[1]王胜军,杨卫东,赵小虎,等.18F-FDG PET/CT诊断多发癌的价值[J].国际放射医学核医学杂志,2013,37(2):96-99.[doi:10.3760/cma.j.issn.1673-4114.2013.02.009]
　WANG Sheng-jun,YANG Wei-dong,ZHAO Xiao-hu,et al.Value of 18F-FDG PET/CT in the diagnosis of multiple primary malignant neoplasms[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(2):96-99.[doi:10.3760/cma.j.issn.1673-4114.2013.02.009]
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18F-FDG PET/CT诊断多发癌的价值(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第2期
页码:
96-99
栏目:
论著
出版日期:
2013-03-25

文章信息/Info

Title:
Value of 18F-FDG PET/CT in the diagnosis of multiple primary malignant neoplasms
作者:
王胜军;  杨卫东;  赵小虎;  全志永;  易婧薇;  马晓伟;  李桂玉;  杨治平;  汪静
第四军医大学西京医院核医学科, 西安, 710032
Author(s):
WANG Sheng-jun;  YANG Wei-dong;  ZHAO Xiao-hu;  QUAN Zhi-yong;  YI Jing-wei;  MA Xiao-wei;  LI Gui-yu;  YANG Zhi-ping;  WANG Jing
Department of Nuclear Medicine, Xijing Hospital, the Fourth Military Medical University,Xi’an 710032, China
关键词:
肿瘤; 正电子发射断层显像术; 体层摄影术; X线计算机; 氟脱氧葡萄糖F18
Keywords:
Neoplasms; Positron-emission tomography; Tomography; X-ray computed; Flurodeoxy-glucose F18
DOI:
10.3760/cma.j.issn.1673-4114.2013.02.009
摘要:
目的 探讨18F-FDG PET/CT在多发癌诊断中的价值。方法 回顾性分析5822例疑似肿瘤患者,均行18F-FDG PET/CT全身检查,经过活检或手术证实为多发癌患者32例。以病理结果作为金标准,以PET平均标准化摄取值(SUVmax)≥2.5且CT上有形态学改变者作为PET/CT判断恶性肿瘤的标准,计算PET/CT诊断多发癌的灵敏度和准确率。结果 本组患者中多发癌的发生率为0.55%,其中,双发癌30例、三发癌2例,共66个原发灶。32例多发癌的66个原发灶的SUVmax的平均值为6.68±3.61.PET/CT诊断多发癌原发灶真阳性为58个,假阴性为8个。PET/CT诊断多发癌的灵敏度为87.9%,准确率为87.9%。结论 18F-FDG PET/CT全身检查诊断多发癌具有较大价值。
Abstract:
Objective To explore the value of 18F-FDG PET/CT in diagnosis of multiple primary malignant neoplasms.Methods Five thousand eight hundred and twenty-two patients with suspected tumors were retrospectively reviewed.All cases underwent 18F-FDG PET/CT and 32 patients were confirmed with multiple primary malignancies by biopsy or resection.Mean standardized uptake value (SUVmean) was calculated and SUVmean≥2.5 and abnormal morphological changes on CT were used as a standard to diagnose a malignant tumor.The sensitivity and accuracy of PET/CT in diagnosis of multiple primary maligant neoplasms were calculated.Results The incidence rate of multiple primary malignant neoplasms was 0.55%.Double primary malignant neoplasms were in 30 cases and triplicate primary malignant tumors were in 2 cases.There were 66 malignant tumor lesions.The average of SUVmean in 66 malignant tumor lesions was 6.68±3.61.The results of PET/CT were 58 true positive lesions and 8 false negative lesions.The sensitivity and accuracy of 18F-FDG PET/CT in diagnosis of multiple primary malignant neoplasms were 87.9% and 87.9% respectively.Conclusion 18F-FDG PET/CT whole body scan has an important value in the diagnosis of multiple primary malignant neoplasms.

参考文献/References:

[1] Demandante CG,Troyer DA,Miles TP.Multiple primary malignant neoplasms:case report and a comprehensive review of the literature.Am J Clin Oncol,2003,26(1):79-83.
[2] 王成峰,赵平,王靖,等.三个癌瘤以上的多原发恶性肿瘤.中华外科杂志,2002,40(12):902-904.
[3] Sun L,Wan Y,Lin Q,et al.Multiple primary malignant tumors of upper gastrointestinal tract:a novel role of,18F-FDG PET/CT.World J Gastroenterol,2010,16(31):3964-3969.
[4] Ha TK,Choi YY,Song SY,et al.F18-fluorodeoxyglucose-positron emission tomography and computed tomography is not accurate in preoperative staging of gastric cancer.J Korean Surg Soc,2011,81(2):104-110.
[5] Kim SY,Roh JL,Yeo NK,et al.Combined 18F-fluorodeoxyglucose-positron emission tomography and computed tomography as a primary screening method for detecting second primary cancers and distant metastases in patients with head and neck cancer.Ann Oncol,2007,18(10):1698-1703.

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备注/Memo

备注/Memo:
收稿日期:2012-09-11。
通讯作者:汪静,Email:wangjing@fmmu.edu.cn
更新日期/Last Update: 1900-01-01