[1]闫瑾,林祥通.PET预测及评价肿瘤疗效的新进展[J].国际放射医学核医学杂志,2006,30(4):214-217.
 YAN Jin,LIN Xiang-tong.The new advance of prediction and evaluation of tumor therapeutic effects by PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(4):214-217.
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PET预测及评价肿瘤疗效的新进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第4期
页码:
214-217
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The new advance of prediction and evaluation of tumor therapeutic effects by PET
作者:
闫瑾 林祥通
200040 上海, 复旦大学附属华山医院核医学科
Author(s):
YAN Jin LIN Xiang-tong
Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
关键词:
体层摄影术发射型计算机血管生成细胞凋亡低氧增殖
Keywords:
Tomography emission-computedAngiogenesisApoptosisHypoxiaProliferation
分类号:
R817.4
摘要:
临床上评价及预测肿瘤疗效的手段很多,包括体格检查、普通影像学检查(X线摄片、CT、MRI等)和肿瘤标志物检测等,但这些方法均有很大的局限性,如主观性强、敏感性差等。PET可以早期准确地反映肿瘤相关生物特征,如血管生成、凋亡、乏氧和增殖等。因此,利用相应的可反映上述生物特征的显像剂行PET,可对肿瘤进行早期诊断、评价和预测肿瘤治疗的疗效,协助临床医生制定治疗方案。
Abstract:
There are many methods that evaluate and predicate the therapeutic effects of tumors, including physical examination, common imaging (X-ray, CT, MRI etc) and tumor marker etc. But these methods have many limits, for example:more subjective, less sensitivity etc. The relative biological features as angiogenesis, apoptosis, hypoxic and proliferation can be reflected by PET early and correctly. So, we can diagnose tumor, predict and evaluate its therapeutic effects by PET used the accorded tracers that reflect the above biological features. Helping clinical doctors to make therapeutic methods.

参考文献/References:

1 Folkman J.The role of angiogenesis in tumor growth.Semin Cancer Biol,1992,3(2):65-71.
2 Gasparini G,Toi M,Biganzoli E,et al.Thrombospondin-1 and -2 in node-negative breast cancer:correlation with angiogenic factors,p53,cathepsin D,hormone receptors and prognosis.Oncology,2001,60(1):72-80.
3 Fidler IJ.Angiogenesis and cancer metastasis.Cancer,2000,6(Suppl 2):S134-S141.
4 Blankenberg FG,Naumovshi L,Tait JF,et al.Imaging cyclophosphamide-induced intramedullary apoptosis in rats using 99mTc-radiolabeled annexin V.J Nucl Med,2001,42(2):309-316.
5 Yang DJ,Azhdarinia A,Wu P,et al.In vivo and in vitro measurement of apoptosis in breast cancer cells using 99mTc-EC-annexin V.Cancer Biother Radiopharm,2001,16(1):73-83.
6 Bos R,Zhong H,Hanrahan GF,et al.Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis.J Natl Cancer Inst,2001,93(4):309-314.
7 Koumenis C,Alsrcon R,Hammond E,et al.Regulation of P53 byhypoxia dissociation of transcriptional repression and apoptosis from P53-dependent transactivition.Mol CellBiol,2001,21(4):.1297-1310.
8 Quinn CM,Wright NA.The clinical assessment of proliferation and growth in human tumours:evaluation of methods and applications as prognostic variables.J Pathol,1990,160(2):93-102.
9 Buck AK,Schirrmeister H,Hetzel M,et al.3-deoxy-3-[(18) F]fluorothymidine-positron emission tomography for noninvasive assessment of proliferation in pulmonary nodules.Cancer Res,2002,62(12):3331-3334.
10 Weissleder R,Tunyg CH,Mahmood U,et al.In vivo imaging of tumors with protease-activated near-infrared fluorescent probes.Nt Biotechnol,1999,17(4):375-378.
11 Mhmood U,Tung CH,Bogdanov A,et al.Near-infrared optical Imaging of protease activity for tumor detection.Radiology,1999,213(3):866-870.

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备注/Memo

备注/Memo:
收稿日期:2006-04-29。
通讯作者:闻瑾,E-mail:yj730419@163.com
更新日期/Last Update: 1900-01-01