[1]周晓靓,王浩,施培基,等.表皮生长因子受体-酪氨酸激酶肿瘤分子显像剂的研究进展[J].国际放射医学核医学杂志,2013,37(2):100-103.[doi:10.3760/cma.j.issn.1673-4114.2013.02.010]
 ZHOU Xiao-liang,WANG Hao,SHI Pei-ji,et al.The developme nt of epidermal growth factor receptor molecular imaging in cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(2):100-103.[doi:10.3760/cma.j.issn.1673-4114.2013.02.010]
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表皮生长因子受体-酪氨酸激酶肿瘤分子显像剂的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第2期
页码:
100-103
栏目:
论著
出版日期:
2013-03-25

文章信息/Info

Title:
The developme nt of epidermal growth factor receptor molecular imaging in cancer
作者:
周晓靓 王浩 施培基 刘鉴峰 孟爱民
中国医学科学院放射医学研究所, 天津市分子核医学重点实验室, 天津, 300192
Author(s):
ZHOU Xiao-liang WANG Hao SHI Pei-ji LIU Jian-feng MENG Ai-min
Tianjin Key Laboratory of Molecular Nulear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science, Tianjin 300192, China
关键词:
受体表皮生长因子正电子发射断层显像术体层摄影术发射型计算机单光子肿瘤分子显像剂
Keywords:
Recepterepithelial growth facterPositron-emission tomographyTomographyemission-computedsingle-photonCancer molecular imaging agent
DOI:
10.3760/cma.j.issn.1673-4114.2013.02.010
摘要:
目前治疗肿瘤最重要的分子靶向药物是以表皮生长因子受体(EGFR)为靶点的一类化合物,为了更好地实现靶向治疗效果,需要借助分子显像技术实现快速、定量地检测体内EGFR的分布及突变等情况。利用不同核素标记的分子探针实施PET或SPECT显像能够实现快速、无创地对患者进行遴选、疗效评价和监测EGFR靶向治疗,从而提高肿瘤治疗效果该文介绍了EGFR-酪氨酸激酶小分子显像剂及其最新的研究进展。
Abstract:
In vivo epidermal growth factor receptor(EGFR) targeted therapy has great potential for cancer diagnosis and the evaluation of curative effects.Enhancement of EGFR-targeted therapy needs a reliable quantitative molecular imaging method which eould enable monitoring of receptor drug binding and receptor occupancy in vivo,and identification of the mutation in EGFR.PET or SPECT is the most advanced molecular imaging technology of non-invasively selecting responders,predicting therapeutic outeome and monitoring EGFR-targeted treatment.This review analyzed the present situation and research progress of molecular imaging agents.

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备注/Memo

备注/Memo:
收稿日期:2012-11-12。
基金项目:中国医学科学院放射医学研究所发展基金(项目编号:SF1305)
通讯作者:孟爱民,Email:aiminmeng@irm-cams.ac.cn
更新日期/Last Update: 1900-01-01