[1]王军英,涂彧,周菊英,等.前列腺素E1注射液对急性放射性肺损伤的保护作用[J].国际放射医学核医学杂志,2007,31(2):115-117.
　WANG Jun-ying,TU Yu,ZHOU Ju-ying,et al.The protective effect of prostaglandin E1 injection on acute radiation pneumonitis[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(2):115-117.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第2期
页码:
115-117
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
The protective effect of prostaglandin E1 injection on acute radiation pneumonitis
作者:
王军英1;  涂彧1;  周菊英2;  徐晓婷2;  王利利2
1. 215123 苏州, 苏州大学放射医学与公共卫生学院放射卫生教研室;
2. 215006 苏州, 苏州大学附属第一医院肿瘤放疗科
Author(s):
WANG Jun-ying1;  TU Yu1;  ZHOU Ju-ying2;  XU Xiao-ting2;  WANG Li-li2
1. Department of Medical Radioprotection, School of Radiation Medicine and Public Health, Suzhou University, Jiangsu Suzhou 215123, China;
2. Department of Radiation Oncology, The First Affiliated to Suzhou University, Jiangsu Suzhou 215006, China
关键词:
放射性肺炎; 放射性肺纤维化; 前列腺素E类; 转化生长因子β; Sprague-Dawley大鼠
Keywords:
Radiation pneumonitis; Radiation pulmonary fibrosis; Prostaglandin E; Transforming growing factor-β; Sprague-Dawley rat
分类号:
R818.052+.5
摘要:
目的 探讨前列腺素E1注射液对放射诱发的早期肺损伤的保护作用。方法 健康雌性SD大鼠39只,随机分为3组:正常对照组、单纯照射组、照射加药组。用8MeV电子线单次20Gy照射右全肺,照射当日即给予前列腺素E1注射液(10μg·kg-1·d-1)尾静脉注射,另外两组给予等量生理盐水。照后第5、15、30日采血测定血清转化生长因子β1(TGF-β1)浓度,肺组织进行苏木素-伊红染色。结果 照射后肺组织炎症和肺水肿进行性加重;照射后5、15、30d,单纯照射组、照射加用药组血清TGF-β1水平较正常对照组进行性升高,尤以照射后15、30d升高明显(P<0.05),照射加用药组较单纯照射组的TGF-β1水平低,15、30d比较有统计学意义(P<0.05)。结论 前列腺素E1注射液能降低血清TGF-β1水平,增加肺组织对放射性损伤的耐受。
Abstract:
Objective To explore the protection of prostaglandin E1 injection with radiation-induced lung injury. Methods Thirty-nine female Sprague-Dawley rats were randomly divided into three groups:blank control group, radiation alone group and radiation plus drug group. Irridiation was given to the whole right lung by a single dose of 20Gy with 8MeV electon. Prostaglandin E1 injection 10μg·kg-1·d-1 was injected into the rats of radiation plus drug group by vena candalis per day for five days, starting on the first day. Animal of each group were sacrificed on days 5, 15, 30 respectively after irradiation. Transforming growth factor-β1 (TGF-β1) level in serum was measured and sections of right lung tissues were observed by hematoxylin and eosin staining. Results Pulmonary edema and pneumonia aggravated gradually. TGF-β1 increased significantly beginning from day 5, especially on days 15, 30 (P<0.05) in group radiation and radiation plus drug. TGF-β1 decreased on days 15, 30 (P<0.05) in group radiation plus drug. Conclusions Prostaglandin E1 injection could decrease serum TGF-β1 content. Inhabiting expression of TGF-β1 in the lung tissue might be one of the mechanisms in treatment of radiation lung injury.

参考文献/References:

1 白浪,刘建军,贺伯明.前列腺素E1对稀盐酸吸入性急性肺损伤的保护作用.复旦学报:医学版,2001,28(2):103-106.
2 刘纯杰,王德文,高亚兵,等.细胞因子及其受体在放射性肺纤维化发生中的分子病理机理研究.中华放射医学与防护杂志,2000,20(6):391-394.
3 Anscher MS, Marks LB, Shafman TD, et al. Using plasma transforming growth factor beta-1 during radiotheraphy to select patients for dose escalation. J Clin Oncol, 2001, 19(17):3758-3765.
4 林白桦,蔡晶,许昌韶.C57/BL小鼠TGF及TNF在不同时段下的变动情况与放射性肺损伤关系的研究.苏州大学学报:医学版,2004,24(3):288-290.
5 施小燕,沈惠云,洪远,等.脂微球-前列腺素E1治疗创伤后急性呼吸窘迫综合征疗效评价.中华创伤杂志,2002,18(10):589-591.
6 郭虹,朱妙珍,段建,等.前列腺素E1对输尿管梗阻大鼠肾间质纤维化及转化生长因子β1 mRNA表达的影响.中国医师杂志,2003,5(3):359-361.

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备注/Memo

备注/Memo:
收稿日期:2006-10-27。
通讯作者:涂彧(E-mail:tuyu@suda.edu.cn)
更新日期/Last Update: 1900-01-01