[1]高志清,刘永学.G蛋白偶联受体与辐射关系的研究进展[J].国际放射医学核医学杂志,2009,33(4):246-248.[doi:10.3760/cma.j.issn.1673-4114.2009.04.017]
 GAO Zhi-qing,LIU Yong-xue.Advances on the relation between G protein-coupled receptors and radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(4):246-248.[doi:10.3760/cma.j.issn.1673-4114.2009.04.017]
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G蛋白偶联受体与辐射关系的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第4期
页码:
246-248
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
Advances on the relation between G protein-coupled receptors and radiation
作者:
高志清 刘永学
军事医学科学院放射与辐射医学研究所药理毒理研究室, 北京, 100850
Author(s):
GAO Zhi-qing LIU Yong-xue
Department ofpharmacology and Toxicology, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
关键词:
GTP结合蛋白类受体G蛋白偶联辐射损伤实验性
Keywords:
GTP-binding proteinReceptorsG protein-coupledRadiation injuriesexperimental
DOI:
10.3760/cma.j.issn.1673-4114.2009.04.017
摘要:
G蛋白偶联受体(GPCR)是一类细胞表面受体大家族,通过G蛋白介导其细胞作用,在介导细胞间信号转导的过程中起着十分重要的作用。研究发现,G蛋白和GPCR与辐射损伤关系密切,这些研究为充分认识辐射损伤机制及提高防治水平提供了新的观点。
Abstract:
G protein-coupled receptors (GPCR) are a large protein family of transmembrane receptors that mediate cells responding to extracellular signals through G proteins. They play a key role in intercellular signal transduction. Recent studies show that G protein and GPCR are closely related to radiation damage.This study provides a new perspective for fully understanding radiation damage mechanism and improving the prevention and treatment for it.

参考文献/References:

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[6] Kim SY,Seo M,Oh JM,et al.Inhibition of gamma ray-induced apoptosis by stimulatory heterotrimeric GTP binding protein involves Bcl-xL down-regulation in SH-SY5Y human neuroblas-toma cells.Exp Mol Med,2007,39(5):5S3-593.
[7] Houchen CW,Sturmoski MA,Anant S,et al.Prosurvival and antiapoptotic effects of PGE2 in radiation injuiy are mediated by EP2 receptor in intestine.Am J Physiol Gastrointest Liver Physiol,2003,284(3):G490-G498.
[8] Tokuda N,Hamasaki K,Mizutani N,et al.Expression of PAC1 receptor in rat thymus after irradiation.Regul Pept,2004,123(1-3):167-172.
[9] Chen NJ,Mirtsos C,Suh D.C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a.Nature,2007,446(7132):203-207.
[10] Chaudhry MA.Analysis of gene expression in normal and cancer cells exposed to gammar-radiation.J Biomed Biotechnol,2008,2008:541678.

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备注/Memo

备注/Memo:
收稿日期:2009-03-27。
基金项目:军队医药卫生"十一五"基金(06MA314)
通讯作者:刘永学,E-mail:liuyx@nic.bmi.ac.cn
更新日期/Last Update: 1900-01-01