[1]李亚军,张慧娟.放射性核素标记胆碱与18F-FDG PET肿瘤显像的对比研究[J].国际放射医学核医学杂志,2010,34(6):348-352.[doi:10.3760/cma.j.issn.1673-4114,2010.06.007]
 LI Ya-jun,ZHANG Hui-juan.Comparison choline with 18F-FDG PET in various tumors imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(6):348-352.[doi:10.3760/cma.j.issn.1673-4114,2010.06.007]
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放射性核素标记胆碱与18F-FDG PET肿瘤显像的对比研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第6期
页码:
348-352
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Comparison choline with 18F-FDG PET in various tumors imaging
作者:
李亚军 张慧娟
天津医科大学总医院放射科, 300052
Author(s):
LI Ya-jun ZHANG Hui-juan
Department of Radiology, General Hospital of Tianjin Medical University, Tianjin 300052, China
关键词:
胆碱碳放射性同位素氟脱氧葡萄糖F18正电子发射断层显像术肿瘤
Keywords:
CholineCarbon radioisotopesFlurodeoxyglucosePositron-emission tomographyNeoplasms
DOI:
10.3760/cma.j.issn.1673-4114,2010.06.007
摘要:
18F-FDG PET是目前临床上许多恶性肿瘤分期和再分期的首选检查方法,可明显提高恶性肿瘤的诊断准确性,对患者的治疗方案的选择产生了很大影响,而且在恶性肿瘤的疗效监测中也有很大价值。胆碱是保持细胞膜结构和功能完整性的重要成分,恶性肿瘤的胆碱代谢增高。11C-/18F-胴碱PET在临床上已用于许多恶性肿瘤的诊断及转移瘤的检出。该文回顾了18F-FDG和11C-/18F-胆碱PET在肿瘤显像中的应用价值,并比较了其优势和限度。
Abstract:
18F-FDG PET has become the preferred method of staging and restaging of many malignant neoplasms. Its application has increased diagnostic accuracy and exerted a considerable impact on the treatment of patients. 18F-FDG PET has also become extremely valuable in therapy efficacy monitoring of many malignant neoplasms. Choline is critical for cellular membrane structures and function. Choline metabolism increases in malignant neoplasms. 11C-/18F-choline PET has been used in diagnosis and detection of many malignant neoplasms and metastases. This paper reviews the value of 18F-FDG and 11C-/18F-choline PET in tumors imaging and compares their advantages and limitations.

参考文献/References:

[1] Fanti S,Nanni C,Lopci E,et al.Imaging with (11) Carbon labelled PET tracers.Nucl Med Commun,2010,31(7):613-616.
[2] Ohtani T,Kurihara H,Ishiuchi S,et al.Brain tumour imaging with carbon-11 choline:comparison with FDG PET and gadoliniumenhanced MR imaging.Eur J Nucl Med,2001,28(11):1664-1670.
[3] Huang Z,Zuo C,Guan Y,et al.Misdiagnoses of 11C-choline combined with 18F-FDG PET imaging in brain tumours.Nucl Med Commun,2008,29(4):354-358.
[4] Kwee SA,Ko JP,Jiang CS,et al.Solitary brain lesions enhancing at MR imaging:evaluation with fluorine 18 fluorocholine PET.Radiology,2007,244(2):557-565.
[5] Ninomiya H,Oriuchi N,Kahn N,et al.Diagnosis of tumor in the nasal cavity and paranasal sinuses with[11C]choline PET:comparative study with 2-[18F]fluoro-2-deoxy-D-gtucose (FDG) PET.Ann Nucl Med,2004,18(1):29-34.
[6] Khan N,Oriuchi N,Ninomiya H,et al.Positron emission tomographic imaging with 11C-choline in differential diagnosis of head and neck tumors:comparison with 18F-FDG PET.Ann Nucl Med,2004,18(5):409-417.
[7] Khan N,Oriuchi N,Zhang H,et al.A comparative study of11C-choline PET and[18F]fluorodeoxyglucose PET in the evaluation of lung cancer.Nucl Med Commun,2003,24(4):359-366.
[8] Hara T,Inagaki K,Kosaka N,et al.Sensitive detection of mediasti-nal lymph node metastasis of lung cancer with 11C-choline PET.J Nucl Med,2000,41(9):1507-1513.
[9] Hara T,Kosaka N,Suzuki T,et al.Uptake rates of 18F-fluorodeoxyglucose and 11C-choline in lung cancer and puhnonary tuberculosis:a positron emission tomography study.Chest,2003,124(3):893-901.
[10] Jager PL,Que TH,Vaalburg W,et al.Carbon-11 choline or FDGPET for staging of oesophageal cancer?.Eur J Nucl Med,2001,28(12):1845-1849.
[11] Kobori O,Kirihara Y,Kosaka N,et al.Positron emission tomography of esophageal eareirloma using (11) C-choline and (18) F-floorodeoxyglueose:a novel method of preoperative lymph node staging.Cancer,1999,86(9):1638-1648.
[12] Talbot JN,Gutman F,Fartoux L,et al.PET/CT in patients with hepatocellular carcinoma using[(18) F]fluorocholine:preliminary comparison with[(18) F]FDG PET/CT.Eur J Nucl Med Mol Imaging,2006,33(11):1285-1289.
[13] Yamamoto Y,Nishiyama Y,Kameyama R,et al.Detection of hepa-tocellular carcinoma using 11C-choline PET:comparison with 18F-FDG PET.J Nucl Med,2008,49(8):1245-1248.
[14] Shin DY,Han SW,Oh DY,et al.Prognostic implication of (18) F FDG-PET in patients with extrahepatic metastatic hepatocellular carcinoma undergoing systemic treatment,a retrospective cohort study[J/OL].Cancer Chemother Phannacol,2010[2010-09-25].http://www.springerlink,com/content/rv73818017052606/fulltext,pdf.
[15] Jadvar H,Quan V,Henderson RW,et al.[F-18]-Fluorodeoxyglucose PET and PET-CT in diagnostic imaging evaluation of locally recurrent and metastatic bladder transitional cell carcinoma.Int J Clin Oncol,2008,13(1):42-47.
[16] de Jong IJ,Pruim J,Elsinga PH,et al.Visualisation of bladder cancer using (11) C-choline PET:first clinical experience.Eur J Nucl Med Mol hnaging,2002,29(10):1283-1288.
[17] Picchio M,Treiber U,Beer A J,et al.Value of 11C-choline PET and contrast-enhanced CT for staging of bladder cancer:correlation with histopathologic findings.J Nucl Med,2006,47(6):938-944.
[18] Tolvanen T,Yli-Kerttula T,Ujula T,et al.Biodistribution and radiation dosimetry of[(11) C]choline:a comparison between rat and human data.EurJ Nucl Med Mol Imaging,2010,37(5):874-883.
[19] Price DT,Coleman RE,Liao RP,et al.Comparison of[18F]fluoro-choline and[18F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer.J Urol,2002,168(1):273-280.
[20] Scher B,Seitz M,Albinger W,et al.Value of 11C-choline PET and PET/CT in patients with suspected prostate cancer.Eur J Nucl Med Mol Imaging,2007,34(1):45-53.
[21] Picchio M,Messa C,Landoni C,et al.Value of[11C]cholinepositron emission tomography for re-staging prostate cancer:a comparison with[18F]fluorodeoxyglucose-positron emission tomo-graphy.J Urol,2003,169(4):1337-1340.
[22] Torizuka T,Kanno T,Futatsubashi M,et al.Imaging of gynecologic tumors:comparison of (11) C-choline PET with (18) F-FDG PET.J Nucl Med,2003,44(7):1051-1056.
[23] Maffione AM,Piva M,Tsamita CS,et al.Positron-emission tomography in gynaecologic malignancies.Arch Gynecol Obstet,2009,280(4):521-528.
[24] Sofne K,Tateishi U,Sawada M,et al.Role of carbon-11 choline PET/CT in the management of uterine carcinoma:initial experience.Ann Nucl Med,2009,23(3):235-243.
[25] Yanagawa T,Watanabe H,Inoue T,et al.Carbon-ll choline positron emission tomography in musculoskeletal tumors:comparison with fluorine-18 fluorodeoxyglucose positron emission tomography.J Comput Assist Tomogr,2003,27(2):175-182.
[26] Zhang H,Tian M,Oriuchi N,et al.11C-choline PET for the detection of bone and soft tissue tumours in comparison with FDG PET.Nucl Med Commun,2003,24(3):273-279.
[27] Tian M,Zhang H,Higuchi T,et al.Oncological diagnosis using (11) C-choline-positron emission tomography in comparison with 2-deoxy-2-[(18) F]fluoro-D-glucose-positron emission tomography.Mol Imaging Biol,2004,6(3):172-179.
[28] Tian M,Zhang H,Oriuchi N,et al.Comparison of 11C-choline PET and FDG PET for the differential diagnosis of malignant tumors.EurJ Nucl Med Mol Imaging,2004,31(8):1064-1072.

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备注/Memo

备注/Memo:
收稿日期:2010-09-30。
通讯作者:李亚军(E-mail:liyj002@163.com)
更新日期/Last Update: 1900-01-01