorectal liver metastases:comparison of quantitative and visual analyses by 18F-FDG PET. J Nucl Med, 2004, 45(11):1892-1897.
6 Salem R, Lewandowski R, Roberts C, et al. Use of Yttrium-90 glass microspheres (Thera-Sphere) for the treatment of unresectable hepatocellular carcinoma in patients with portal vein thrombosis. J Vasc Interv Radiol, 2004, 15(4):335-345.
7 Cao X, He N, Sun J, et al. Hepatic mdioembolization with Yttrium-90 glass microspheres for treatment of primary liver cancer. Chin Med J (Engl), 1999, 112(5):430-432.
8 Dancey JE, Shepherd FA, Paul K, et al. Treatment of nonresectable hepatocellular carcinoma with intrahepatic 90Y microspheres. J Nucl Med, 2000, 41(10):1673-1681.
9 Sarfaraz M, Kennedy AS, Lodge MA, et al. Radiation absorbed dose distribution in a patient treated with yttrium-90 microspheres for hepatocellular carcinoma. Med Phys, 2004, 31(9):2449-2453.
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18 Lee HS, KIm JS, Choi IJ, et al. The safety and efficacy of transcatheter arterial chemcembolization in the treatment of patients with hepatocellular carcinoma and main portal vein obstruction. Cancer,1997, 79(11):2087-2094.

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备注/Memo

备注/Memo:
收稿日期:2006-04-23。
基金项目:国家自然科学基金资助项目(30470500)
通讯作者:刘璐,E-mail:luliuzhou@sina.com
更新日期/Last Update: 1900-01-01