[1]王芹,刘强,孙元明,等.X射线交叉互补修复基因多态性与肿瘤[J].国际放射医学核医学杂志,2013,37(6):370-373.[doi:10.3760/cma.j.issn.1673-4114.2013.06.011]
 WANG Qin,LIU Qiang,SUN Yuan-ming,et al.X-ray repair cross complementing genes polymorphism and tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(6):370-373.[doi:10.3760/cma.j.issn.1673-4114.2013.06.011]
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X射线交叉互补修复基因多态性与肿瘤(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第6期
页码:
370-373
栏目:
综述
出版日期:
2013-11-25

文章信息/Info

Title:
X-ray repair cross complementing genes polymorphism and tumors
作者:
王芹 刘强 孙元明 樊赛军 樊飞跃
北京协和医学院中国医学科学院放射医学研究所, 天津市分子核医学重点实验室, 天津 300192
Author(s):
WANG Qin LIU Qiang SUN Yuan-ming FAN Sai-jun FAN Fei-yue
Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China
关键词:
DNA修复多态性单核苷酸肿瘤X射线交叉互补修复基因
Keywords:
DNA repairPolymorphismsingle nucleotideNeoplasmsX-ray repair cross complementing gene
DOI:
10.3760/cma.j.issn.1673-4114.2013.06.011
摘要:
DNA损伤是细胞最常见的损伤,DNA修复蛋白可以对DNA损伤进行修复,在维持生物体基因组的完整性和抑制肿瘤的发生中起着重要的作用.DNA损伤修复基因表达的正常与否与肿瘤的进展有关.该文对目前的研究热点——人类X射线交叉互补修复基因(XRCC)家族中XRCC1、XRCC2和Rad51基因多态性与肿瘤的关系进行了综述.
Abstract:
DNA repair protein can repair DNA damage of cells and play important roles in maintaining the integrity of the genetic information and suppressing the formation of tumor.The expression of DNA repair genes associates with the development of tumors.In this review,an overview of the relationship between XRCC1,XRCC2 and Rad51 polymorphism of X-ray repair cross complementing gene family and tumors was introduced.

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备注/Memo

备注/Memo:
收稿日期:2013-01-10。
基金项目:国家自然科学基金(30870583)
通讯作者:樊飞跃,Email:faithyfan@yahoo.com
更新日期/Last Update: 1900-01-01