[1]谭伟,让蔚清,周平坤.癌干细胞与肿瘤的放射抗性[J].国际放射医学核医学杂志,2013,37(3):177-180.[doi:10.3760/cma.j.issn.1673-4114.2013.03.012]
 TAN Wei,RANG Wei-qing,ZHOU Ping-kun.Cancer stem cell and its relevance to tumors resistance to radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(3):177-180.[doi:10.3760/cma.j.issn.1673-4114.2013.03.012]
点击复制

癌干细胞与肿瘤的放射抗性(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第3期
页码:
177-180
栏目:
综述
出版日期:
2013-05-25

文章信息/Info

Title:
Cancer stem cell and its relevance to tumors resistance to radiotherapy
作者:
谭伟1 让蔚清1 周平坤2
1. 421001 湖南衡阳, 南华大学公共卫生学院环境医学与放射卫生研究所;
2. 100850 北京, 军事医学科学院放射与辐射医学研究所
Author(s):
TAN Wei1 RANG Wei-qing1 ZHOU Ping-kun2
Institute of Environmental Medicine and Radiation Hygiene, College of Public Health, University of South China, Hengyang 421000, China
关键词:
肿瘤肿瘤干细胞放射抗性DNA修复
Keywords:
NeoplasmsCancer stem cellsRadioresistanceDNA repair
DOI:
10.3760/cma.j.issn.1673-4114.2013.03.012
摘要:
有关癌干细胞及其生物学特性研究信息的不断积累,推动了放射肿瘤生物学的发展。近年来的研究发现,癌于细胞和静止期癌细胞可能是导致肿瘤放射抗性增加和肿瘤放射治疗后复发的主要细胞学基础,有关这两种癌细胞亚群的放射敏感性及其机制的研究进展迅速,为提高肿瘤对放射治疗敏感性的措施研究提供了新的学术思路。该文将就癌细胞亚群的放射分子生物学特性,分析讨论肿瘤放射抗性的细胞学基础和相关分子机制。
Abstract:
The gradually accumulated information and knowledge regarding cancer stem cell or stem-like cancer cell greatly potentiated the research progression of radiation oncology and biology.In recent years,a series studies have uncovered that the cancer stem cell and cancer quiescent cell could be the major cells origin attributed to the radioresistance and recurrence of tumors in the course of radiotherapy.A rapid research progression has already been achieved respecting the radiosensitivity and related mechanisms of the se two subsets of cancer cells,and which provides an idea strategy for development of the measures targeting tumor radioresistance.This paper reviewed and discussed the cellular basis and molecular mechanism of the tumor radioresistance from the aspects of cancer cells subsets and the radiobiological characteristics.

参考文献/References:

[1] Sinclair WK,Morton HA. X-ray sensitivity during cell generation cycle of cultured chinese hamster cel1s. Radiat Res,1966,29(3):450-474.
[2] Ahsan A. Hiniker SM,Davis MA,et al. Role of cell cycle in epidermal growth factor receptor inhibitor-mediated radiosensitization. Cancer Res,2009,69(12):5108-5114.
[3] Vaupel P. Tumor microenvironmental physiology and its implcations for radiation oncology. Semin Radiat Oncol,2004,14(3):198-206.
[4] Kyle AH,Baker JH,Minch inton AI. Targeting quiescent tumor cells via oxygen and IGF-I supplementation. Cancer Res,2012,72(3):801-809.
[5] Blagosklonnv MV. Cell cycle arrest is not senescence. Aging (Albany NY),2011,3(2):94-101.
[6] Masunaga S,Matsumoto Y,Kashino G,et al. Significance of manipulating tumour hypoxia and radiation dose rate in terms of local tumour response and lung metastatic potential,referring to the response of quiescent cell populations. Br J Radiol,2010,83(993):776-784.
[7] Masunaga S,Hirayama R,Uzawa A,et al. Influence of manipulating hypoxia in solid tumors on the radiation dose-rate effect in vivo,with reference to that in the quiescent cell population. Jpn J Radiol,2010,28(2):132-142.
[8] Lagadec C,Vlashi E,Della Donna L,et al. Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment. Breast Cancer Res,2010,12(1):R13.
[9] Masunaga S,Nagasawa H,Liu Y,et al. Evaluation of the radiosensitivity of the oxygenated tumor cell frac tions in quiescent cell populations within solid tumors. Radiat Res,2010,174(4):459-466,.
[10] Rockwell S,Liu Y,Seow HA,et al. Preclinical evaluation of Laromustine for use in combination with radiation therapy in the treatment of solid tumors. Int J Radiat Biol,2012,88(3):277-285.
[11] Hanahan D,Weinberg RA. Hallmarks of cancer:the next generation. Cell,2011,144(5):646-674.
[12] Demidenko ZN,Zubova SG,Bukreeva El,et al. Rapamycin decelerates cellular senescence. Cell Cycle,2009,8(12):1888-1895.
[13] Demidenko ZN,Korotchkina LG,Gudkov AV,et al. Paradoxical suppression of cellular senescentre by p53. Proc Natl Acad Sci USA,2010,107(21):9660-9664.
[14] Leontieva OV,Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells,while consecutive reactivation of mTOK is associated with conversion to senescence. Aging(Albany N Y),2010,2(12):924-935.
[15] Ogawa K,Yoshioka Y,Isohashi F,et al. Radiotherapy targeting cancer stem cells:current views and future perspectives. Anticancer Res,2013,33(3):747-754.
[16] Chargari C,Moncharmont C,Lévy A,et al. Cancer stem cells,crorner-stone of radioresistance and perspectives for radiosensitization:glioblastoma as an example. Bull Cancer,2012,99(12):1153-1160.
[17] Yoon SK. The biology of cancer stem cells and its clinical implication in hepatocellular carcinoma. Gut Liver,2012,6(1):29-40.
[18] Li Y,Laterra J. Cancer stem cells:distinct entities or dynamically regulated phenotypes?. Cancer Res,2012,72(3):576-580.
[19] Lopez J. Poitevin A,Memloza-Martinez V,et al. Cancer-initiating cells derived from established cervical cell lines exhibit stem-cell markers and increased radioresistance. BMC Cancer,2012,12(1):e48.
[20] Piao LS. Hur W,Kim TK,et al. CD133+ liver crancer stem cells modulate radioresistance in human hepatocellular carcinoma. Cancer Lett,2012,315(2):129-137.
[21] Wang J,Wakeman TP,Lathia JD,et al. Notch promotes radioresistance of glioma stem cells. Stem Cells,2010,28(1):17-28.
[22] Kim Y,Kim KH,Lee J,et al. Wnt activation is implicated in glioblastoma radioresistance. Lah Invest,2012,92(3):466-473.
[23] Nguyen NP,Almeida FS,Chi A,et al. Molecular biology of breast cancer stem cells:potential clinical applications. Cancer Treat Rev,2010,36(6):485-491.
[24] Facchino S,Abdouh M,Chatoo W,et al. BMI1 confers radioresistance to normal and cancerous neural stem crells through recruitment of the DNA damage response machinery. J Neurosci,2010,30(30):10096-10111.
[25] Bao S,Wu Q,McLendon RE,et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature,2006,444(7120):756-760.
[26] Pajonk F,Vlashi E,McBride WH. Radiation resistance of cancer stem cells:the 4 R’s of radiobiology revisited. Stem Cells,2010,28(4):639-648.
[27] Ropolo M,Daga A,Griffero F,et al. Comparative analysis of DNA repair in stem and nonstem glioma cell cultures. Mol Cancer Res,2009,7(3):383-392.
[28] Wang WJ,W u SP,Liu JB,et al. M YC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cells. Cancer Res,2013,73(3):1219-1231.
[29] Diehn M,Cho RW,Lobo NA,et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature,2009,458(7239):780-783.
[30] Zhou PK,Sun WJ,Sui JL,et al. DNA double-strand breaks repair and prediction of radiosensitivity of tumor cells. Chinese Medical J,1997,110(9):672.
[31] Zhou PK,Sproston ARM,Marples B,et al. The radiosensitivity of human fibroblast cell lines correlates with the residual levels of DNA double-strand breaks. Radiother Oncol,1998,47(3):271-276.
[32] Facompre N,Nakagawa H,Herlyn M,et al. Stem-like cells and therapy resistance in squamous cell carcinomas. Adv Pharmacol,2012,65:235-265.
[33] 余子建,徐勤枝,周丽君,等. 肝癌组织DNA-PKcs过量表达及其靶向siRNA分子的抗增殖作用. 世界华人消化杂志,2007,15(36):3815-3821.
[34] Shang ZF,Huang B,Xu QZ,et al. Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated Chk2 phosphorylation in response to DNA damage. Cancer Research,2010,70(9):3657-3666.
[35] Lee SW,Cho KJ,Park JH,et al. Expressions of Ku70 and DNA-PKcs as prognostic indicators of local control in nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys,2005,62(5):1451-1457.
[36] López J,Poitevin A,Mendoza-Martínez V,et al. Cancer-initiating cells derived from established cervical cell lines exhibit stem-cell markers and increased radioresistance. BMC Cancer,2012,12:48.
[37] Will more E,Elliott SL,Mainou-Fowler T,et al. DNA-dependen tprotein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia. Clin Cancer Res,2008,14(12):3984-3992.
[38] Beskow C,Skikuniene J,Holgersson A,et al. Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs,Ku70 and Ku86. Br J Cancer,2009,101(5):816-821.
[39] An J,Xu QZ,Sui JL,et al. Silencing of DNA-PKcs alters the transcriptional profile of certain signal transduction genes related to proliferation and differentiation in HeLa cells. Int J Mol Med,2005,16(3):455-462.
[40] An J,Xu QZ,Sui JL,et al. Down-regulation of c-myc protein by siRNA-mediated silencing of DNA-PKcs in Hela cells. Int J Cancer,2005,117(4):531-537.
[41] Oliver L,Hue E,Séry Q,et al. Differentiation-related response to DNA breaks in human mesenchymal stem cells. Stem Cells,2012,31(4):800-807.
[42] Kim SY,Rhee JG,Song X,et al. Breast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells:role of ATM. PLoS One,2012,7(11):e50423.

相似文献/References:

[1]何燕,苏晋,郑晓霞,等.P-糖蛋白抑制剂在PET显像中的应用研究[J].国际放射医学核医学杂志,2016,40(1):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
 He Yan,Su Jin,ZhengXiaoxia,et al.Developing P-glycoprotein inhibitor marked by PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
[2]许飞,刘建军,黄钢,等.PET乏氧显像在预测肿瘤乏氧及指导临床治疗中的应用进展[J].国际放射医学核医学杂志,2016,40(1):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
 Xu Fei,Liu Jianjun,Huang Gang,et al.The application of hypoxia imaging with PET in predicting tumor hypoxia and guiding clinical therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
[3]陈顺军,程兵.肿瘤细胞凋亡核素显像分子探针研究进展[J].国际放射医学核医学杂志,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
 Chen Shunjun,Cheng Bing.Progress in molecular probes of radionuclide tumor apoptosis imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
[4]陈晓艳,张江虹,邵春林.STAT3与辐射敏感相关性的研究进展[J].国际放射医学核医学杂志,2016,40(3):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
 Chen Xiaoyan,Jianghong,Shao Chunlin.Research progresses of correlation between STAT3 and radiosensitivity[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
[5]赵舒怡,储小飞,樊赛军.血清肿瘤标志物与肿瘤放疗疗效评估的研究进展[J].国际放射医学核医学杂志,2015,39(5):427.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 018]
 zhao shuyi,chu xiaofei,fan saijun..progression of study on serum tumor markers in evaluation of tumor radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):427.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 018]
[6]储小飞,赵舒怡,樊赛军.肿瘤干细胞与辐射抗性的研究进展[J].国际放射医学核医学杂志,2015,39(5):431.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 019]
 chu xiaofei,zhao shuyi,fan saijun..advance progress of cancer stem cells and radioresistance[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):431.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 019]
[7]赵徵鑫,翟贺争,张文艺,等.质子重离子治疗肿瘤的进展[J].国际放射医学核医学杂志,2016,40(5):384.[doi:10.3760/cma.j.issn.1673-4114.2016.05.010]
 Zhao Zhixin,Zhai Hezheng,Zhang Wenyi,et al.Development of proton heavy ion in tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):384.[doi:10.3760/cma.j.issn.1673-4114.2016.05.010]
[8]任佳忠,李永梅,刘岩,等.99Tcm-MDP骨显像胸部异常放射性摄取的原因分析[J].国际放射医学核医学杂志,2016,40(6):459.[doi:10.3760/cma.j.issn.1673-4114.2016.06.011]
 Jiazhong,Li Yongmei,Liu Yan,et al.Reasons for the abnormal 99Tcm-MDP uptake in the thoracic tissue on bone scintigraphy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):459.[doi:10.3760/cma.j.issn.1673-4114.2016.06.011]
[9]马彦云,张辉.磁共振体素内不相干运动扩散加权成像的原理及应用进展[J].国际放射医学核医学杂志,2016,40(6):469.[doi:10.3760/cma.j.issn.1673-4114.2016.06.013]
 Ma Yanyun,Zhang Hui.The basic principle and application progress of intravoxel incoherent motion imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):469.[doi:10.3760/cma.j.issn.1673-4114.2016.06.013]
[10]杨卫东,汪静.肿瘤核素靶向治疗新进展[J].国际放射医学核医学杂志,2015,39(1):19.[doi:10.3760/cma.j.issn.1673-4114.2015.01.006]
 Yang Weidong,Wang Jing.Advance progress of radionuclide target tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):19.[doi:10.3760/cma.j.issn.1673-4114.2015.01.006]

备注/Memo

备注/Memo:
收稿日期:2013-04-08。
基金项目:国家自然科学杰出青年基金(30825011)
通讯作者:周平坤,Email:zhoupk@bmi.ac.cn
更新日期/Last Update: 1900-01-01