[1]汪会,徐慧琴.肿瘤乏氧显像剂的研究进展[J].国际放射医学核医学杂志,2012,36(6):366-370.[doi:10.3760/cma.j.issn.1673-4114.2012.06.011]
 WANG Hui,XU Hui-qin.Advances in study of tumor hypoxia imaging agents[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(6):366-370.[doi:10.3760/cma.j.issn.1673-4114.2012.06.011]
点击复制

肿瘤乏氧显像剂的研究进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
36
期数:
2012年第6期
页码:
366-370
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Advances in study of tumor hypoxia imaging agents
作者:
汪会 徐慧琴
安徽医科大学第一附属医院核医学科, 合肥 230022
Author(s):
WANG Hui XU Hui-qin
Department of Nuclear Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
关键词:
肿瘤正电子发射断层显像术体层摄影术发射型计算机单光子乏氧显像剂
Keywords:
NeoplasmsPositron-emission tomographyTomography emission-computed single-photonHypoxia imaging agents
DOI:
10.3760/cma.j.issn.1673-4114.2012.06.011
摘要:
实体瘤快速生长,中央区血供不充分,导致乏氧区存在。而乏氧肿瘤细胞是影响肿瘤治疗效果的主要因素。乏氧显像剂能选择性地滞留在乏氧组织或细胞中,通过PET或SPECT可无创性评估实体瘤的乏氧状态,对肿瘤的治疗指导、疗效评价和预后判断具有很大的实用价值。该文简要介绍了乏氧显像剂的研究进展。
Abstract:
Solid tumors cause regional hypoxia when they outgrow the blood supply. The presence of hypoxia cells within the tumor is the primary factor influencing the effect of therapy. Hypoxia imaging agents selectively accumulate in the oxygen deficient organizations or cells that can be detected by the non-invasive methods such as PET and SPECT. It has great practical value in guiding treatment, evaluating efficacy and accessing prognosis. This review briefly introduces the research progress of tumor hypoxia imaging agents.

参考文献/References:

[1] Nakamura S.Structure of Azomycin,a new aruibiotic.Pharm Bull,1955,3(5):379-383.
[2] Troost EG,Laverman P,Philippens ME,et al.Correlation of[18F] FMISO autoradiography and pimonidazole immunohistochemistry in human head and neck carcinoma xenografts.Eur J Nucl Med Mol Iamging,2008,35(10):1803-1811.
[3] Valable S,Petit E,Roussel S,et al.Complementary information from magnetic resonance imaging and 18F-fluoromisonidazole positron emission tomography in the assessment of the response to an antiangiogenic treatment in a rat brain tumor model.Nucl Med Biol,2011,38(6):781-793.
[4] Rajendran JG,Schwartz DL,0’Sullivan J,et al.Tumor hypoxia imaging with[18F] fluoromisonidazole positron emission tomography in head and neck cancer.Clin Cancer Res,2006,12(18):5435-5441.
[5] Kurihara H,Honda N,Kono Y,et al.Radiolabelled agents for PET imaging of tumor hypoxia.Curr Med Chem,2012,19(20):3283-269.
[6] Yamamoto Y,Maeda Y,Kawat N,et al.Hypoxia assessed by 18F-fluoromisonidazole positron emission tomography in newly diagnosed gliomas.Nucl Med Commun,2012,33(6):621-625.
[7] Hayashi K,Furutsuka K,Takei M,et al.High-yield automated synthesis of[18F] fluoroazomycin arabinoside([18F]FAZA) for hypoxia-specific tumor imaging.Appl Radiat Isot,2011,69(7):1007-1013.
[8] Bouvet VR,Wuest M,Wiebe Li,et al.Synthesis of hypoxia imaging agent 1-(5-deoxy-5-fluoro-α-D-arabinofuranosyl)-2-nitroimidazole using microfluidic technology.Nucl Med Biol,2011,38(2):235-245.
[9] Mortensen LS,Busk M,Nordsmark M,et al.Accessing radiation response using hypoxia PET imaging and oxygen sensitive electrodes:a preclinical study,Radi other Oncol,2011,99(3):418-423.
[10] Zha Z,Zhu L,Liu Y,et al.Synthesis and evaluation of two novel 2-nitroimidazole derivatives as potential PET radioligands for tumor imaging.Nucl Med Biol,2011,38(4):501-508.
[11] Vercellino L,Groheux D,Thoury A,et al.Hypoxia imaging of uterine cervix carcinoma with 18F-FETNIM PET-CT.Clin Nucl Med,2012,37(11):1065-1068.
[12] Chen L,Zhang Z,Kolb HC,et al.18F-HX4 hypoxia imaging with PET-CT in head and neck cancer:a comparison with 18F-FMISO.Nucl Med Commun,2012,33(10):1096-1102.
[13] Mahy P,De Bast M,Gillart J,et al.Detection of tumour hypoxia:comparison between EF5 adducts and[18F]-EF3 uptake on an individual mouse tumour basis.Eur J Nucl Med Mol Imaging,2006,33(5):553-556.
[14] Mahy P,De Bast M,De Groot T,et al.Comparative pharmacokinetics,biodistribution,metabolism and hypoxia-dependent uptake of[18F]-EF3 and[18F]-MISO in rodent tumor models.Radiother Oncol,2008,89(3):353-360.
[15] Dubois L,Landuyt W,Cloetens L,et al.[18F]EF3 is not superior to[18F]FMISO for PET-based hypoxia evaluation as measured in a rat rhabdomyosarcoma tumour model.Eur J Nucl Med Mol Imaging,2009,36(2):209-218.
[16] Reischl G,Dorow DS,Cullinance C,et al.Imaging of tumor hypoxia with[124I]IAZA in comparison with[18F]FMISO and[18F]FAZA-first small animal PET results.J Pharm Pharm Sci,2007,10(2):203-211.
[17] Riedl CC,Brader P,Zanzonico P,et al.Tumor hypoxia imaging in orthotopic liver tumors and peritoneal metastasis:a comparative study featuring dynamic 18F-MISO and 124I-IAZG PET in the same study cohort.Eur J Nucl Med Mol Imaging,2008,35(1):39-46.
[18] Vera P,Bohn P,Edet-Sanson A,et al.Simultaneous positron emission tomography(PET) assessment of metabolism with 18F-fluoro-2-deoxy-d-glucose(FDG),proliferation with 18F-fluorothymidine(FLT),and hypoxia with 18Fluoro-misonidazole(F-miso) before and during radiotherapy in patients with non-small-cell lung cancer(NSCLC):a pilot study.Radiother Oncol,2011,98(1):109-116.
[19] Christian N,Deheneffe S,Bol A,et al.Is 18F-FDG a surrogate tracer to measure tumor hypoxia? Comparison with the hypoxic tracer 14C-EF3 in animal tumor models,Radiother Oncol,2010,97(2):183-188.
[20] Kaira K,Endo M,Abe M,et al.Biologic correlates of 18F-FDG uptake on PET in pulmonary pleomorphic carcinoma.Lung Cancer,2011,71(2):144-150.
[21] Yoshii Y,Yoneda M,Ikawa M,et al.Radiolabeled Cu-ATSM as a novel indicator of overreduced intracellular state due to mitochondrial dysfunction:studies with mitochondrial DNA-less ρ0 cells and cybrids carrying MELAS mitochondrial DNA mutation.Nucl Med Biol,2012,39(2):177-185.
[22] Dence CS,Ponde DE,Welch MJ,et al.Autoradiographic and small-animal PET comparisons between 18F-FMISO,18F-FDG,18F-FLT and the hypoxia selective 64Cu-ATSM in a rodent model of cancer.Nucl Med Biol,2008,35(6):713-20.
[23] Grigsby PW,Malyapa RS,Hiqashikubo R,et al.Comparison of molecular markers of hypoxia and imaging with 60Cu-ATSM in cancer of the uterine cervix.Mol Imaging Biol,2007,9(5):278-283.
[24] Sun X,Chu T,Wang X.Preliminary studies of 99mTc-BnAO and its analogues:synthesis,radiolabeling and in vitro cell uptake.Nucl Med Biol,2010,37(2):117-123.
[25] Lee BF,Wang LW,Lin SH,et al.Tc-99m-HL91 imaging in the early detection of neuronal injury in a neonatal rat model of hypoxic ischemia.Crit Care Med,2012,40(6):1930-1938.

相似文献/References:

[1]胡伟,赵军.小胶质细胞在AD炎性机制中的作用及其常见PET显像剂的应用进展[J].国际放射医学核医学杂志,2016,40(1):44.[doi:10.3760/cma.j.issn.1673-4114.2016.01.009]
 Hu Wei,Zhao Jun.Microglia’s Alzheimer disease inflammatory mechanisms and progress of its common application in PET imaging agents[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):44.[doi:10.3760/cma.j.issn.1673-4114.2016.01.009]
[2]张莹莹,王振光,孔艳.PET/CT显像在肺间质纤维化中的应用进展[J].国际放射医学核医学杂志,2016,40(1):55.[doi:10.3760/cma.j.issn.1673-4114.2016.01.011]
 Zhang Yingying,Wang Zhenguang,Kong Yan.Application advancement on PET/CT in pulmonary interstitial fibrosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):55.[doi:10.3760/cma.j.issn.1673-4114.2016.01.011]
[3]李海峰,张晓军,李云钢,等.国产模块LOOP环改良法合成11C-蛋氨酸[J].国际放射医学核医学杂志,2016,40(2):106.[doi:10.3760/cma.j.issn.1673-4114.2016.02.004]
 Li Haifeng,Zhang Xiaojun,Li Yungang,et al.Synthesis of 11C-methionine on home-made module by the improved LOOP method[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):106.[doi:10.3760/cma.j.issn.1673-4114.2016.02.004]
[4]史文杰,孟召伟,谭建.基于Deauville标准探讨18F-FDG PET/CT在霍奇金淋巴瘤复发诊断中的应用价值[J].国际放射医学核医学杂志,2016,40(2):120.[doi:10.3760/cma.j.issn.1673-4114.2016.02.007]
 Shi Wenjie,Meng Zhaowei,Tan Jian.Value of 18F-FDG PET/CT on diagnosis of Hodgkin lymphoma recurrence using Deauville criterion[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):120.[doi:10.3760/cma.j.issn.1673-4114.2016.02.007]
[5]陈顺军,程兵.肿瘤细胞凋亡核素显像分子探针研究进展[J].国际放射医学核医学杂志,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
 Chen Shunjun,Cheng Bing.Progress in molecular probes of radionuclide tumor apoptosis imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
[6]陈晓艳,张江虹,邵春林.STAT3与辐射敏感相关性的研究进展[J].国际放射医学核医学杂志,2016,40(3):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
 Chen Xiaoyan,Jianghong,Shao Chunlin.Research progresses of correlation between STAT3 and radiosensitivity[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
[7]李海峰,张晓军,张锦明.多巴胺转运蛋白显像剂11C-β-CFT在帕金森病中的应用研究[J].国际放射医学核医学杂志,2016,40(3):218.[doi:10.3760/cma.j.issn.1673-4114.2016.03.011]
 Li Haifeng,Zhang Xiaojun,Zhang Jinming.Review of the use of dopamine transporter imaging agent 11C-β-CFT for diagnosing Parkinson disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):218.[doi:10.3760/cma.j.issn.1673-4114.2016.03.011]
[8]尤阳,轩昂,张杰,等.淋巴瘤患者大脑静息葡萄糖代谢改变[J].国际放射医学核医学杂志,2016,40(4):255.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
 You Yang,Xuan Ang,Zhang Jie,et al.Changes in resting-state brain glucose metabolism in patients with lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):255.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
[9]王朋,崔邦平,代文莉,等.18F-FDG PET/CT在前列腺癌中的应用进展[J].国际放射医学核医学杂志,2016,40(4):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
 Wang Peng,Cui Bangping,Dai Wenli,et al.Progress in the application of 18F-FDG PET/CT in prostate cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
[10]李菲,黄俊星,张俊.18F-FDG PET/CT在食管癌中的临床应用[J].国际放射医学核医学杂志,2016,40(4):282.[doi:10.3760/cma.j.issn.1673-4114.2016.04.009]
 Li Fei,Huang Junxing,Zhang Jun.The clinical application of 18F-FDG PET/CT in esophageal cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):282.[doi:10.3760/cma.j.issn.1673-4114.2016.04.009]
[11]何燕,苏晋,郑晓霞,等.P-糖蛋白抑制剂在PET显像中的应用研究[J].国际放射医学核医学杂志,2016,40(1):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
 He Yan,Su Jin,ZhengXiaoxia,et al.Developing P-glycoprotein inhibitor marked by PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
[12]许飞,刘建军,黄钢,等.PET乏氧显像在预测肿瘤乏氧及指导临床治疗中的应用进展[J].国际放射医学核医学杂志,2016,40(1):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
 Xu Fei,Liu Jianjun,Huang Gang,et al.The application of hypoxia imaging with PET in predicting tumor hypoxia and guiding clinical therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
[13]陆东燕,侯莎莎,丁恩慈,等.结核性与恶性腹膜弥漫性病变的18F-FDG PET/CT影像特征分析[J].国际放射医学核医学杂志,2014,38(6):398.[doi:10.3760/cma.j.issn.1673-4114.2014.06.012]
 Lu Dong-yan,Hou Sha-sha,Ding En-ci,et al.Analysis of 18F-FDG PET/CT imaging features of tuberculous and cancerous diffuse peritoneal lesions[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(6):398.[doi:10.3760/cma.j.issn.1673-4114.2014.06.012]
[14]刘春利,李毅红.18F-FDG PET/CT在原发灶不明的脑转移瘤中的诊断价值[J].国际放射医学核医学杂志,2013,37(2):92.[doi:10.3760/cma.j.issn.1673-4114.2013.02.008]
 LIU Chun-li,LI Yi-hong.The value of 18F-FDG PET/CT in diagnosing brain metastases from unknown primary tumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(6):92.[doi:10.3760/cma.j.issn.1673-4114.2013.02.008]
[15]王胜军,杨卫东,赵小虎,等.18F-FDG PET/CT诊断多发癌的价值[J].国际放射医学核医学杂志,2013,37(2):96.[doi:10.3760/cma.j.issn.1673-4114.2013.02.009]
 WANG Sheng-jun,YANG Wei-dong,ZHAO Xiao-hu,et al.Value of 18F-FDG PET/CT in the diagnosis of multiple primary malignant neoplasms[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(6):96.[doi:10.3760/cma.j.issn.1673-4114.2013.02.009]
[16]唐宇辉,陈跃.PET/CT在儿科恶性肿瘤中的应用进展[J].国际放射医学核医学杂志,2013,37(2):107.[doi:10.3760/cma.j.issn.1673-4114.2013.02.012]
 TANG Yu-hui,CHEN Yue.The progression of PET/CT in pediatric malignant tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(6):107.[doi:10.3760/cma.j.issn.1673-4114.2013.02.012]
[17]孙爱君,任茜,刘健,等.11C-乙酸盐PET和PET/CT在肿瘤显像中的应用[J].国际放射医学核医学杂志,2013,37(4):243.[doi:10.3760/cma.j.issn.1673-4114.2013.04.013]
 SUN Ai-jun,REN Qian,LIU Jian,et al.The application of 11C-acetate PET and PET-CT for tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(6):243.[doi:10.3760/cma.j.issn.1673-4114.2013.04.013]
[18]辛军,赵周社,李红,等.自适应统计迭代重建技术在PET/CT全身扫描中的应用[J].国际放射医学核医学杂志,2013,37(5):279.[doi:10.3760/cma.j.issn.1673-4114.2013.05.007]
 XIN Jun,ZHAO Zhou-she,LI Hong,et al.Adaptive statistical iterative reconstruction technology in the application of PET/CT whole body scans[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(6):279.[doi:10.3760/cma.j.issn.1673-4114.2013.05.007]
[19]王玉婷,黄钢,蒋瑾,等.18F-FDG PET用于肿瘤治疗疗效评价的meta分析进展[J].国际放射医学核医学杂志,2012,36(6):334.[doi:10.3760/cma.j.issn.1673-4114.2012.06.004]
 WANG Yu-ting,HUANG Gang,JIANG Jin,et al.Tumor response monitoring by 18F-FDG PET: updated review of meta-analyses[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(6):334.[doi:10.3760/cma.j.issn.1673-4114.2012.06.004]
[20]江茂情,吴华.18F-FDG和18F-FLT PET-CT在肿瘤非手术治疗早期疗效评价中的应用[J].国际放射医学核医学杂志,2012,36(6):339.[doi:10.3760/cma.j.issn.1673-4114.2012.06.005]
 JIANG Mao-qing,WU Hua.18F-FDG and 18F-FLT PET-CT in evaluation of the early response of malignant tumors after different therapies[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(6):339.[doi:10.3760/cma.j.issn.1673-4114.2012.06.005]

备注/Memo

备注/Memo:
收稿日期:2012-09-07。
基金项目:安徽省科技计划项目(10021303025)
通讯作者:徐慧琴(Email:hfxuhuiqin@163.com)
更新日期/Last Update: 1900-01-01