[1]李亚军,白人驹,高硕.PET在前列腺癌中的应用[J].国际放射医学核医学杂志,2006,30(5):283-286.
 LI Ya-jun,BAI Ren-ju,GAO Shuo.The applying of PET imaging in prostate cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(5):283-286.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第5期
页码:
283-286
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The applying of PET imaging in prostate cancer
作者:
李亚军 白人驹 高硕
300052 天津, 天津医科大学总医院PET-CT中心
Author(s):
LI Ya-jun BAI Ren-ju GAO Shuo
PET-CT Center, General Hospital of Tianjin Medical University, Tianjin 300052, China
关键词:
前列腺肿瘤体层摄影术发射型计算机18F-氟脱氧葡萄糖胆碱
Keywords:
Prostatic neoplasmsTomography emission-computed18F-fluorodeoxyglucoseCholine
分类号:
R817.4
摘要:
前列腺癌是老年男性最常见的恶性肿瘤之一,PET在其早期诊断和准确分期方面具有重要价值。18F-氟代脱氧葡萄糖(18F-FDG)PET对前列腺癌的检出并不敏感,也不能可靠进行淋巴结分期,但18F-FDG摄取与疾病进展程度相关。11C-胆碱PET诊断前列腺癌的准确率高,在淋巴结及骨转移的检出方面也明显优于18F-FDGPET,但其半衰期短而限制了临床应用。18F-胆碱的肿瘤摄取与11C-胆碱相似,但在泌尿系统排泄较高。其他示踪剂如11C-乙酸、11C-甲硫氨酸、18F标记的雄激素等在前列腺癌的诊断、分期及疗效评价方面也具有一定价值。
Abstract:
Prostate cancer is one of the most common malignancies in old men, positron emission tomography is very valuable in early diagnosing and accurately staging of prostate cancer. 18F-fluorodeoxyglucose (18F-FDG)PET is not sensitive in detection and reliable on staging of prostate cancer, but the uptake of 18F-FDG correlates with the stage of prostate cancer. 11C-choline PET is accurate in diagnosis of prostate cancer, and it is superior to 18F-FDG PET in detection of metastases in lymph nodes and bone. But its short half-life limits the clinic applying in prostate cancer. The uptake of 18F-choline in prostate cancer is similar to 11C-choline, but its excretion in urinary system is much higher than 11C-choline. The other tracers such as 11C-acetate, 11C-methionine and 16β-18F-fluoro-5α-dihydrotestosterone are also valuable in diagnosing, staging and evaluating the effect of treatment of prostate cancer.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2005-11-28。
通讯作者:李亚军,E-mail:liyj002@163.com
更新日期/Last Update: 1900-01-01