[1]杨丽平,赵敬湘,裴雪涛.生物发光成像的特点及应用[J].国际放射医学核医学杂志,2009,33(4):249-252.[doi:10.3760/cma.j.issn.1673-4114.2009.04.018]
 YANG Li-ping,ZHAO Jing-xiang,PEI Xue-tao.Bioluminescence imaging characteristics and application[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(4):249-252.[doi:10.3760/cma.j.issn.1673-4114.2009.04.018]
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生物发光成像的特点及应用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第4期
页码:
249-252
栏目:
技术与方法
出版日期:
1900-01-01

文章信息/Info

Title:
Bioluminescence imaging characteristics and application
作者:
杨丽平1 赵敬湘2 裴雪涛2
1. 北京军区总医院263临床部神经内科, 北京, 101149;
2. 中国人民解放军军事医学科学院输血研究所干细胞生物学研究室, 北京, 100850
Author(s):
YANG Li-ping1 ZHAO Jing-xiang2 PEI Xue-tao2
1. Department of Neurology, NO. 263 Hospital, Beijing 101149, China;
2. Department of Stem Cell and Regenerative Medsine, Beijing Institute of Transfusion Medsine, Beijing 100850, China
关键词:
体层摄影术光学荧光素酶类肿瘤干细胞
Keywords:
TomographyopticalFluoresceinsNeoplasmsStem cells
DOI:
10.3760/cma.j.issn.1673-4114.2009.04.018
摘要:
生物发光成像(BLI)是通过荧光素酶基因标记细胞或DNA,在ATP及氧气存在条件下,催化荧光素的氧化反应而发光,从而能够直接监控活体内的细胞活动和基因行为。该文通过比较BLI与MRI,PET、放射成像的异同,以及BLI在肿瘤、干细胞和免疫细胞运输、细胞凋亡等方面的应用,为更好地推广BLI的应用提供依据。
Abstract:
Bioluminescence imaging (BLI) by luciferase gene marked cells or DNA, in the presence of ATP and oxygen, catalytic oxidation reaction of fluorescein luminescence. So that it can directly monitor in vivo cell activity and gene behavior. In this paper, by comparing the BLI and MRI, PET, radiography of the similarities and differences, as well as about their cancer, stem cells and immune cells transportation apoptosis and other aspects of the application, in order to better provide the basis for promoting the application of BLI.

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备注/Memo

备注/Memo:
收稿日期:2009-04-22。
基金项目:国家重点基础研究发展规划(973计划)(2005CB522702);国家高技术研究发展计划(863计划)(2006AA2A107)
通讯作者:裴雪涛,E-mail:peixt@nic.ac.cn
更新日期/Last Update: 1900-01-01