[1]杨立军,刘晓秋,李慷,等.磁场非热生物效应对肿瘤作用的研究与发展[J].国际放射医学核医学杂志,2013,37(6):374-377.[doi:10.3760/cma.j.issn.1673-4114.2013.06.012]
　YANG Li-jun,LIU Xiao-qiu,LI Kang,et al.Effect of electromagnetic radiation non-thermal bio-effects on tumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(6):374-377.[doi:10.3760/cma.j.issn.1673-4114.2013.06.012]
点击复制

磁场非热生物效应对肿瘤作用的研究与发展(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第6期
页码:
374-377
栏目:
综述
出版日期:
2013-11-25

文章信息/Info

Title:
Effect of electromagnetic radiation non-thermal bio-effects on tumor
作者:
杨立军1;  刘晓秋2;  李慷1;  佘义2
1. 天津大学材料学院材料科学及加工自动化系, 天津 300072;
2. 中国医学科学院放射医学研究所, 天津市分子核医学重点实验室, 天津 300192
Author(s):
YANG Li-jun1;  LIU Xiao-qiu2;  LI Kang1;  SHE Yi2
Department of Material Science and Process Automation, Material School of Tianjin University, Tianjin 300072, China
关键词:
肿瘤; 电磁场; 非热生物效应
Keywords:
Neoplasms; Electromagnetic field; Non-thermal bio-effects
DOI:
10.3760/cma.j.issn.1673-4114.2013.06.012
摘要:
该文论述了低频磁场对肿瘤细胞的选择性杀伤或生长抑制作用,以及存在的对肿瘤作用的频率窗效应和功率窗效应,指出了低频磁场在肿瘤放化疗过程中的增敏作用以及对多药耐药问题的改善作用,分析了其物理增敏的原因,并提出了对低频脉冲磁场参数规范的必要性,以减小因磁场差异而造成实验结果的不确定性.
Abstract:
This paper reveals the selective injury effect and suppressing growth effect of low frequency magnetic field on tumor cells.The effects occur in special ‘frequency windows’ and ‘power windows’.This paper also points out the sensitization from low frequency magnetic field occurs in radiotherapy and chemotherapy of tumor and the multi-drug resistance is decreased,analyzes the cause of physical sensitization.Finally,this paper presents that the low frequency pulse magnetic field should be normalized for the uncertainty from differences of pulse magnetic field.

参考文献/References:

[1] 陈万青,郑荣寿,张思维,等.2003~2007年中国癌症发病分析. 中国肿瘤,2012,2(3):161-170.
[2] 张思维,陈万青,郑荣寿,等.2003~2007年中国癌症死亡分析. 中国肿瘤,2012,2(3):171-178.
[3] 李虎军.败战癌症.财经,2008, 14:1-10.
[4] Cleary SF. A review of in vitro studies:low-frequency electromagnetic fields. Am Ind Hyg Assoc J, 1993, 54(4):178-185.
[5] De Mattei M, Gagliano N, Moscheni C, et al. Changes in polyamines, c-myc and c-fos gene expression in osteoblast-like cells exposed to pulsed electromagnetic fields. Bioelectromagnetics, 2005,26(3):207-214.
[6] Ikehara T, Park KH, Yamaguchi H, et al. Effects on Rb+ K+ uptake of HeLa cells in a high K+ medium of exposure to a switched 1.7 Tesla magnetic field. Bioelectromagnetics, 2000, 21(3):228-237.
[7] 张小云,张晓鄂.恒定强磁场对Hela细胞生长分裂的影响.科学通报,1989, 34(24):1901-1904.
[8] Zhang X, Zhang H, Zheng C, et al. Extremely low frequency (ELF) pulsed-gradient magnetic fields inhibit malignant tumour growth at different biological levels. Cell Biol Int, 2002, 26(7):599-603.
[9] 王晓杰,胡大为,张秀芹,等.脉冲强磁场对小鼠H22肝癌杀伤作用的影响.中华物理医学与康复杂志,2004, 26(10):600-602.
[10] 张沪生.一定参数的磁场在不同生物层次上抑制恶性肿瘤生长.生物磁学,2004,4(2):1-4.[ll] Yamaguchi S, Ogiue-Ikeda M, Sekino M, et al. Effects of pulsed magnetic stimulation on tumor development and immune functions in mice. Bioelectromagnetics, 2006, 27(1):64-72.
[12] Tofani S, Barone D, Cintorino M, et al. Static and ELF magnetic fields induce tumor growth inhibition and apoptosis. Bioelectromagnetics, 2001, 22(6):419-428.
[13] 表由晴.ハ゜ルズ磁界と抗癌剤との用による抗癌効果増強の試みに関する実験的研究.日外会誌,1988,第89回第8号:1155-1166.
[14] 刘晓秋,赵文正,赵阿津.γ射线与电磁辐射联合对白血病细胞的作用研究.辐射研究与辐射工艺学报,2002,20(1):77-80.
[15] Lagroye I, Poncy JL. The effect of 50 Hz electromagnetic fields on the formation of micronuclei in rodent cell lines exposed to gamma radiation. Int J Radiat Biol, 1997,72(2):249-254.
[16] Ruiz-Gómez MJ, de la Pe?a L, Prieto-Barcia MI, et al. Influence of 1 and 25 Hz, 1.5 mT magnetic fields on antitumor drug potency in a human adenocarcinoma cell line. Bioelectromagnetics, 2002, 23(8):578-585.
[17] Ding GR, Nakahara T, Hirose H, et al. Extremely low frequency magnetic fields and the promotion of H2O2-induced cell death in HL-60 cells. Int J Radial Biol, 2004, 80(4):317-324.
[18] Radeva M, Berg H. Differences in lethality between cancer cells and human lymphocytes caused by LF-electromagnetic fields. Bioelectromagnetics, 2004, 25(7):503-507.
[19] Hirata M, Kusuzaki K, Takeshita H, et al. Drug resistance modification using pulsing electromagnetic field stimulation for multidrug resistant mouse osteosarcoma cell line. Anticancer Res, 2001, 21(1A):317-320.
[20] Liang Y, Hannan CJ Jr, Chang BK, et al. Enhanced potency of daunorubicin against multidrug resistant subline KB-ChR-8-5-11 by a pulsed magnetic field. Anticancer Res, 1997, 17(30):2083-2088.
[21] 张翠宁,刘晓秋,韩英,等.脉冲磁场逆转乳腺癌细胞多药耐药性的作用研究.中国肿瘤临床,2008, 35(21):1241-1243.
[22] Schuderer J, Oesch W, Felber N, et al. In vitro exposure apparatus for ELF magnetic fields. Bioelectromagnetics, 2004, 25(8):582-591.
[23] Engstr?m S, Markov MS, McLean MJ, et al. Devices for gradient static magnetic field exposure. Bioelectromagnetics, 2005, 26(4):336-340.

相似文献/References:

[1]何燕,苏晋,郑晓霞,等.P-糖蛋白抑制剂在PET显像中的应用研究[J].国际放射医学核医学杂志,2016,40(1):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
　He Yan,Su Jin,ZhengXiaoxia,et al.Developing P-glycoprotein inhibitor marked by PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
[2]许飞,刘建军,黄钢,等.PET乏氧显像在预测肿瘤乏氧及指导临床治疗中的应用进展[J].国际放射医学核医学杂志,2016,40(1):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
　Xu Fei,Liu Jianjun,Huang Gang,et al.The application of hypoxia imaging with PET in predicting tumor hypoxia and guiding clinical therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
[3]陈顺军,程兵.肿瘤细胞凋亡核素显像分子探针研究进展[J].国际放射医学核医学杂志,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
　Chen Shunjun,Cheng Bing.Progress in molecular probes of radionuclide tumor apoptosis imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
[4]陈晓艳,张江虹,邵春林.STAT3与辐射敏感相关性的研究进展[J].国际放射医学核医学杂志,2016,40(3):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
　Chen Xiaoyan,Jianghong,Shao Chunlin.Research progresses of correlation between STAT3 and radiosensitivity[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
[5]赵舒怡,储小飞,樊赛军.血清肿瘤标志物与肿瘤放疗疗效评估的研究进展[J].国际放射医学核医学杂志,2015,39(5):427.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 018]
　zhao shuyi,chu xiaofei,fan saijun..progression of study on serum tumor markers in evaluation of tumor radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(6):427.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 018]
[6]赵徵鑫,翟贺争,张文艺,等.质子重离子治疗肿瘤的进展[J].国际放射医学核医学杂志,2016,40(5):384.[doi:10.3760/cma.j.issn.1673-4114.2016.05.010]
　Zhao Zhixin,Zhai Hezheng,Zhang Wenyi,et al.Development of proton heavy ion in tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):384.[doi:10.3760/cma.j.issn.1673-4114.2016.05.010]
[7]任佳忠,李永梅,刘岩,等.99Tcm-MDP骨显像胸部异常放射性摄取的原因分析[J].国际放射医学核医学杂志,2016,40(6):459.[doi:10.3760/cma.j.issn.1673-4114.2016.06.011]
　Jiazhong,Li Yongmei,Liu Yan,et al.Reasons for the abnormal 99Tcm-MDP uptake in the thoracic tissue on bone scintigraphy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):459.[doi:10.3760/cma.j.issn.1673-4114.2016.06.011]
[8]马彦云,张辉.磁共振体素内不相干运动扩散加权成像的原理及应用进展[J].国际放射医学核医学杂志,2016,40(6):469.[doi:10.3760/cma.j.issn.1673-4114.2016.06.013]
　Ma Yanyun,Zhang Hui.The basic principle and application progress of intravoxel incoherent motion imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):469.[doi:10.3760/cma.j.issn.1673-4114.2016.06.013]
[9]杨卫东,汪静.肿瘤核素靶向治疗新进展[J].国际放射医学核医学杂志,2015,39(1):19.[doi:10.3760/cma.j.issn.1673-4114.2015.01.006]
　Yang Weidong,Wang Jing.Advance progress of radionuclide target tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(6):19.[doi:10.3760/cma.j.issn.1673-4114.2015.01.006]
[10]徐金苹,袁德晓,张江虹,等.辐射诱导的外泌体在肿瘤细胞侵袭转移中的作用[J].国际放射医学核医学杂志,2015,39(2):144.[doi:10.3760/cma.j.issn.1673-4114.2015.02.009]
　Xu Jinping,Yuan Dexiao,Zhang Jianghong,et al.The role of radiation-induced exosomes in tumor invasion and metastasis[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(6):144.[doi:10.3760/cma.j.issn.1673-4114.2015.02.009]

备注/Memo

备注/Memo:
收稿日期:2013-01-18。
基金项目:天津市科技支撑计划重点项目(10ZCKFSF00200)
通讯作者:刘晓秋,Email:liuxiaoqiu@irm-cams.ac.cn
更新日期/Last Update: 1900-01-01