[1]林向飞,骆丹.MDM2基因与肿瘤放射生物效应[J].国际放射医学核医学杂志,2007,31(2):118-121.
 LIN Xiangfei,LUO Dan.MDM2 gene and radiobiological effect in tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(2):118-121.
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MDM2基因与肿瘤放射生物效应(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第2期
页码:
118-121
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
MDM2 gene and radiobiological effect in tumors
作者:
林向飞 骆丹
210029 南京, 南京医科大学第一附属医院江苏省人民医院皮肤科
Author(s):
LIN Xiangfei LUO Dan
Department of Dermatology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
关键词:
基因MDM2基因p53辐射效应基因表达调控肿瘤紫外线
Keywords:
MDM2 genep53 geneRadiation effectsGene expression regulationNeoplasms
分类号:
Q345+.2
摘要:
鼠双微体2(MDM2)基因是电离和紫外线辐射反应中的关键组分,MDM2表达水平决定辐射诱导的抑癌基因p53活性增加程度。MDM2可以限制p53的凋亡功能,是许多类型细胞的存活因子。另外,DNA损伤诱导MDM2的表达,一般认为高水平的MDM2蛋白可以缩短辐射后p53建立的细胞周期阻滞。MDM2表达的增加似乎可以保证存活细胞中p53的活性回复到较低的基础水平。MDM2水平的降低增加了细胞对电离辐射的敏感性。因此,MDM2是介入治疗的潜在靶点。
Abstract:
Murine double minute 2 (MDM2) gene is a eritieal eomponent of the responses to both ionizing and UV radiation. The level of MDM2 expression determines the extent to whieh radiation induees an inerease in the aetivity of the p53 tumor suppressor. MDM2 aets as a survival faetor in many eell types by limiting the apoptotie funetion of p53. In addition, expression of MDM2 is indueed in response to DNA damage, and the resulting high levels of MDM2 protein are thought to shorten the length of the eell eyele arrest established by p53 in the radiation response. Inereased levels of MDM2 appear to ensure that the aetivity of p53 returns to its low basal levels in surviving eells. Deereased levels of MDM2 sensitize eells to radiation. Thus, MDM2 is a potential target for therapeutie intervention beeause its inhibition may radiosensitize the subset of human tumors expressing wild-type p53 sueh that radiotherapy is more efficaeious.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2006-06-28。
通讯作者:林向飞(E-mail:xiaoling79@sina.com)
更新日期/Last Update: 1900-01-01