[1]崔丽群,张承刚,李玲玲.小剂量131I治疗青少年Graves’病85例患者疗效观察[J].国际放射医学核医学杂志,2007,31(4):226-228.
　CUI Li-qun,ZHANG Cheng-gang,LI Ling-ling.The observation of curative effects by therapy with low-dose 131I in younger with Graves’ disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(4):226-228.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第4期
页码:
226-228
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The observation of curative effects by therapy with low-dose 131I in younger with Graves’ disease
作者:
崔丽群1;  张承刚2;  李玲玲1
1. 030600 山西, 山西省晋中市第一人民医院核医学科;
2. 030001 太原, 山西医科大学第一医院核医科
Author(s):
CUI Li-qun1;  ZHANG Cheng-gang2;  LI Ling-ling1
1. Department of Nuclear Medicine, The first people’s Hospital of Jinzhong, Shanxi 030600, China;
2. Department of Nuchar Medicine, No.1 Hospital of Shanxi Medical University, Taiyuan 030001, China
关键词:
格雷夫斯病; 碘放射性同位素; 放射疗法; 抗甲状腺药
Keywords:
Graves’ disease; Idine Isotopes; Radiotherapy; Antithyroid drug
分类号:
R817.5
摘要:
目的 探讨小剂量131I治疗青少年Graves’病的疗效。方法 均采用131I治疗,每克甲状腺组织给131I为1480~2220 kBq,并结合患者年龄、甲状腺质量、病程、是否曾用过抗甲状腺药物治疗等进行综合考虑确定131I治疗剂量。参照对131I治疗后疗效评价标准,将治疗结果分为完全缓解(包括甲状腺功能正常和甲状腺功能减退)、显效、部分缓解、无效。结果 85例患者中,一次治疗完全缓解41例,显效34例,部分缓解10例,无效为0,总有效率为100%。结论 小剂量131I是治疗青少年Graves’病有效、简便、安全的方法,重复治疗可以提高Graves’病的治愈率,不会明显增加甲状腺功能减退的发生率。
Abstract:
Objective To observe the the curative effects in younger with Graves disease therapied by 131I. Methods The dose of 131I is administrated with 1480~2220kBq/g of thyroid tissue which was decided by many factors that include the patient’s Age, volume of thyroid, course and if antihyroid drug is administrated. The curative effects was classfide into four groups: complete remission, excellence, parts of remission, no effect. Results 47 were complete remission, 34 were excellence, 10 were the parts of remission and 0 was no effects. The total effective power was 100%. Conclusions Therapy with low-dose of 131I for younger with Graves’ disease is an effect, simple and safe method. Repeating treatment with, 131I will improve the curative rate of Graves’ disease in younger, and the incidence of hypothyroidism cannot be increased.

参考文献/References:

1 秦岚,尹乐等. 131I治疗青少年甲亢的疗效观察.中国青年核医学论坛,2003,3(1):28-29.
2 张承刚. 放射性131I治疗甲状腺功能亢进症的方法学.见:张承刚主编. 甲状腺疾病核素治疗学,第一版,北京:原子能出版社,2003,188-189.
3 王勤奋,李宝兰,张承刚. 治疗甲状腺功能亢进症的疗效评价.见:张承刚主编. 甲状腺疾病核素治疗学,第一版,北京:原子能出版社,2003.325-326.
4 段东等.131I治疗青少年甲亢的临床观察.重庆医科大学学报,2002,27(1):96-99.
5 徐海青,吴边. 131I合并小剂量碳酸锂治疗Graves病的临床探讨.国际放射医学核医学杂志,2006,30(3):151-152.

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备注/Memo

备注/Memo:
收稿日期:2007-04-04。
通讯作者:崔丽群(E-mail:clq0329@163.com)
更新日期/Last Update: 1900-01-01