[1]孙爱君,任茜,刘健,等.11C-乙酸盐PET和PET/CT在肿瘤显像中的应用[J].国际放射医学核医学杂志,2013,37(4):243-247.[doi:10.3760/cma.j.issn.1673-4114.2013.04.013]
 SUN Ai-jun,REN Qian,LIU Jian,et al.The application of 11C-acetate PET and PET-CT for tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(4):243-247.[doi:10.3760/cma.j.issn.1673-4114.2013.04.013]
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11C-乙酸盐PET和PET/CT在肿瘤显像中的应用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第4期
页码:
243-247
栏目:
综述
出版日期:
2013-07-25

文章信息/Info

Title:
The application of 11C-acetate PET and PET-CT for tumors
作者:
孙爱君1 任茜1 刘健1 Jens S?rensen2
1. 255213 淄博, 万杰肿瘤医院PET中心;
2. 75105 Uppsala, Section of Nuclear Medicine, Uppsala University Hospital
Author(s):
SUN Ai-jun1 REN Qian1 LIU Jian1 Jens S?rensen2
Department of PET Center, Zibo Wanjie Cancer Hospital, Zibo 255213, China
关键词:
乙酸盐类碳放射性同位素肿瘤正电子发射断层显像术体层摄影术X线计算机
Keywords:
AcetatesCarbon radioisotopesNeoplasmsPositron-emission tomographyTomographyX-ray computed
DOI:
10.3760/cma.j.issn.1673-4114.2013.04.013
摘要:
18F-FDG是目前应用最广泛的PET显像剂,但其在脑肿瘤、前列腺癌、头颈部肿瘤、肝癌、泌尿系统肿瘤及高分化肺癌等方面的应用存在局限性。肿瘤对11C-乙酸盐的摄取基于加速的脂质合成和减弱的氧化代谢,能够弥补单纯18F-FDG PET的不足。该文综述了11C-乙酸盐PET、PET/CT的摄取机制及其在上述肿瘤显像中的应用及最新进展。
Abstract:
18F-FDG is currently the most widely used PET tracer.However,its application in the fields of brain tumor,prostate cancer,head and neck cancer,hepatocellular carcinoma,urinary tumor and well differentiated lung cancer exists limitation.Tumor uptake 11C-acetate is based on accelerated lipid synthesis and impaired oxidative metabolism.11C-acetate PET may overcome the insufficiency of 18F-FDG PET.Uptake mechanism,application of the above tumors and the newest progress of 11C-acetate PET and PET/CT are reviewed in this article.

参考文献/References:

[1] Soloviev D,Fini A, Chierichetti F,et al. PET imaging with 11C-acetate in prostate cancer:a biochemical, radiochemical and clinical perspective. Eur J Nucl Med Mol Imaging, 2008,35(5):942-949.
[2] Pike VW, Eakins MN, Allan RM, et al. Preparation of[l-11C] acetate-an agent for the study of myocardial metabolism by positron emission tomography. Int J Appl Radiat Isot, 1982,33(7):505-512.
[3] Luong A,Hannah VC, Brown MS, et al. Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins. J Biol Chem, 2000, 275(34):26458-26466.
[4] Yoshimoto M, Waki A, Yonekura Y,et al. Characterization of acetate metabolism in tumor cells in relation to cell proliferation:acetate metabolism in tumor cells. Nucl Med Biol, 2001, 28(2):117-122.
[5] Yeh SH, Liu RS, Wu LC, et al. 11C-acetate clearance in nasopharyngeal carcinoma. Nucl Med Commun, 1999, 20(2):131-134.
[6] Dusing RW, Drisko JA, Grado GG, et al. Prostate imaging modalities that can be used for complementary and alternative medicine clinical studies. Urol Clin North Am, 2011, 38(3):343-357.
[7] Oyama N, Kim J, Jones LA, et al. MicroPET assessment of androgenic control of glucose and acetate uptake in the rat prostate and a prostate cancer tumor model. Nucl Med Biol, 2002, 29(8):783-790.
[8] Jana S, Blaufox MD. Nuclear medicine studies of the prostate, testes, and bladder. Semin Nucl Med, 2006, 36(1):51-72.
[9] Schoder H, Larson SM. Positron emission tomography for prostate, bladder, and renal cancer. Semin Nucl Med, 2004, 34(4):274-292.
[10] Oyama N, Miller TR, Dehdashti F, et al. 11C-acetate PET imaging of prostate cancer:detection of recurrent disease at PSA relapse. J Nucl Med, 2003, 44(4):549-555.
[11] Fricke E, Machtens S,Hofmann M, et al. Positron emission tomography with 11C-acetate and 18F-FDG in prostate cancer patients. Eur J Nucl Med Mol Imaging, 2003, 30(4):607-611.
[12] Mena E, Turkbey B, Mani H, et al. 11C-Acetate PET/CT in localized prostate cancer:a study with MRI and histopathologic correlation. J Nucl Med, 2012,53(4):538-545.
[13] Sepp?l? J, Sepp?nen M, Arponen E, et al. Carbon-11 acetate PET/CT based dose escalated IMRT in prostate cancer. Radiother Oncol, 2009, 93(2):234-240.
[14] Kato T, Tsukamoto E, Kuge Y, et al. Accumulation of[11C] acetate in normal prostate and benign prostatic hyperplasia:comparison with prostate cancer. Eur J Nucl Med Mol Imaging, 2002, 29(11):1492-1495.
[15] Ho CL, Yu SC, Yeung DW. 11C-acetate PET imaging in hepatocellular carcinoma and other liver masses. J Nucl Med, 2003, 44(2):213-221.
[16] Salem N, Kuang Y, Wang F, et al. PET imaging of hepatocellular carcinoma with 2-deoxy-2[18F]fluoro-D-glucose, 6-deoxy-6[18F] fluoro-D-glucose,[1-11C]-acetate and[N -methyl-11C]-choline. Q J Nucl Med Mol Imaging, 2009, 53(2):144-156.
[17] Park JW, Kim JH, Kim SK, et al. A prospective evaluation of 18F-FDG and 11C-acetate PET/CT for detection of primary and metastatic hepatocellular carcinoma. J Nucl Med, 2008,49(12):1912-1921.
[18] Cheung TT, Chan SC, Ho CL, et al. Can positron emission tomography with the dual tracers[11C] acetate and[18F] fludeoxyglucose predict microvascular invasion in hepatocellular carcinoma. Liver Transpl, 2011,17(10):1218-1225.
[19] Magini G, Farsad M, Frigerio M, et al. C-11 acetate does not enhance usefulness of F-18 FDG PET/CT in differentiating between focal nodular hyperplasia and hepatic adenoma. Clin Nucl Med, 2009, 34(10):659-665.
[20] Lhommel R, Annet L, Bol A, et al. PET scan with 11C-acetate for the imaging of liver masses:report of a false positive case. Eur J Nucl Med Mol Imaging, 2005, 32(5):629.
[21] Yamamoto Y, Nishiyama Y, Kimura N, et al. 11C-acetate PET in the evaluation of brain glioma:comparison with 11C-methionine and 18F-FDG-PET. Mol Imaging Biol, 2008,10(5):281-287.
[22] Liu RS, Chang CP, Guo WY, et al. l-11C-acetate versus 18F-FDG PET in detection of meningioma and monitoring the effect of gamma-knife radiosurgery. J Nucl Med, 2010, 51(6):883-891.
[23] Shreve P, Chiao PC, Humes HD, et al. Carbon-11-acetate PET imaging in renal disease. J Nucl Med, 1995, 36(9):1595-1601.
[24] Oyama N, Okazawa H, Kusukawa N, et al. 11C-Acetate PET imaging for renal cell carcinoma. Eur J Nucl Med Mol Imaging, 2009, 36(3):422-427.
[25] Kotzerke J, Linné C, Meinhardt M, et al.[1-11C] Acetate uptake is not increased in renal cell carcinoma. Eur J Nucl Med Mol Imaging, 2007, 34(6):884-888.
[26] Ho CL, Chen S, Ho KM, et al. 11C-acetate PET/CT in multicentric angiomyolipoma of the kidney. Clin Nucl Med, 2011, 36(5):407-408.
[27] Orevi M, Klein M, Mishani E, et al. 11C-acetate PET/CT in bladder urothelial carcinoma:intraindividual comparison with 11C-choline. Clin Nucl Med, 2012, 37(4):e67-72.
[28] Sun A, S?rensen J, Karlsson M, et al. 1-[11C]-acetate PET imaging in head and neck cancer-a comparison with 18F-FDG-PET:implications for staging and radiotherapy planning. Eur J Nucl Med Mol Imaging, 2007, 34(5):651-657.
[29] Sun A, Johansson S, Turesson I,et al. Imaging tumor perfusion and oxidative metabolism in patients with head-and-neck cancer using l-[11C]-acetate PET during radiotherapy:preliminary results. Int J Radiat Oncol Biol Phys, 2012, 82(2):554-560.
[30] Nomori H, Shibata H, Uno K, et al. 11C-Acetate can be used in place of 18F-fluorodeoxyglucose for positron emission tomography imaging of non-small cell lung cancer with higher sensitivity for well-differentiated adenocarcinoma. J Thorac Oncol, 2008, 3(12):1427-1432.
[31] Shibata H,Nomori H, Uno K, et al. 11C-acetate for positron emission tomography imaging of clinical stage IA lung adenocarcinoma:comparison with 18F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness. Ann Nucl Med, 2009, 23(7):609-616.
[32] Higashi K, Ueda Y, Matsunari I, et al. 11C-acetate PET imaging of lung cancer:comparison with 18F-FDG PET and 99mTc-MIBI SPET. Eur J Nucl Med Mol Imaging, 2004, 31(1):13-21.
[33] Kaji M, Nomori H, Watanabe K, et al. 11C-acetate and 18F-fluo-rodeoxyglucose positron emission tomography of pulmonary adeno-carcinoma. Ann Thorac Surg, 2007, 83(1):312-314.
[34] Lee SM, Kim TS, Lee JW, et al. Incidental finding of an 11C-acetate PET-positive multiple myeloma. Ann Nucl Med,2010, 24(1):41-44.
[35] Sakurai H, Kaji M, Suemasu K. Thymoma of the middle mediastinum:11C-acetate positron emission tomography imaging. Ann Thorac Surg, 2009, 87(4):1271-1274.
[36] Shreve PD, Gross MD. Imaging of the pancreas and related diseases with PET carbon-11-acetate. J Nucl Med, 1997, 38(8):1305-1310.

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备注/Memo

备注/Memo:
收稿日期:2012-10-07。
通讯作者:孙爱君,Email:sunaijun2006@126.com
更新日期/Last Update: 1900-01-01