[1]赵雷,杨雁,孙华.自动化固相萃取法合成11C-乙酸盐的影响因素[J].国际放射医学核医学杂志,2015,39(3):224-227,234.[doi:10.3760/cma.j.issn.1673-4114.2015.03.008]
　Zhao Lei,Yang Yan,Sun Hua.Influential factors of solid-phase extraction method to automate the synthesis of 11C-acetate[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):224-227,234.[doi:10.3760/cma.j.issn.1673-4114.2015.03.008]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第3期
页码:
224-227,234
栏目:
出版日期:
2015-05-25

文章信息/Info

Title:
Influential factors of solid-phase extraction method to automate the synthesis of 11C-acetate
作者:
赵雷1;  杨雁2;  孙华1
1. 昆明医科大学第三附属医院, 云南省肿瘤医院PET/CT中心, 昆明, 650118;
2. 昆明医科大学海源学院, 昆明, 650106
Author(s):
Zhao Lei1;  Yang Yan2;  Sun Hua1
Center of PET/CT, the 3rd Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, China
关键词:
碳放射性同位素; 乙酸盐类; 固相萃取法; 自动化合成; 影响因素
Keywords:
Carbon radioisotopes; Acetates; Solid phase extraction; Automated synthesis; Influential factors
DOI:
10.3760/cma.j.issn.1673-4114.2015.03.008
摘要:
目的 探讨采用国产模块自动化固相萃取法合成11C-乙酸盐的影响因素。方法 通过调节11C-乙酸盐合成过程中加速器靶内11CO2释放速度、捕获环释放11CO2时间、甲基溴化镁/四氢呋喃(CH3MgBr/THF)浓度及用量、氮气气流、气压及合成体系中水等参数,研究这些因素对11C-乙酸盐合成效率的影响,从而找到最优化的合成条件。结果 经过18批次的条件优化实验后,11C-乙酸盐的合成效率为(53.7±3.6)%,放化纯度>99%。结论 CH3MgBr/THF浓度及用量和氮气气流、气压是影响11C-乙酸盐合成效率的主要因素。
Abstract:
Objective To discuss the factors that affect the synthesis of 11C-acetate via a domestic automated solid-phase extraction method.Methods The synthesis efficiency of 11C-acetate was influenced by the release rate of 11CO2 from the cyclotron target,the release time of 11CO2 by the capture ring,the concentration and volume of tetrahydrofuran (THF) with CH3MgBr,nitrogen current rate and pressure,water in the synthesis system.Thus,these parameters were optimized.Results After performing 18 runs of the conditional parallel experiment,the synthesis efficiency of 11C-acetate was increased to (53.7±3.6)%,and the radiochemical purity was more than 99%.Conclusion The main factors that affect the efficiency of 11C-acetate synthesis were the concentration and volume of CH3MgBr/THF,the current rate of nitrogen,and the pressure of nitrogen.

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备注/Memo

备注/Memo:
收稿日期:2014-10-11。
通讯作者:孙华,Email:petct163@163.com
更新日期/Last Update: 1900-01-01