[1]梁吉祥,柴树德,郑广钧,等.CT引导下植入125I粒子治疗非小细胞肺癌切除术后局部复发的疗效[J].国际放射医学核医学杂志,2011,35(3):181-185.[doi:10.3760/cma.j.issn.1673-4114.2011.03.012]
 LIANG Ji-xiang,CHAI Shu-de,ZHENG Guang-jun,et al.CT-guided percutaneous interstitial implantation of 125I for recurrent patients of postoperative non-small cell lung carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(3):181-185.[doi:10.3760/cma.j.issn.1673-4114.2011.03.012]
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CT引导下植入125I粒子治疗非小细胞肺癌切除术后局部复发的疗效(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
35
期数:
2011年第3期
页码:
181-185
栏目:
临床放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
CT-guided percutaneous interstitial implantation of 125I for recurrent patients of postoperative non-small cell lung carcinoma
作者:
梁吉祥 柴树德 郑广钧 杨景魁 霍小东
天津医科大学第二医院胸外科, 天津 300211
Author(s):
LIANG Ji-xiang CHAI Shu-de ZHENG Guang-jun YANG Jing-kui HUO Xiao-dong
Department of Thoracic Surgery, the Second Hospital of Tianjin Medical University, Tianjin 300211, China
关键词:
非小细胞肺碘放射性同位素近距离放射疗法体层摄影术X线计算机肿瘤复发局部
Keywords:
Carcinomanon-small-cell lungIodine radioisotopesBrachytherapyTomographyX-ray computedNeoplasm recurrencelocal
DOI:
10.3760/cma.j.issn.1673-4114.2011.03.012
摘要:
目的 探讨CT引导下经皮穿刺植入125粒子近距离内照射治疗非小细胞肺癌(NSCLC)切除术后局部复发的近期效果。方法 术前活检证实为NSCLC、术后局部复发的患者32例,处方剂量为90 Gy,通过CT引导经皮穿刺植入125I粒子。在治疗前和治疗后6个月,根据CT检查比较肿瘤体积,按国际标准判定疗效。中位随访24个月(6~72个月)。结果 植入粒子后,瘤体接受的平均照射剂量为153.7 Gy,D90为93.5 Gy。6个月后,完全缓解率+部分缓解率为90.6%,未发生与治疗相关的严重并发症。1年和2年的生存率分别为87%和73%,中位生存期为35个月。结论 在CT引导下,125I粒子植入治疗NSCLC术后局部复发安全、微创且有效。
Abstract:
Objective To evaluate the efficacy of percutaneous interstitial implantation with 125I seeds for recurrent patients of postoperative non-small cell lung carcinoma (NSCLC) guided by CT.Methods Thirty-two NLCLC patients were verified by biopsy pathology.Prescribed dose was 90 Gy.The percutaneous interstitial implantation of 125I seeds treatment was guided by CT.The carcinoma were scanned by CT and compared before and 6 months after treatment.Then judge the curative effect accerding to the curative standard put forward by World Health Organization.All the patients were folluwed-up for 6 to 72 months,mean 24 months.Results The mean radioactive dose of therapy group was 153.7 Gy,D90 was 93.5 Gy.Among the 32 follow-up cases,the complete and partial remission rate was 90.6%,and no major complications.One and two year survival rate were 87% and 73%,mean survival was 35 months.Conclusion Percutaneous interstitial implantation with 125I seeds for recurrent patients of postoperative NSCLC guided by CT is a valid,minimally invasive and efficient method.

参考文献/References:

[1] Paulson DL,Reisch JS.Long-term sunival after resection for bronchogenic carcinoma.Ann Surg,1976,184(3):324-332.
[2] Dautzenberg B,Arriagada R,Chammard AB,et al.A controlled study of postoperative radiotherapy for patients with completed resected nonsmall cell lung carcinoma.Groupe d’Etude et de Traitement desCancersBronchiques.Cancer,1999,86(2):265-273.
[3] Nesbitt JC,Putnam JB Jr,Walsh GL,et al.Survival in early-stage non-small lung cancer.Ann Thorac Surg,1995,60(2):466-472.
[4] 孙启和,孙彬,杨永青.术中125I粒子植入治疗肿瘤的临床应用[J].国际放射医学核医学杂志,2010(2):102-104.
[5] Colonias A,Betler J,Trombetta M,et al.Mature follow-up for high-risk stage I non-small-cell lung carcinoma treated with sublobar resection and intraoperative iodine-125 brachytherapy.Int J Radiat Oncol Biol Phys,2011,79(1):105-109.
[6] Mutyala S,Stewart A,Khan AJ,et al.Permanent iodine-125 interstitial planar seed brachytherapy for close or positive margins for thoracic malignancies.Int J Radiat Oncol Biol Phys,2010,76(4):1114-1120.
[7] Lee W,Daly BD,DiPetrillo TA,et al.Limited resection for nonsmall cell lung cancer,observed local control with implantation of I-125 brachytherapy seeds.Ann Thorac Surg,2003,75(1):237-243.
[8] 王锡明,李振家,武乐斌,等.CT引导下组织间置入125I粒子治疗肺癌的临床应用[J].中华放射学杂志,2005,39(5):490-492.
[9] 王俊杰,袁慧书,王皓,等.CT引导下放射性125I粒子组织间植入治疗肺癌[J].中国微创外科杂志,2008(2)119-121.
[10] Massard G,Lyons G,Wihlm JM,et al.Early and long-term results after completion pneumonectomy.Ann Thorac Surg,1995,59(1):196-200.
[11] 张灿斌,曹凤云.全肺切除治疗肺癌术后复发7例分析[J].中国误诊学杂志,2004,4(1):132-133.
[12] 赵辉,超福元,卢喜科,等.余肺切除治疗肺癌术后支气管残端复发癌14例报告[J].中国肿瘤临床,2000,27(12):994.
[13] 杜开齐,张锦贤,胡瑞行,等.肺癌术后复发的再手术治疗18例报告[J].武警医学,2002,13(2):93-94.
[14] 何枝生,匡裕康,曾来铎,等.肺癌术后余肺切除15例临床分析[J].实用癌症杂志,2007,22(6):662-663.
[15] Bradley JD,Hope A,El Naqa I,et al.A nomograrm to predict radiation pneumonitis,derived from a combined analysis of RTOG 9311and institutional data.Int J Radiat Oncol Biol Phys,2007,69(4):985-992.
[16] 李拥军,尹宜发,熊刚,等.肺癌放疗致放射性肺炎的多因素分析[J].实用肿瘤杂志,2006,21(4):302-305.
[17] 罗晓东,张新根,习永生,等.放射性肺损伤103例分析[J].江西医药,1998,33(4):205-207.
[18] 邓涤,周云峰,戈伟.肺癌放射治疗致放射性肺炎的临床分析[J].中国肿瘤临床,2002,29(12):866-868.
[19] 李而周,夏丽天,刘雅洁,等.引起放射性肺炎的相关因素及HRCT表现与预后的关系[J].中国医学影像学杂志,2003,11(5):327-329.
[20] 谢伟国,江莲,侯昕珩.急性放射性肺炎30例临床分析[J].临床肺科杂志,2009,14(11):1468-1469.
[21] 张矛,田琦.106例放射性肺炎相关因素分析[J].实用肿瘤学杂志,2005,19(4):290-291.
[22] 王俊杰,修典荣,冉维强.放射性粒子组织间近距离治疗肿瘤.2版.北京:北京医科大学出版社,2004:66-97.
[23] Johnson M,Colonias A,Parda D,et al.Dosimetric and technical nspects of intraoperative 1-125 brachytherapy for stage I non-small cell lung cancer.Phys Med Biol,2007,52(5):1237-1245.

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备注/Memo

备注/Memo:
收稿日期:2011-02-28。
通讯作者:柴树德(Email:xxwtj@sina.com)
更新日期/Last Update: 1900-01-01