[1]游洋,郭海卓,金顺子.微小RNA在电离辐射和肿瘤中的作用[J].国际放射医学核医学杂志,2009,33(4):243-245.[doi:10.3760/cma.j.issn.1673-4114.2009.04.016]
　YOU Yang,GUO Hai-zhuo,JING Shun-zi.The role of microRNA in tumor and ionizing radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(4):243-245.[doi:10.3760/cma.j.issn.1673-4114.2009.04.016]
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微小RNA在电离辐射和肿瘤中的作用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第4期
页码:
243-245
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
The role of microRNA in tumor and ionizing radiation
作者:
游洋1;  郭海卓2;  金顺子2
1. 吉林大学, 长春, 130021;
2. 吉林大学公共卫生学院卫生部放射生物学重点实验室, 长春, 130021
Author(s):
YOU Yang1;  GUO Hai-zhuo2;  JING Shun-zi2
1. Clinical Medicinet Jilin University, Changchun 130021, China;
2. Key Laboratory of Radiobiology, Ministry of Health, Jilin University, Changckun 130021, China
关键词:
微RNAs; 肿瘤; 辐射效应
Keywords:
MicroRNAs; Neoplasms; Radiation effects
DOI:
10.3760/cma.j.issn.1673-4114.2009.04.016
摘要:
MicroRNA(miRNA)是一类含21~25个核苷酸长度的单链小分子RNA,其在细胞生长和发育过程的调节中起到了多重作用,miRNA的突变或异位表达与多种肿瘤相关。电离辐射可以诱导miRNA的改变,从而产生致癌或抑癌效果,而且辐射诱导的miRNA表达变化还显示出细胞特异性和性别特异性。
Abstract:
MicroRNA (miRNA) are noncoding RNA of 21~25 nucleotides that act as posttranscriptional regulators of gene expression, it plays a multiple role in the regulation of cell growth and development. miRNA mutation or ectopia expression is associated with a variety of tumor. Ionizing radiation which has a carcinogenic or tumor suppressive effect induces changes in miRNA, miRNA expression changes induced by radiation are also cell-specific and gender-specific.

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备注/Memo

备注/Memo:
收稿日期:2009-01-11。
基金项目:国家自然科学基金(30870584)
通讯作者:金顺子,E-mail:ghunzij@yahoo.com.cn
更新日期/Last Update: 1900-01-01