[1]李天然,田嘉禾.小动物PET及PET-CT及其在分子影像学中的应用[J].国际放射医学核医学杂志,2008,32(1):1-4.
 LI Tian-ran,TIAN Jia-he.Small animal PET and PET-CT its application in molecular imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(1):1-4.
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小动物PET及PET-CT及其在分子影像学中的应用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第1期
页码:
1-4
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Small animal PET and PET-CT its application in molecular imaging
作者:
李天然 田嘉禾
100853 北京, 解放军总医院核医学科
Author(s):
LI Tian-ran TIAN Jia-he
Department of Nuclear Medicine, General Hospital ofPLA, Beijing 100853, China
关键词:
体层摄影术发射型计算机体层摄影术X线计算机模型小动物分子诊断技术
Keywords:
Tomographyemission-computedTomographyX-ray computedModelssmall animalMolecular diagnostic technique
分类号:
R817.4;R814.42
摘要:
阐述小动物PET及PET-CT技术特点及在分子影像学中的应用。小动物PET及PET-CT采用多项新技术,分辨率明显提高,结合小动物CT实现了图像融合。小动物PET及PET-CT实现了在活体上非侵入性分子水平显像,是研究分子影像的尖端设备。
Abstract:
The review article introduce molecular imaging equipment small animal PET and PET-CT’s philosophy and technique feature, small animal PET and PET-CT apply many new techniques and images resolution has obviously raising, as same time, small animal PET and small animal CT may come true image fusion, small animal PET and PET-CT permit us to engage molecular level imaging in vivo without invading, so small animal PET and PET-CT are good tool in medical molecular imaging.

参考文献/References:

[1] Myers R. The biological application of small animal PET imaging[J]. Nucl Med Biol, 2001, 28(3):585-593.
[2] Jeavons AP. Small-animal PET cameras[J]. J Nucl Med, 2000, 41(8):1442-1443.
[3] Myers R, Hume S. Small animal PET[J]. Eur Neuropsychopharm, 2002, 12(6):545-555.
[4] 周伟,尹端沚,汪勇先.小动物PET[J].核技术,2006,29(3):207-213.
[5] Badea C, Hedlund LW, Johnson GA. Micro-CT with respiratory and cardiac gating[J]. Med Phys, 2004, 31(12):3324-3329.
[6] Henning T, Weber AW, Bauer JS, et al. Imaging characteristics of DHOG, a hepatobiliary contrast agent for preclinical micro CT in mice[J]. Acad Radiol, 2008, 15(3):342-349.
[7] 赵静.2002年RSNA科学论文选刊.中国医疗器械杂志[J],2003,27(4):231.
[8] Duvall CL, Taylor WR, Weiss D, et al. Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury[J]. Am J Physiol Heart Circ Physiol, 2004, 287(1):H302-H310.
[9] Liang H, Yang Y, Yang K, et al. A micro PET/CT system for in vivo small animal imaging[J]. Phys Med Biol, 2007, 52(13):3881-3894.
[10] Cai W, Zhang X, Wu Y, et al. A thiol-reactive 18F-labeling agent, N-[2(4-18F-Fluorobenzamido)Ethyl]maleimide, and synthesis of RGD peptide-based tracer for PET imaging of αvβ3 integrin expression[J]. Nucl Med, 2006, 47(7):1172-1180.
[11] Wang H, Cai W, Chen K, et al. A new PET tracer specific for vascular endothelial growth factor receptor2[J]. Eur J Nucl Med Mol Imaging, 2007, 34(12):2001-2010.
[12] Shu CJ, Guo S, Kim YJ,et al. Visualization of a primary anti-tumor immune response by positron emission tomography[J]. Proc Natl Acad Sci USA, 2005,102(48):17412-17417.
[13] Bérard V, Rousseau JA, Cadorette J, et al. Dynamic imaging of transient metabolic processes by small-animal PET for the evaluation of photosensitizers in photodynamic therapy of cancer[J]. J Nucl Med, 2006, 47(7):1119-1126.
[14] 李前伟.肿瘤整合素αvβ3受体显像的研究现状[J].国外医学·放射医学核医学分册,2003,27(5):198-200.
[15] Chen X, Tohme M, Park R, et al. Micro-PET imaging of alphavbeta3-integrin expression with 18F-labeled dimeric RGD peptide[J]. Mol Imaging, 2004, 3(2):96-104.
[16] Wu Z, Li ZB, Chen K, et al. microPET of tumor integrin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4)[J]. J Nucl Med, 2007, 48(9):1536-1544.
[17] Zhang X, Cai W, Cao F, et al. 18F-Labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer[J]. J Nucl Med, 2006, 47(3):492-501.
[18] Reshef A, Shirvan A, Grimberg H, et al. Novel molecular imaging of cell death in experimental cerebral stroke[J]. Brain Res, 2007, 1144(4):156-164.
[19] Aloya R, Shirvan A, Grimberg H, et al.Molecular imaging of cell death in vivo by a novel small molecule probe[J]. Apoptosis, 2006, 11(12):2089-2101.
[20] Weissleder R. Molecular imaging in cancer. Science, 2006, 312(5777):1168-1171.
[21] 田嘉禾.非FDG PET肿瘤显像技术[J].中华核医学杂志,2006,26(1):5-7.

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备注/Memo

备注/Memo:
收稿日期:2007-05-28。
通讯作者:田嘉禾,E-mail:tianjh@aina.vip.com.cn
更新日期/Last Update: 1900-01-01