[1]邹劲涛,余佩玲,董经纬,等.CD4+CD25+CD127-调节性T细胞在Graves病中的变化及临床意义[J].国际放射医学核医学杂志,2012,36(6):362-365.[doi:10.3760/cma.j.issn.1673-4114.2012.06.010]
 ZOU Jin-tao,YU Pei-ling,DONG Jing-wei,et al.Changes and clinical significance of CD4+CD25+CD127- regulatory T cells in Graves disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(6):362-365.[doi:10.3760/cma.j.issn.1673-4114.2012.06.010]
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CD4+CD25+CD127-调节性T细胞在Graves病中的变化及临床意义(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
36
期数:
2012年第6期
页码:
362-365
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Changes and clinical significance of CD4+CD25+CD127- regulatory T cells in Graves disease
作者:
邹劲涛1 余佩玲2 董经纬1 廖启洪3 刘东亮1 曾鸿毅1
1. 柳州市人民医院核医学科, 柳州 545006;
2. 柳州市人民医院医疗保健部, 柳州 545006;
3. 柳州市人民医院检验科, 柳州 545006
Author(s):
ZOU Jin-tao1 YU Pei-ling2 DONG Jing-wei1 LIAO Qi-hong3 LIU Dong-liang1 ZENG Hong-yi1
Department of Nuclear Medicine, Liuzhou People’s Hospital, Liuzhou 545006, China
关键词:
格雷夫斯病T淋巴细胞调节性抗原CD4抗原CD25抗原CD127
Keywords:
Graves diseaseT-lymphocytes regulatoryAntigens CD4Antigens CD25Antigens CD127
DOI:
10.3760/cma.j.issn.1673-4114.2012.06.010
摘要:
目的 通过观察Graves病患者外周血中CD4+CD25+CD127-调节性T细胞(Treg)数量的变化,探讨Graves病发生的免疫学机制。方法 采用流式细胞术检测90例Graves病患者和50名正常人外周血中CD4+CD25+CD127-Treg的比例,同时测定甲状腺功能指标及甲状腺自身抗体水平。采用t检验进行组间比较,采用线性相关分析法分析CD4+CD25+CD127-Treg与甲状腺功能指标的关系。结果 90例Graves病患者与50名正常人外周血中CD4+CD25+CD127-Treg的比例分别为1.39%±1.09%和4.59%±1.14%,两者间差异有统计学意义(t=16.4,P<0.01).CD4+CD25+CD127-Treg数量与促甲状腺激素受体抗体水平呈负相关(r=-0.24,P<0.05),与总三碘甲状腺原氨酸、总甲状腺素、游离三碘甲状腺原氨酸、游离甲状腺素、甲状腺球蛋白抗体、甲状腺微粒体抗体水平呈负相关(r=-0.62、-0.65、-0.56、-0.71、-0.50、-0.15,P均<0.01)。结论 Graves病患者CD4+CD25+CD127-Treg数量减少,且CD4+CD25+CD127-Treg数量与甲状腺功能指标及甲状腺自身抗体水平关系密切,提示CD4+CD25+CD127-Treg数量减少可能与Graves病的发病有关。CD4+CD25+CD127-可能是人CD4+T细胞中Treg的特异性标志物。
Abstract:
Objective To investigate the mechanism of Graves disease by observing the changes of CD4+CD25+CD127- regulatory T cells(Treg) population in the patients. Methods Flow cytometry was used to detect the proportion of CD4+CD25+CD127- Treg of CD4+ T cells in 90 Graves disease patients(Graves disease group) and 50 healthy adults(control group). Thyroid function and autoantibody levels were determined simultaneously. The t test was adopted for comparison between groups. The relationship between CD4+CD25+CD127- Treg and thyroid function was analyzed by linear correlation analysis. Results The percentages of CD4+CD25+CD127- Treg in Graves disease group and control group were 1.39%±1.09% and 4.59%±1.14% separately. There was significant difference between the two groups(t=16.4, P<0.01). There were negative correlation between CD4+CD25+CD127- Treg percentages and total triiodothyronine, total thyroxine, free triiodothyronine, free thyroxine and thyrotropin receptor antibody, thyroglobulin antibody, thyroid microsomal antibody(r=-0.62, -0.65, -0.56, -0.71, -0.50, -0.15, all P<0.01). Conclusions The reduction of CD4+CD25+CD127- Treg percentages in Graves disease group and close relations of CD4+CD25+CD127- Treg with thyroid function and thyroid autoantibody levels suggest that CD4+CD25+CD127- Treg decrease in the number may be associated with the onset of Graves disease. CD4+CD25+CD127- may be the specific marker of Treg.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2012-08-27。
基金项目:广西卫生厅立项科研项目(Z2009315);柳州市科技局科研项目(2010030715)
通讯作者:邹劲涛(Email:zoujint@126.com)
更新日期/Last Update: 1900-01-01