[1]郭阳,姜炜,张文学.立体定向放射治疗脑转移瘤疗效分析[J].国际放射医学核医学杂志,2007,31(2):122-124.
　GUO Yang,JIANG Wei,ZHANG Wen-xue.Analysis of stereotatic radiotherapy for brain metastases[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(2):122-124.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第2期
页码:
122-124
栏目:
临床放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Analysis of stereotatic radiotherapy for brain metastases
作者:
郭阳;  姜炜;  张文学
300060 天津, 天津市环湖医院放疗科
Author(s):
GUO Yang;  JIANG Wei;  ZHANG Wen-xue
Department of Radiotherapy, Tianjin Huanhu Hospital, Tianjin 300060, China
关键词:
脑转移瘤; 立体定向放射治疗; 全脑放射治疗
Keywords:
Brain metastases; Stereotatic radiotherapy; Whole brain mdiotherapy
分类号:
R730.55
摘要:
目的 分析立体定向放射疗法(SRT)治疗脑转移瘤的临床疗效。方法 回顾性分析66例脑转移瘤全脑放射治疗(WBRT)追加SRT和26例脑转移瘤单纯SRT的结果,分析两者在Karnofsky评分、颅内肿瘤复发率、一年生存率等方面的状况。结果 WBRT+SRT组在颅内肿瘤复发率(13.3%和42.2%)、中位复发时间(10.5个月和4.2个月)、中位生存期(13.0个月和6.5个月)与单纯SRT组相比有显著性差异(P<0.05),但在Karnofsky评分、治疗有效率、一年生存率、死亡率的差异均无统计学意义。结论 WBRT+SRT能明显改善患者的生存质量,降低肿瘤颅内复发率,是脑转移瘤的一种理想局部治疗手段。
Abstract:
Objective To investigate the effect of stereotatic radiotherapy (SRT) for brain metastases. Methods Retrospect compare 66 patients treated by SRT with whole brain radiotherapy (WBRT+ SRT) to 26 patients treated by SRT alone, Results The patients treated by WBRT+ SRT had significantly benefit in lesions recurrence (13,3% vs 42.2%), middle recurrence time (10.5 months vs 4.2 months) and middle survival time(13 months vs 6.5 months) over the patients treated by SRT, respectively (P<0.05), But there are no different in terms of improving of Karnofsky score, effective rate, one-year survival rate, one-year death rate between the two groups. Conclusion WBRT+ SRT play an important role in treating brain metastases, by improving patients’ life quantity and reducing recurrence.

参考文献/References:

1 Sturm V, Kober B, Hover KH, et al. Stereotactic percutaneous single dose irradiation of brain metastases with a linear accelerator. Int J Radiat Oncol Biol Phys. 1987, 13(2):279-282.
2 Huang WQ, Zeng SJ, Tang QS, et al. Statistical analysis of central nervous system tumors in China. J Neurosurg, 1982, 56(4):555-561.
3 Sneed P, Lambom K, Forstner J, et al. Radiosurgery for brain metastases:Is whole brain radiotherapy necessary?. Int J Radiat Oncol Biol Phys, 1999, 43(3):549-558.
4 Joseph J, Adler JR, Cox RS, et al. Linear accelerator-based st ereotatic radiosurgery for brain metastases:the influence of number of lesions on survival. J Clin Oncol, 1996,14(4):1085-1092.
5 Flickinger JC, Lunsford LD, Somaza S, et al. Radiosurgery:its role in brain metastasis management. Neurosurg Clin N Am, 1996, 7(3):497-504.
6 Zouhair A, Tercier PA, Fankhauser H, et al. Stereotactic radiotherapy of brain metastasis; experience in Lausanne. Schuiz Med Wochenscher, 1997, 127(40):1652-1656.
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备注/Memo

备注/Memo:
收稿日期:2006-12-05。
通讯作者:郭阳(E-mail:yanggu0622003@yahoo.com.cn)
更新日期/Last Update: 1900-01-01