[1]覃伟武.131Ⅰ治疗非Graves’甲状腺功能亢进及非毒性甲状腺肿后诱发Graves’病[J].国际放射医学核医学杂志,2006,30(6):325-327.
 QIN Wei-wu.Induction of Graves’ disease in patients with non-autoimmune hyperthyroidism or nontoxic goiter after radioiodine treatment[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(6):325-327.
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131Ⅰ治疗非Graves’甲状腺功能亢进及非毒性甲状腺肿后诱发Graves’病(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第6期
页码:
325-327
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Induction of Graves’ disease in patients with non-autoimmune hyperthyroidism or nontoxic goiter after radioiodine treatment
作者:
覃伟武
530021 南宁, 广西医科大学第一附属医院核医学科
Author(s):
QIN Wei-wu
Department of Nuclear Medicine, The Fist Affiliated Hospital of Guanxi Medical University, Nanning 530021, China
关键词:
碘放射性同位素放射疗法格雷夫斯病甲状腺功能亢进症甲状腺肿
Keywords:
Iodine radioisotopesRadiotherapyGraves’ diseaseHyperthyroidismGoiter
分类号:
R817.8
摘要:
131Ⅰ治疗非Graves’甲亢及非毒性甲状腺肿后数月,少部分患者体内出现促甲状腺激素受体抗体并诱发Graves’病(GD),发病率在0.05%-5%之间。其发病机制假说有通过自身免疫反应介导等。通过监测体内甲状腺自身抗体水平变化、甲状腺显像,可以预测131Ⅰ治疗后GD的发生。其治疗方法有抗甲状腺药物治疗、再次放射性131Ⅰ治疗、手术治疗。
Abstract:
Thyrotropin receptors antibodies may occur and induce Graves’ disease (GD) several months after radioiodine therapy in a small number of patients with nontoxic goiter. The prevalence of radiation-induced GD is between 0.05% and 5%. The hypothesis of this disease includes induction by autoimmune reaction and others. Detection of the thyroid autoantibodise or of 99mTc pertechnetate scan can forecast the appearance of GD. Anfithyroid drugs,again radioiodine therapy and surgery are the treatments.

参考文献/References:

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3 Wallaschofsld H, Muller D, Georgi P, et al. Induction of TSH-receptor antibodies in patients with toxic multinodular goitre by radioiodine treatment. Horm Metab Res, 2002, 34(1):36-39.
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6 Dunkelmann S, Wolf R, Koch A, et al. Incidence of radiationinduced Graves’ disease in patients treated with radioiodine for thyroid autonomy before and after introduction of a high-sensitivity TSH receptor antibody assay. Eur J Nucl Med Mol Imaging, 2004,31(10):1428-1434.
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8 Nygaard B, Faber J, Veie A, et al. Transition of nodular toxic goiter to autoimmune hyperthyroidism triggered by 131Ⅰ therapy.Thyroid, 1999, 9(5):477-481.
9 Weiss M, Gorges R, Hirsch C, et al. Incidence of immunogenic hyperthyroidism after radioiodine therapy of focal thyroid gland autonomy. Results of a multicenter study. Med Klin (Munich), 1999,94(5):239-244.
10 Giovanella L, Ceriani L, C, arancini S. Evaluation of the 2nd generation radio-receptional assay for anti-TSH receptor antibodies(TRAb) in autoimmune thyroid diseases. Q J Nucl Med, 2001, 45(1):115-119.
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12 Custro N, Ganci A, Scafidi V, et al. Relapses of hyperthyroidism in patients treated with radioiodine for nodular toxic goiter:relat-ion to thyroid autoimmunjty. J Endocrinol Invest, 2003, 26(2):106-110.
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备注/Memo

备注/Memo:
收稿日期:2006-05-10。
更新日期/Last Update: 1900-01-01