[1]高颖.辐射对骨髓造血微环境影响的研究进展[J].国际放射医学核医学杂志,2000,24(4):183-185.
 GAO Ying.Curent developments in the study of effects of irradiation on bone marrow haematopoietic microenvironment[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(4):183-185.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
24
期数:
2000年第4期
页码:
183-185
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Curent developments in the study of effects of irradiation on bone marrow haematopoietic microenvironment
作者:
高颖
300020 天津, 中国医学科学院, 中国协和医科大学血液学研究所
Author(s):
GAO Ying
Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China
关键词:
辐射骨髓基质细胞生长因子粘附分子
Keywords:
irradiationbone marrow stroma cellgrowth factoradhesion molecule
分类号:
Q691.5
摘要:
骨髓造血完全依赖骨髓微环境的支持和调控,早期和近期的观察均提出了辐射对骨髓造血微环境基质细胞的远期影响,并发现在某些实验条件下,辐射后基质细胞的集落刺激能力上升,生长因子(如GM-GSF)和粘附分子(如VCAM-1)表达升高。
Abstract:
Hemotopoiesis completely depends on the regulation of the microenvironment. It has been indicated in the early and recent study the long-term effects of radiation on bone marrow microenvironment. It has been found in some experiments that after radiation the colony stimulating activity, the expression of growth factor (GMCSF) and adhesion molecule(V CAM-1) of the stroma cells was elevated.

参考文献/References:

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[8] Dave B, Watanabe T, Singh RK, et al. Growth factor mobilization and modulation of progenitor cell adhesion to stromal cells:role of VLA-4[J]. J Hematother Stem Cell Res, 2000, 9(4):507-515.
[9] Papayannopoulou T and Craddock C. Homing and trafficking of hemopoietic progenitor cells[J]. Acta Haematol, 1997, 97(1-2):97-104.
[10] Papayannopoulou T, Craddock C, Nakamoto B, et al. The VLA-4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen[J]. Proc Natl Acad Sci, 1995, 92:9647-9851.
[11] Oostendorp RAJ, Reisbach G, Spitzer E, et al. VLA-4 and VCAM-lare the principal adhesion molecules involved in the interaction between blast clolny-forming cells and bone marrow stromal cells[J]. Br J Haematol, 1995, 91:275-284.
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备注/Memo

备注/Memo:
收稿日期:2000-07-03。
作者简介:高颖(1972-),女,江苏无锡人,中国医学科学院、中国协和医科大学血液学研究所基础部实习研究员,硕士,主要从事造血微环境研究。
更新日期/Last Update: 1900-01-01