[1]李蕾,杨国仁.核医学在乳腺癌前哨淋巴结活检术中的方法学研究现状[J].国际放射医学核医学杂志,2013,37(3):181-185.[doi:10.3760/cma.j.issn.1673-4114.2013.03.013]
　LI Lei,YANG Guo-ren.Current status of methodology research on nuclear medicine on sentinel lymph node biopsy in breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(3):181-185.[doi:10.3760/cma.j.issn.1673-4114.2013.03.013]
点击复制

核医学在乳腺癌前哨淋巴结活检术中的方法学研究现状(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第3期
页码:
181-185
栏目:
综述
出版日期:
2013-05-25

文章信息/Info

Title:
Current status of methodology research on nuclear medicine on sentinel lymph node biopsy in breast cancer
作者:
李蕾;  杨国仁
250117, 济南大学, 山东省医学科学院, 山东省肿瘤医院核医学科
Author(s):
LI Lei;  YANG Guo-ren
Department of Nuclear Medicine, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, University of Jinan, Jinan 250117, China
关键词:
乳腺肿瘤; 前哨淋巴结活组织检查; 核医学
Keywords:
Breast neoplasms; Sentinel lymph node biopsy; Nuclear medicine
DOI:
10.3760/cma.j.issn.1673-4114.2013.03.013
摘要:
乳腺癌是女性最常见的恶性肿瘤之一,腋窝淋巴结清扫术一直被认为是乳腺癌外科治疗中最基本的手术方法。近年来发展起来的前哨淋巴结活检术因既能避免腋窝淋巴结清扫术引起的并发症,又能对乳腺癌进行准确地分期,具有操作简单、安全、准确率高、创伤小等优点,从而逐渐被国内外认可,已代替腋窝淋巴结清扫术成为治疗腋下淋巴结阴性患者的主要方法。在前哨淋巴结活检术中,核医学检查起了至关重要的作用,其中,放射性显像剂、注射技术、探测技术以及探测标准对乳腺癌腋下淋巴结和内乳淋巴结检测的准确率和假阴性率有着重要的影响,该文对近年来国内外关于核医学在乳腺癌前哨淋巴结活检术中的方法学研究现状进行综述。
Abstract:
Breast cancer is the most common malignancy of the female,and axillary lymph node dissection has been considered as the basic method in breast cancer surgery.Sentinel lymph node biopsy (SLNB) in recent years is accepted gradually both at home and abroad because it not only can avoid complications but also has the advantages of safe and simple operation,high accuracy,and slight trauma.It has taken the place of axillary lymph node dissection in the treatment of axillary node-negative patients.Nuclear medicine inspection has played a crucial role in SLNB,and radiotracers,injecting techniques,detecting methods and standards have great influence upon the accuracy and false-negative rate of axillary lymph nodes and internal mammary lymph nodes detection.In this review,the current methodology status of nuclear medicine is summarized on SLNB in breast cancer at home and abroad.

参考文献/References:

[1] Cody HS 3rd. Sentinel lymph node biopsy. London:Martin Dunitz Ltd, 2002:20-43.
[2] Nathanson SD, Anaya P, Karvelis KC, et al. Sentinel lymph node uptake of two different technetium-labeled radiocolloids. Ann Surg Oncol, 1997,4(2):104-110.
[3] 刘峰,王华,施常备. 前哨淋巴结显像剂的应用现状及发展. 现代肿瘤医学,2003,11(4):314-315.
[4] Harlow SP, Krag DN. Sentinel lymph node biopsy in breast cancer. Breast Dis, 2001, 12:43-45.
[5] Edreira MM, Colombo LL, Perez JH, et al. In vivo evaluation of three different 99mTc-labelled radiopharmaceuticals for sentinel lymph node identification. Nucl Med Conmmn, 2001, 22(5):499-504.
[6] Jakub JW, Cox CE, Pippas AW, et al. Controversial topics in breast lymphatic mapping. Semin Oncol, 2004, 31(3):324-332.
[7] 杨国仁,王永胜,张鹏,等. 99Tcm-SC显像联合蓝染法探测乳腺癌前哨淋巴结. 中华核医学杂志,2003,23(3):136-138.
[8] Reff ME, Carner K, Chambers KS, et al. Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20. Blood, 1994, 83(2):435-445.
[9] 王雪鹃,杨志,林保和,等. 前哨淋巴结显像剂99Tcm-IT-Ritux-imab的制备及其定位性能. 中华核医学杂志,2006,26(4):226-230.
[10] Phillips WT, Klipper R, Goins B. Use of 99mTc-labeled liposomes encapsulating blue dye for identification of sentinel lymph node. J Nucl Med, 2001, 42(3):446-451.
[11] 周敏,章英剑,程竞仪,等. 内乳前哨淋巴结99Tcm-硫胶体显像影响因素分析. 中华核医学杂志,2009,29(1):8-11.
[12] Harlow SP, Krag DN, Julian TB, et al. Prerandomization Surgical Training for the National Surgical Adjuvant Breast and Bowel Project(NSABP) B-32 trial:a randomized phase III clinical trial to compare sentinel node resection to conventional axillary dissection in clinically node-negative breast cancer. Ann Surg, 2005, 241(1):48-54.
[13] Mansel RE, Fallowfield L, Kissin M, et al. Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer:the ALMANAC Trial. J Natl Cancer Inst, 2006, 98(9):599-609.
[14] James TA, Edge SB. Sentinel lymph node in breast cancer. Curr Opin Obstet Gynecol, 2006, 18(1):53-58.
[15] Nieweg OE, Estourgie SH, van Rijk MC, et al. Rationale for superficial injection techniques in lymphatic mapping in breast cancer patients. J Surg Oncol, 2004, 87(4):153-156.
[16] Kinoshita T. Sentinel lymph node biopsy is feasible for breast cancer patients after neoadjuvant chemotherapy. Breast Cancer, 2007, 14(1):10-15.
[17] Mudun A, Sanli Y, Ozmen V, et al. Comparison of different injection sites of radionuclide for sentinel lymph node detection in breast cancer:single institution experience. Clin Nucl Med, 2008, 33(4):262-267.
[18] Rodier JF, Velten M, Wilt M, et al. Prospective multicentric randomized study comparing periareolar and peritumoral injection of radiotracer and blue dye for the detection of sentinel lymph node in breast sparing procedures:FRANSENODE trial. J Clin Oncol, 2007, 25(24):3664-3669.
[19] Noguchi M, Inokuchi M, Zen Y. Complement of peritumoral and subareolar injection in breast cancer sentinel lymph node biopsy. J Surg Oncol, 2009, 100(2):100-105.
[20] 杨余朋,郑刚,郑美珠,等. 乳腺癌前哨淋巴结解剖学定位及其临床意义的研究. 中华肿瘤防治杂志,2010,17(14):1100-1103.
[21] Lerman H, Metser U, Lievshitz G, et al. Lymphoscintigraphic sentinel node identification in patients with breast cancer:the role of SPECT-CT. Eur J Nucl Med Mol Imaging, 2006, 33(3):329-337.
[22] 杨国仁,张秀丽,孙晓蓉,等. FDG PET/CT联合99Tcm-SC前哨淋巴结显像诊断乳腺癌. 中华核医学杂志,2004,24(5):312.
[23] Paredes P, Vidal-Sicart S, Zanón G, et al. Radioguided occult lesion localization in breast cancer using an intraoperative portable gamma camera:first results. Eur J Nucl Med Mol Imaging, 2008, 35(2):230-235.
[24] Jakub JW, Cox CE, Pippas AW, etal. Controversial topics in breast lymphatic mapping. Semin Oncol, 2004, 31(3):324-332.
[25] Torrenga H, Meijer S, Fabry H, et al. Sentinel node biopsy in breast cancer patients:triple technique as a routine procedure. Ann Surg Oncol, 2004, 11(3 Suppl):S231-235.
[26] Uren RF, Howman-Giles R, Chung D, et al. Nuclear medicine aspects of melanoma and breast lymphatic, mapping. Semin Oncol, 2004, 31(3):338-348.
[27] Krag DN, Anderson SJ, Julian TB, et al. Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer:results from the NSABP B-32 randomised phase III trial. Lancet Oncol, 2007, 8(10):881-888.
[28] Dutta R, Kluftinger A, MacLeod M, et al. Revisiting the "10% rule" in breast cancer sentinel lymph node biopsy:an approach to minimize the number of sentinel lymph nodes removed. Am J Surg, 2012, 203(5):623-627.
[29] McCarter MD, Yeung H, Fey J, et al. The breast cancer patient with multiple sentinel nodes:when to stop?. J Am Coil Surg, 2001, 192(6):692-697.
[30] Low KS, Littlejohn DR. Optimal number of sentinel nodes after intradermal injection isotope and blue dye. ANZ J Surg, 2006, 76(6):472-475.
[31] National Comprehensive Cancer Network. NCCN clinical practice guidelines in Oncology:breast cancer[EB/OL].[2012-09-10]. http://www.neen.org/professionals/physician_gls/f_guidelines.asp.

相似文献/References:

[1]杨雷,袁卫红,王家平,等.99Tcm-MIBI显像与钼靶X线对乳腺癌诊断的比较研究[J].国际放射医学核医学杂志,2016,40(2):111.[doi:10.3760/cma.j.issn.1673-4114.2016.02.005]
　Yang Lei,Yuan Weihong,Wang Jiaping,et al.Diagnostic value of technetium 99Tcm sestamibi and X-ray mammography in breast cancer: a comparison study[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):111.[doi:10.3760/cma.j.issn.1673-4114.2016.02.005]
[2]马乐,张万春,李晓敏.乳腺癌前哨淋巴结核素显像新进展[J].国际放射医学核医学杂志,2016,40(2):145.[doi:10.3760/cma.j.issn.1673-4114.2016.02.012]
　Ma Le,Zhang Wanchun,Li Xiaomin.Evolution of radionuclide imaging of sentinel node lymphscintigraphy in breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):145.[doi:10.3760/cma.j.issn.1673-4114.2016.02.012]
[3]储小飞,赵舒怡,樊赛军.肿瘤干细胞与辐射抗性的研究进展[J].国际放射医学核医学杂志,2015,39(5):431.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 019]
　chu xiaofei,zhao shuyi,fan saijun..advance progress of cancer stem cells and radioresistance[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):431.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 019]
[4]陈伟君,孙达.99Tcm-MIBI显像在乳腺癌新辅助化疗中的应用价值[J].国际放射医学核医学杂志,2015,39(6):487.[doi:10.3760/cma.j.issn.1673-4114.2015.06.011]
　Chen Weijun,Sun Da.Clinical value of 99Tcm-MIBI imaging in neoadjuvant chemotherapy of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):487.[doi:10.3760/cma.j.issn.1673-4114.2015.06.011]
[5]胡鸿,唐刚华,聂大红.乳腺癌分子显像研究进展[J].国际放射医学核医学杂志,2015,39(1):91.[doi:10.3760/cma.j.issn.1673-4114.2015.01.019]
　Hu Hong,Tang Ganghua,Nie Dahong.Progress on molecular imaging of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):91.[doi:10.3760/cma.j.issn.1673-4114.2015.01.019]
[6]黄娟,颜剑豪,梁联保,等.注射钆剂后弥散加权成像对乳腺肿瘤诊断的影响[J].国际放射医学核医学杂志,2015,39(4):287.[doi:10.3760/cma.j.issn.1673-4114.2015.04.003]
　Huang Juan,Yan Jianhao,Liang Lianbao,et al.Evaluation of the diffusion-weighted imaging after contrast for the characterization of breast tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):287.[doi:10.3760/cma.j.issn.1673-4114.2015.04.003]
[7]李雯,冯彦林.18F-FDG PET/CT评估三阴性乳腺癌新辅助化疗疗效的研究进展[J].国际放射医学核医学杂志,2014,38(3):197.[doi:10.3760/cma.j.issn.1673-4114.2014.03.013]
　Li Wen,Feng Yanlin.Advances of assessment with 18F-FDG PET/CT in triple-negative breast cancer during neoadjuvant chemotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):197.[doi:10.3760/cma.j.issn.1673-4114.2014.03.013]
[8]殷丽娜,张旭霞,张俊香,等.Wnt/β-catenin信号通路——乳腺癌的潜在治疗靶点[J].国际放射医学核医学杂志,2014,38(4):252.[doi:10.3760/cma.j.issn.1673-4114.2014.04.011]
　Yin Lina,Zhang Xuxia,Zhang Junxiang,et al.The Wnt/β-catenin signaling pathway-a potential therapeutic target of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):252.[doi:10.3760/cma.j.issn.1673-4114.2014.04.011]
[9]刘超,邓智勇,刘鹏杰,等.89SrCL2与唑来膦酸联合治疗乳腺癌转移性骨肿瘤的疗效分析[J].国际放射医学核医学杂志,2014,38(5):300.[doi:10.3760/cma.j.issn.1673-4114.2014.05.006]
　Liu Chao,Deng Zhi-yong,Liu Peng-jie,et al.Analysis on the curative effect of combination therapy with zoledronic acid and 89SrCL2 on bone tumor with breast cancer metastasis[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):300.[doi:10.3760/cma.j.issn.1673-4114.2014.05.006]
[10]胡梦裳,章斌.PET/CT显像在乳腺癌疗效评价及预后中的作用[J].国际放射医学核医学杂志,2014,38(5):332.[doi:10.3760/cma.j.issn.1673-4114.2014.05.013]
　Hu Meng-shang,Zhang Bin.The role of PET/CT imaging in the evaluation of the efficacy and prognosis of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):332.[doi:10.3760/cma.j.issn.1673-4114.2014.05.013]
[11]俞丹,许林,洪明,等.99Tcm-硫胶体及其联合染色法对早期乳腺癌前哨淋巴结探测的比较[J].国际放射医学核医学杂志,2011,35(5):281.[doi:10.3760/cma.j.issn.1673-4114.2011.05.007]
　YU Dan,XU Lin,HONG Ming,et al.Comparison of radioactive sulfur colloid and combined methylene blue injection methods for detection of sentinel lymph node in early breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(3):281.[doi:10.3760/cma.j.issn.1673-4114.2011.05.007]

备注/Memo

备注/Memo:
收稿日期:2012-09-21。
基金项目:山东省自然科学基金(2012ZRC03041)
通讯作者:杨国仁,Email:guorenyang@yahoo.com.cn
更新日期/Last Update: 1900-01-01